Iziphumo Chinese Traditional Medicine Lianhuaqingwen kwi Izigulane 51 ne pneumonia Inoveli Coronavirus-aboSulelwe: Multicenter umva Research

Cheng Dezhong 1 , Wang Wenju 2 * , Li Yi 1, Wu Xiaodong 2 , Zhou Biao 3 # , Sing Qiyong 1 #

1Puren Hospital Affiliated ukuya Wuhan University of Science and Technology, Wuhan, 430081, PRC; 2CR & WISCO General Hospital, Wuhan, 430080, PRC; 3Wuhan weThoba Hospital, Wuhan, 430081, PRC

* Linikelwe ngokulinganayo kulo msebenzi kunye umbhali wokuqala

# Oluhambelana ababhali: Rong Biao, Email: ykt2020@126.com; ICULO Qiyong, Email: 389755852@qq.com

Abstract Injongo: kukuhlalutya ukusebenza lwezonyango isicelo odityanisiweyo we Lianhuaqingwen Granules (LH-C) kwi coronavirus inyumoniya inoveli (NCP). Indlela: data Clinical yaqokelelwa izigulana eqhelekileyo NCP kwi Puren Hospital Affiliated ukuya Wuhan University of Science and Technology, CR & Hospital WISCO Jikelele, kunye Wuhan Hospital weThoba ngoJanuwari 2020 ukulungiselela isifundo emva clinical. Phakathi izigulane bethe bayifezekisa le miqathango ubandakanyo kunye nokukhutshelwa ngaphandle, 60 amatyala abafumana LH-C edityaniswe kwanonyango yesiqhelo zaye zabandakanywa kwiqela imithi, 60 amatyala ekufumaneni unyango eqhelekileyo zaye zabandakanywa kuphela kwiqela kolawulo, kunye olungaka lomntu 1: 1. Uthelekiso senziwe phakathi kwala maqela mabini ngokubhekiselele kwiqondo yokuduka, ubude, kunye nezinga olusebenzayo iimpawu ukhadinali (ifiva, ukutyhafa, kunye ukhohlokhohlo), izinga Ukunyamalala ezinye iimpawu, umfanekiso pulmonary (CT) japan uphuculo rate, njl Iziphumo: Khange kubekho umahluko omkhulu kwizinto baseline phakathi kwala maqela mabini. Izigulane kwiqela ngalinye bafumana unyango aqhelekileyo kunye okanye ngaphandle LH-C iintsuku ezisi-7, izinga yokuduka khadinali uphawu kwiqela imithi yaba 83.7%, 61,3%, kunye 62.2%, ngokulandelelana, ngokuchaseneyo 61,0%, 34.3%, kunye 35,9% kwiqela kolawulo ( P <0.05). Ixesha eliqhelekileyo khadinali uphawu kwiqela imithi iintsuku (2.9 ± 1.67), kwiintsuku (3.5 ± 1.50), kunye neentsuku (3.9 ± 1.98), ngokulandelelanayo, ngokuchaseneyo kwiintsuku (3.9 ± 1.29), (4.8 ± 1.53) iintsuku, kunye neentsuku (5.2 ± 1.76) kwiqela ulawulo ( P <0.05). Inkululeko Iimpawu ezibalaseleyo yenzekile kwizigulane mane anesine neqela lonyango (86.3%) kunye mathathu anesihlanu izigulane kweqela ulawulo (68.6%), ebonisa umahluko omkhulu phakathi kwala maqela mabini ( P = 0.033). Izinga Ukunyamalala expectoration, ukuphelelwa umoya, isifuba lokubandezeleka, ilahleko wokutya, kwaye uphawu rale ofumileyo yaba 55,0%, 61,5%, 54,6%, 34,8%, no-45.5%, ngokulandelelana, kwiqela imithi ngokuchaseneyo kwi 15.8%, 14.3 %, 15.8%, 7.7%, kunye 13.0% kwiqela kolawulo (P <0.05). Izigulane ezine kwiqela unyango (7.8%) kunye nezigulane elinanye kwiqela kolawulo (21.6%) aqhubela phambili i-NCP kakhulu ngexesha unyango ( P <0.05). Izigulane ezimashumi mabini anesibhozo kwiqela unyango (54.9%) kunye nezigulane ezingamashumi amabini anesithathu kwiqela le kulawulo (45.1%), waba pulmonary CT nombono ukuphuculwa ( P > 0.05). Isiphelo: LH-C edityaniswe kwanonyango yesiqhelo akwazi ukuphucula kakhulu iimpawu kwezonyango izigulane NCP kuqukwa umkhuhlane, ubuthathaka, khohlo, expectoration, ukuphelelwa umoya, esifubeni lokubandezeleka, kunye nelahleko wokutya, ukunciphisa rale yemiphunga efumileyo, ukuphucula izinga ngokukuko khadinali uphawu , nokunciphisa ukuqhubela phambili. Ezi ziphumo wacebisa LH-C inokuba ngempumelelo izigulane NCP eqhelekileyo.

