Uhlalutyo emva lwezonyango Unyango yinyumoniya abosulelwe-Coronavirus Inoveli kunye Chinese Traditional Medicine Lianhua Qingwen

Yao Kai-tao 1, liu Ming-yu 1, Li Xin 2, Huang Ji-han 3, cai Hong-bin 1 *

(1.The weThoba Hospital of Wuhan, Wuhan 430081, China: 2.CR & WISCO General Hospital, Wuhan 430080, China : 3.Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China)

[Abstract] Injongo : Ukuze hlalutya ifuthe bezonyango belo amayeza emveli ase-China Lianhua Qingwen kwi unyango inoveli coronavirus-ezosulelekileyo pneumonia (NCIP) uze unike isiseko kwabakhokeli amayeza ngokusebenzisa isifundo emva kweli qela NCIP ukuqinisekisile izigulane. Indlela :Uhlalutyo kususelwa iingxelo zonyango lwaqhutywa NCIP ukuqinisekisile izigulane kwi The weThoba Hospital of Wuhan kunye Hospital CR & WISCO Jikelele kuquka iqela imithi (izigulane-21, unyango olusisiseko kunye Lianhua Qingwen Granules, 1 ipakethe / ixesha, amaxesha-3 / ngosuku) kunye iqela kolawulo (izigulane-21, unyango esisiseko). Uthelekiso phakathi kwala maqela mabini senziwa ngokwemigaqo amazinga yokuduka Iimpawu ezibalaseleyo (ifiva, ukhohlokhohlo kunye asthenia), ubude ifiva, kunye namazinga Ukunyamalala nezinye iimpawu (iintlungu kwezihlunu, expectoration, isithintelo ngeempumlo, impumlo aphilileyo, umqala owomileyo, pharyngalgia , ukuphelelwa umoya, isifuba lokubandezeleka, dyspnea, isiyezi, intloko, isicaphucaphu, ukugabha, ukungabi namdla kunye nesifo sorhudo). Umphumela: Idatha baseline baba ezifanayo phakathi kwala maqela mabini. Xa kuthelekiswa neqela kolawulo, izigulane kwiqela imithi sanegalelo eliphezulu lwezonyango, kuquka umlinganiselo yokuduka fever (85.7% vs 57.1%,  Χ 2= 4.200, P = 0.040), izinga yokuduka ukhohlokhohlo (46.7% vs 5.6%, P = 0.012), lo expectoration izinga zanyamalala (64.3% vs 9.1%, P = 0.012), izinga yokuduka ukuphelelwa ngumphefumlo (77.8% vs 0, P = 0.021), kunye nobude umkhuhlane [( 4.6 ± 3.2) d vs (6.1 ± 3.1) d, P = 0,218]. Isiphelo: Lianhua Qingwen unako kakhulu sokunceda iimpawu iyintsika e NCIP kuqinisekiswa izigulane ngokuthi ziyibuyisela umkhuhlane kunye ukukhohlela, kuncitshiswe ubude bawo, ngokunjalo nokuphucula iimpawu ngamnye. Zonke ezi ziphumo zinika ubungqina lokuqala lwezonyango ze Lianhua Qingwen Granules kwi unyango NCIP. 

[Amagama angundoqo] Lianhua Qingwen; inoveli coronavirus-abosulelwe pneumonia (NCIP); 2019-nCoV; iziguli ozinzisiweyo; Uphando lwezonyango; umkhuhlane; ukhohlokhohlo

Ubhubhane inyumoniya engaziwayo imfazwe kutshanje e Wuhan City, kwiPhondo Hubei. NgoJanuwari 12, 2020, i-World Health Organization ngokusemthethweni igama le coronavirus ezintsha okubangele inyumoniya e Wuhan njenge "2019 - nCov ' [1] . <Prevention and Control Plan of the Pneumonia Caused by the Novel Coronavirus> issued by National Health Commission of the People’s Republic of China (hereinafter referred to as NHC) named it novel coronavirus-infected pneumonia (NCIP). It is reported that the coronavirus is envelope single-strand positive-strand RNA virus[2] , 2019-nCoV amagciwane kunye ezilandelelanayo genome sele ichongiwe [3] , wabeka isiseko ebalulekileyo ukuvimbela bhubhane. Obubonakala uphawu lwezonyango ikakhulu nangecesina, asthenia, ukhohlokhohlo owomileyo, iziguli bambalwa kunye kwingxinano ngeempumlo, impumlo esihambisayo, umqala obuhlungu kunye nesifo sorhudo kunye nezinye iimpawu, dyspnea kwenzeka izigulane kakhulu kwaye ingadala ezisongela ubomi [4] . Isifo sephepha siyasulela kakhulu, abaphandi baye basebenzisa imodeli ukuvavanya "Basic Reproductive Number" yalo bhubhane ( R 0), i- R 0yi phezulu njengoko 2,682 [2] . According to the open data of NHC, until 24:00 of February 4, 24324 confirmed patients has been reported and 490 patients died across the country, it can be speculated that the mortality is 2.01%. Since the outbreak of the epidemic, number of confirmed and suspected cases climbed, the NHC has defined the disease as Class B infectious diseases regulated as the <Law of the People’s Republic of China on the prevention and treatment of infectious diseases>, prevention and control measures as Class A infectious diseases should be taken. On January 31, 2020, the disease is treated as a public health emergency of international concern by the World Health Organization, which is one of the major outbreaks caused serious damage to people’s health and public safety after severe acute respiratory ensemble Syndrome (SARS) in 2003. Currently there is no confirmed effective antiviral drugs on NCIP, clinical symptomatic support treatment based comprehensive intervention is taken[4] . Kuthethwa ukuba indima ebalulekileyo nothomalaliso of indibaniselwano amayeza yaseTshayina emveli nasentshonalanga ye-SARS kunye Class AH 1N 1umkhuhlane, ngokusekelwe iingenelo zonyango iyonke TCM kudityaniswe ekuphuculeni iimpawu yiklinikhi, amayeza emveli ase-China i kakhulu unyango NCIP .

Lianhua Qinwen njengezingxobo (Granules) yenye ezintsha lomenzi Chinese amayeza yaphuhliswa ngethuba SARS ngo-2003 kwaye samkelwa ngokusebenzisa ukubuyekezwa nozilo ichiza elitsha, kunye neziphumo kuba ezosulelayo wentsholongwane zemiphunga kwi antiviral spectrum ezibanzi, antibacterial, icesina anti-ukudumba, zikwenze ukhohlokhohlo ukusombulula phlegm, olawula amajoni omzimba ukuphazamisa [5-14] , ingakumbi uye inhibition ebalulekileyo kunye nefuthe ngokubulala for nokuphefumla syndrome SARS coronavirus kunye noMbindi Mpuma (zezi-). Eli chiza liye kuluhlu namachiza Kucetyiswa ukuba amaxesha 20 yokuphefumla esosulelayo kwisicwangciso zokuthintela izifo kunye nolawulo ekhutshwe yi-NHC kunye noLawulo State of Traditional Medicine of China. Ichiza uye waphathwa njengeyeza njengommeli Chinesed responsing ukuba iziganeko lwempilo yoluntu zemiphunga. Kwaye ichiza iye yabekwa kuluhlu iziyobisi yanconywa <Plan Prevention and Control of the pneumonia Ibangelwa i iNovel Coronavirus (Trail Edition wesine)>. Ukususela ukuqhambuka, indlela amayeza emveli ase-China nasentshonalanga uyasetyenziswa, unyango olusisiseko kunye Lianhua Qingwen Granules ngandlela elungileyo kwizigulane NCIP eqhelekileyo, idatha kwezonyango kwezi zigulane zishwankathelwe ngolu hlobo lulandelayo.

1 Uxwebhu and Indlela

1.1    Clinical Data Qokelela the clinical data of patients who were in treatment at The Ninth Hospital of Wuhan and CR&WISCO General Hospital from the date January 11, 2020 to January 30, 2020 and then confirmed as novel coronavirus-infected pneumonia (NCIP) patients by positive nucleic acid detection of sputum, throat swab and secretion of lower respiratory tracts etc.

1.2    Ukubandakanywa Iinqobo kunyangwe Common kweminyaka engama-18 kwaye iikhrayitheriya diagnostic eliqhelekileyo [4] NCIP.

1.3    Iikhrayitheriya Ukuthintelwa (1) Severe ngeliso kakhulu izigulane NCIP; (2) Acute izifo zemiphunga ayibangelwa 2019-nCoV; (3) naziphi na ezinye izifo ezingapheliyo zemiphunga, izifo zemiphunga iintsholongwane ezifana tonsils suppurative, etsolo tracheal-iphika, sinusitis, otitis media kunye nezinye izifo zemiphunga ezichaphazela lwezonyango uvavanyo trial; (4) izigulane isifuba ezifuna unyango yonke imihla, Itomography esifubeni X-reyi ngekhompyutha (CT) waqinisekisa ubukho izilonda ezinzulu pulmonary Embi, bronchiectasis kunye nezinye izifo ezisisiseko pulmonary; (5) Ehamba izifo ezisisiseko ezifana nesifo enkulu immunodeficiency ephambili, ufumene immunodeficiency syndrome, naso sokuphefumla iphecana malformation, isifo sentliziyo azalwa, dysplasia wemiphunga njalo.

1.4    ngokwamaqela Indlela Inpatients meeting the diagnostic criteria of NCIP are divided into basic treatment (recommended treatment of <Prevention and Control Plan of the Pneumonia Caused by the Novel Coronavirus (Trial)> issued by NHC) and basic treatment in combination with Lianhua Qingwen Granules (1 packet/time, 3 times/day). Among the patients of basic treatment in combination with Lianhua Qingwen Granules, patients meeting the inclusion criteria and exclusion criteria and whose body temperature was >37.2 ℃ were selected as the treatment group. Then age and body temperature were taken as covariates and the propensity score was calculated using Logistic regression model, 21 patients of basic treatment were matched at a 1:1 ratio as the control group.

1.5    Index Evaluation Thelekisa izinga yokuduka iimpawu eziphambili (ifiva, asthenia kunye ukhohlokhohlo), ixesha Ukunyamalala rate umkhuhlane kunye Ukunyamalala nezinye iimpawu umntu phakathi iqela unyango kunye neqela lolawulo le.

1.6    Statistical Indlela SAS 9.4 software yasetyenziswa analysis manani. Zonke iimvavanyo-manani zaye kabini-uhlangothi, kunye P ≤0.05 bachaza umahluko ngokwamanani. Ukubalwa data ye uhlalutyo oluneenkcukacha bachazwa ngokuthi inani lamatyala kunye ratio Ukwakhiwa, kwaye idatha yokukala kwachazwa yi ± s . Data ubuninzi zithelekiswe yi t uvavanyo, kunye neenkcukacha okuyimfihlo zaye zahlolwa yi chi-square uvavanyo okanye ngqo indlela lilonke.

2          Isiphumo

2.1    Baseline Data Qokelela ewonke 42 izigulane zesiqhelo NCIP, kuquka amadoda-16 (76.2%) kunye nabasetyhini-5 (23.8%) kwiqela imithi, kunye seminyaka yobudala 57.1 ± 14,0 iminyaka; kwaye kuquka amadoda 12 (57.1%) kunye nabasetyhini-9 (42.9%) kwiqela kolawulo, kunye seminyaka yobudala 62,4 ± 12.3 iminyaka. Idatha baseline ezahlukahlukeneyo akukho ngokwamanani phakathi kwala maqela mabini ngokwemiqathango ubudala, isini, ubushushu, uxinzelelo lwegazi, izinga intliziyo, yokuphefumla, imbali yezonyango yangaphambili, ixesha ukususela ukuqala ukuya isifo njl kunye omparability waba. Data zichazwe zibonisiwe kwitheyibhile 1.

Itheyibhile 1 Baseline data kwiqela lonyango kunye neqela lolawulo (± s, n = 21)

Group

Age

Male / zeziFundo

Body Iqondo lobushushu / ℃

ISystolic Blood Pressure / mmHg

Ukuzala Blood Pressure / mmHg

Ubushushu Rate / BPM

Rates zemigudu / min

Izigulane Previous History Medical / Subject

Ixesha ukusuka Onsert ukuya Diagnosis / d

Treatment Group

57.1 ± 14,0

16

38,56 ± 0.68

123,9 ± 12.9

75.3 ± 10.2

88,5 ± 10.8

20,0 ± 2.3

10

12.8 ± 3.8

control Group

62,4 ± 12.3

12

38,38 ± 0,63

119,3 ± 14.4

72,4 ± 9.8

88,4 ± 11.6

19.8 ± 1.3

10

12.9 ± 3.3

Statistics

-

1.298 1)

1.714 2)

0.883 1)

1.072 1)

0.924 1)

0,0271)

0.407 1)

02)

-

0.070 1)

P

0,202

0,190

0,383

0,290

0,361

0,978

0,687

1,000

0,944

Qaphela: 1mmHg ≈0.133kPa. 1) t uvavanyo; 2) chi-square uvavanyo

2.2    Ukuthelekiswa Main uphawu yokuduka Izinga (1) data Isiseko: Phakathi izigulane ezingama-21 kwiqela imithi, izigulane 21 umkhuhlane (100%), izigulane 15 waba ukhohlokhohlo (71.4%), kunye nezigulane 12 asthenia (57.1%); (2) unyango Phakathi izigulane ezingama-21 kwiqela kolawulo, izigulane 21 umkhuhlane (100%), 18 waba ukhohlokhohlo (85.7%) kunye 13 iziguli asthenia (61.9%). Kwakungekho umahluko omkhulu phakathi kwala maqela mabini. isiphumo: when compared with the control group, fever disappeared in 18 patients in the treatment group(85.7%), which is significantly better than the 57.1% in control group (X 2=4.200, P =0.040); and cough symptom disappeared in 7 patient(46.7%), which is significantly better than the 5.6% in control group (P =0.012); The differences of the two index between the two groups have statistically significant(P <0.05). There was no significant difference in the disappearance rate of asthenia symptoms between the two groups (P =0.688). Detailed data are shown in table 2.

Table 2 Main amazinga uphawu Ukunyamalala iqela unyango kunye neqela lolawulo

uphawu

Treatment Group

control Group

Χ 2

P

n

Inombolo wanyamalala

wanyamalala

umyinge%

n

Inombolo wanyamalala

wanyamalala

umyinge%

fever1)

21

18

85.7

21

12

57.1

4,200

0,040

ukhohlokhohlo2)

15

7

46.7

18

1

5.6

-

0,012

Asthenia 2)

12

5

41.7

13

4

30.8

-

0,688

Qaphela: 1) chi-square uvavanyo; 2) ngqo indlela okuba

2.3    Ukuthelekiswa ithuba fever Bekukho izigulane ezingama-21 kwiqela imithi, kunye nexesha ubude ifiva iintsuku (4.6 ± 3.2). Kukho izigulane 21 aba kwiqela kolawulo, ixesha ubude ifiva iintsuku (6.1 ± 3.1), Akukho mahluko Akukho ngokwamanani phakathi kwamaqela ( P = 0.218).

2.4    Ukuthelekiswa izinga yokuduka ezinye iimpawu Le expectoration nephika iimpawu umoya kwiqela unyango aba 64.3% kunye 77,8%, ngokulandelelana. Xa kuthelekiswa neqela kolawulo, umahluko baba ngokwamanani ( P <0.05); Kwakungekho mahluko kakhulu kwezinga yokuduka ezinye iimpawu phakathi kwala maqela mabini. Jonga Uluhlu 3 data eneenkcukacha.

Uluhlu 3 Ezinye amazinga uphawu Ukunyamalala iqela unyango kunye controlgroup

Object

group imithi

iqela lolawulo

P

n

inani Ukunyamalala

rates zanyamalala%

n

inani Ukunyamalala

rates zanyamalala%

ubuhlungu imisipha

6

4

66,7

7

2

28.6

0,286

expectoration

14

9

64.3

11

1

9.1

0,012

rhinobyon

3

1

33.3

0

0

0

-

impumlo esebenzayo

3

1

33.3

0

0

0

-

pharyngalgia

3

1

33.3

3

1

33.3

1,000

anhelation

9

7

77,8

5

0

0

0,021

esifubeni usizi

7

5

71,4

9

2

22.2

0,126

dyspnea

2

1

50.0

2

1

50.0

1,000

intloko ebuhlungu

4

2

50.0

1

0

0

1,000

isizothe-zothe

4

2

50.0

3

2

66,7

1,000

ukumgabhisa

4

3

75,0

0

0

0

-

iphango

11

4

36.4

12

2

16.7

0,371

isisu

5

3

60,0

3

2

66,7

1,000

Qaphela: I-data zilungiswa usebenzisa ngqo indlela lilonke.

3 Ingxoxo

Ngokutsho iingxelo, iimpawu eziphambili kwezonyango NCIP zezi nangecesina, iintlungu kwezihlunu, asthenia, expectoration, ukuphelelwa umoya, intloko ebuhlungu, kunye pharyngalgia, ukubaleka impumlo, urhudo, isicaphucaphu nokugabha, njl [2,15] . According to the<Diagnosis and treatment plan for pneumonia caused by novel coronavirus > (Trial Fifth Edition)[4] ezikhutshwe yi-Commission yezeMpilo yeSizwe, i ngakumbi iimpawu sifo nangecesina, asthenia, kunye ukhohlokhohlo owomileyo, izigulane zimbalwa uneempawu ezifana isithintelo ngeempumlo, ukubaleka impumlo, pharyngalgia, urhudo. Academician Zhong Nanshan ye-Chinese Academy of Engineering wachaza kudliwano-ndlebe kuphela kunye IXINHUA News Agency ukuba fever nangoku inokuphumela ubalulekileyo kwaye ngokuqhelekileyo phakathi izigulane NCIP-kwafunyaniswa [16] , ngoko esi sifundo ekhetha baqinisekisa izigulane nangecesina njengoko main kubonakaliswa clinical ukuvavanya ukusebenza amayeza emveli ase-China. Ngelo xesha, xa ngokujonga ukunqongophala amakhambi antiviral olusebenzayo ezichongwe yi NCIP, ukuphucula iimpawu zonyango ezinxulumene kwizifo ezifana fever, ukukhohlela, kunye asthenia sibaluleke lwezonyango ibalulekile kothula nobungozi besi sifo yaye kuphungulwe ixesha sifo .

Le COVID-2019 bobabo kudidi "Epidemic Disease" Chinese Medicine. Eyona nto ephambili ebangela isifo uhlaselwa ububi nendyikitya yokufa, uze emva koko bangena sangaphakathi akhokelela impendulo yokukrala ke Pathogenesis ebalulekileyo. Le nto iyahambelana nomgaqo iimpawu kwezonyango fever njengoko imbonakaliso eyintloko NCIP. Formula Lianhua Qingwen kuba i Chinese Patent Medicine, olusekelwe phezu kwithiyori isifo ngummeli wowona amayeza emveli ase-China ukutyhila umthetho ukosuleleka zizifo ezosulelayo isixokelelwano sokuphefumla ezibangelwa ziintsholongwane kwaye nendlela "ukugawulwa kude isifo kunye detoxication, nazisasaza wemiphunga ukhulula nobushushu ". Le fomula isekwe kwi usebenzise Shigan decoction kwi imbali Zhang Zhongjing ngomhla Febrile Izifo ye-Han Dynasty kunye Yinqiao powder in imbali Wu Jutong ku bhubhane febrile izifo Qing Dynasty, nokuzoba kumava Wu Youke xa ekunyangeni izifo bhubhane kunye rhubarb kwi ama on Epidemic Febrile izifo ze kaMing, kuhlanganiswa kunye Rhodiola rosea ukucima kwemiphunga, lisuse stasis igazi nokulawula umsebenzi omzimba. Ifomula yayiyiminyaka 2,000 yamava kusetyenziso amayeza emveli ase-China ekuthintelweni kunye nokunyangwa kwezifo ezifana. Kuyinto ngokwezonyango esebenzayo isixokelelwano sokuphefumla izifo ezosulelayo ngumkhuhlane, kuthibaza, ukukhohlela, ukuqaqamba kwezihlunu njalo njalo. Izifundo pharmacodynamic Previous baye baqinisekisa ukuba iyeza Chinese Lianhua Qingwen abangaphangeliyo umsebenzi ntsholongwane SARS-selwe kakhulu kwinkcubeko vitro [17] , kwaye ngexesha elinye kunempembelelo ethile inhibitory kwi umsebenzi zezi--selwe, nto leyo ikuluhlu "kuMbindi Mpuma kungaPhefumli syndrome Case diagnosis and Treatment Scheme (2015 version) [18] ", multi-sigaba anti-umkhuhlane intsholongwane Iklasi A H1N1 kunye H3N2 [19-20] , zinqanda ngokubalulekileyo H7N9 umkhuhlane weentaka virus [21] , kananjalo babe antibacterial, anti-ukudumba, antipyretic, khohlo, phlegm, kwaye ulawulo okukwazi kunye nezinye [5-14] . Iziphumo zophando pharmacodynamic ngentla ziqinisekisa ukuba Chinese amayeza emveli Lianhua Qingbing neneempawu 'lulonke ummiselo kwaye multi-ekujoliswe unyango ", yaye ingqina scientificity kwethiyori yayo kunye nefomula.

Olu phando yayiquka 42 kuqinisekiswa izigulane NCIP iimpawu nangecesina, ephelekwa imigangatho eyahlukeneyo ukukhohlela, asthenia, expectoration, iintlungu kwezihlunu, anhelation, pharyngalgia, isicaphucaphu, ukugabha, ukungabi namdla, kunye norhudo. Iziphumo zabonisa ukuba unyango eqhelekileyo edityaniswe Lianhua Qingwen Granules inokulunciphisa kakhulu iimpawu zonyango ezifana fever, ukukhohlela, expectoration kunye anhelation, nangona kwakungekho mahluko manani ngexesha yokuduka ifiva, yimihla 1.5 emfutshane iqela lokulawula. Kwakhona kuye kwaboniswa ukuba iingenelo zonyango ekuphuculeni iimpawu nomkhuhlane. Kwangaxeshanye, ichiza nayo ibonisa iziphumo ezincumisayo ekuphuculeni iimpawu asthenia, iintlungu kwezihlunu, rhinobyon kunye intloko ebuhlungu. Compound Chinese Medicine babe ixabiso isicelo lwezonyango ezibalulekileyo zokuphucula iimpawu, ukhulula isifo kwaye kuphungulwe ixesha sifo kungekho amachiza asebenza antiviral esi sifo ngokudlala iimpawu iingenelo "ummiselo ngokubanzi, unyango multi-ekujoliswe".

Iziphumo zokuqala zolu phononongo ziyangqinelana zophononongo ingxelo ngaphambili amayeza emveli ase-China Lianhua Qingwen, ezifana kwetyala 2009 random, kabini-iimfama, multi-iziko kwezonyango Lianhua Qingwen philisi ngenxa yonyango Class AH 1N 1umkhuhlane [22] , ebonisa ukuba ichiza kufuneka akukho mahluko kunye Oseltamivir phosphate ukuba ekunciphiseni ixesha nucleic acid egazini ukuyitshintsha elibi kunye nexesha zonke iimpawu yomkhuhlane, uze ube bhetele ngaphezu oseltamivir phosphate kwi isiqabu of ukukhohlela, bomzimba kwezihlunu, asthenia kunye nezinye iimpawu . Omnye lunomkhethe, olawulwa ukufunda kwezonyango Lianhua Qingwen philisi ngenxa yonyango Class AH 1N 1umkhuhlane bafumanisa ukuba ichiza engqinelana ngokusisiseko iziphumo ngentla [23] . Ukongeza, ucazululo kususelwa Lianhua Qingwen amayeza esibhedlele elityunjelwe influenza A H1N1 flu-eBeijing Ditan Hospital [24] uqinisekise isicelo kwexesha antipyretic Lianhua Qingwen philisi kaThixo, wentsholongwane egazini nucleic acid ukuyitshintsha ngexesha elibi into efanayo oseltamivir. Iziphumo zophando ngasentla abubungqina lwezonyango ezifunyenwe ngethuba 2009 H1N1 umkhuhlane loqhambuko, ebonisa ukuba iyeza Chinese Lianhua Qingwen oye wadlala indima ebalulekileyo ekuthinteleni nokulawula imicimbi yezempilo yoluntu zemiphunga esibangelwa yintsholongwane. Kudityaniswe iziphumo zolu phononongo, eli chiza kucetyiswa ukuba elinexabiso isicelo lwezonyango ezithile unyango NCIP.

Makucaciswe ukuba olu phando isekelwe khrayitheriya ngokubanzi diagnostic ukuba <diagnosis kunye nesicwangciso unyango pneumonia okubangelwa coronavirus inoveli> ekhutshwe yi-NHC. Izigulane zaqokelelwa kwaye ifakiwe kwizifundo zonyango emva. Traditional Chinese Medicine dialectics okwangoku lwenziwa. Kunye nobungakanani isampuli incinane, ukunqongophala viral yokutshintsha nucleic zibe ezingakhiyo serological yoviwo data inkxaso, i ukuswela yophando. Le ubungakanani Isampulu iza kwandiswa kwixesha elizayo, yaye isifundo kutshata, lulingo lwezonyango ziya kuqhutywa ukuvavanya nangakumbi ukusebenza lwezonyango zezonyango yaseTshayina Lianhua Qingwen ekunyangeni NCIP.

Reference

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[24] Wang Yuguang, Du Hongbo, Mao Yu, et al. Uhlalutyo lweempawu kwezonyango amatyala 326 ka-H1N1 influenza wobulali [J]. Global Chinese Medicine, 2011, 4 (1): 31-34.

 

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