Amagama angundoqo COVID-19; Inyumoniya coronavirus inoveli; Lianhuaqingwen; Uphando lwezonyango; Uhlalutyo ukusebenza; Multicenter uphando emva

 

Inoveli coronavirus pneumonia (NCP) uye waba ngomnye ezinjengoobhubhane emikhulu impilo engozini yoluntu kunye nokhuseleko loluntu. Uphando lubonisa ukuba [1] intsholongwane yalo bhubhane bobabo kumaqela intsholongwane Okunzima ezihlasela zosulele ngokuphefumla syndrome (SARS-selwe) kunye noMbindi Mpuma kungaPhefumli syndrome (zezi--selwe). Ngokutsho emthini phylogenetic of coronavirus, kuba ngokusondeleyo obuphathelele Chinese intloko ifildi bat uhlobo SL ZC45 (Bat-SL-CoVZC45), homology yalo ngaphezu kwama-85%, kwaye yonyulwa SARS-selwe-2. NgoFebruwari 11, 2020, i-World Health Organization ngokusemthethweni igama esi sifo ebangelwe coronavirus omtsha (SARS-selwe-2) njenge "2019 Coronavirus Disease (COVID-19)" [2] . Ngokutsho uhlalutyo ityala phambi kwexesha, SARS-selwe-2 mncinci kakhulu kwe SARS-selwe kunye zezi--selwe, Noko ke, njengoko inani lamatyala rhoqo, ngakumbi nobungqina ngakumbi yokosulela nabanye ibonisa ukuba siyasulela ngaphezu SARS- selwe and MERS- selwe [3-7] . Abanye abaphandi baye benza imodeli ukuvavanya i "Basic Reproductive Number" (R 0) imeko bhubhane kwaye wafumanisa ukuba yafika 2,68 [8] , oko kukuthi, umntu omnye osulele abantu-2 ukuya kwemi-3 avareji. Ngokutsho kwe data kupapashwa kuqala yiKomishoni yezeMpilo yeSizwe ye-Peoples Republic of China [9] , njengoko ka 24:00 ngoFebruwari 17, bekukho 72,436 ukuqinisekisile amacala, ukufa 1,868, kwaye 11,741 amatyala kakhulu. Zizonke 560.901 abafowunelwa close zaye zondelwe. Kukho abantu 141.552 kugadwe. Oku kunokubonwa ukuba SARS-selwe-2 siyasulela kakhulu, enoluhlu olubanzi lweempembelelo. Oku kuphakamisa nokuthintela kakhulu kwaye umngeni ulawulo ukuya kwilizwe lethu yaye ihlabathi liphela, kwakunye nokwanda ntsholongwane iye nyonke kwingxakeko lwempilo yoluntu inkxalabo ngamazwe [10] .

Ubhubhane liphuhlise ngokukhawuleza, kwaye inani iziganeko ezingalindelekanga kuya kubangela nemiphumela emibi kakhulu. Uhlolisiso amatyala 72.314 kumaphondo 31 nezixeko kwilizwe lonke bafumanisa ukuba phakathi amatyala 44.672 yaqinisekisa kwakukho 13.8% Kwiingozi ezimasikizi, 4.7% iimeko ezinzima, kunye nokusweleka 1023, kwaye izinga lokusweleka crude (Ltd) nama-2.3% [11 ] . Esinye isifundo kwe-138 izigulane baqinisekisa lufumanise ukuba-26% ezigulane ezifunekayo ukwamkelwa kwicandelo labagula kakhulu kwaye izinga lokusweleka izigulane baqinisekisa yafikelela 4.3% [12] . Kukho kwakhona isifundo ngamatyala 1099 ukusuka kwizibhedlele 552 e-China ingxelo ukuba umyinge kuqinisekiswa-isigulane kwiimeko kakhulu ekuguquleni ifikelela 15.7%, kwaye izinga lokusweleka lwezonyango yi 1.4% [13] . Njengoko Zhong Nanshan, i academician ye-Chinese Academy of Engineering, kuchaziwe qhinga imithi ukuze semiphunga coronavirus inoveli ukuba lo bhubhane kuba nzima ngaphezu SARS in kuthintelo kunye nolawulo, ingakumbi kwiimeko kakhulu kuya kubangela nokulimala ukuba izigulane, wabangela ngakumbi nzima ukunyanga isigulana ngaphezu unyango SARS [14] . Nangona kunjalo, akukho nangoku akukho kuqinisekiswa unyango olusebenzayo antiviral for COVID-19, kunye nonyango kwangumqondiso kwaye inkxaso yeyona ndlela iphambili lwezonyango [15] . Ngoko ke, ukubhaqwa, uphethwe ngexesha yiklinikhi, amanyathelo ngokukhawuleza onesifo [16] , kunye nokubambelela Chinese ibandakanyiwe kwaye unyango amayeza Western [17] ziye amanyathelo unyango clinical ebalulekileyo yokulwa bhubhane, leyo zokubaluleka enkulu ukuvimbela bhubhane kunye nolawulo.

Njengoko ingxelo, ummandla ubhubhane e Hubei sele ngokubanzi kumiselwa indlela abasebenza lokhuseleko kunye nonyango ngokuhlanganisa Chinese amayeza emveli kunye amayeza asentshona, kwaye ngokubanzi kukhuthazwa ukusetyenziswa kwayo [18] . Ngokutsho manani, izinga inxaxheba amayeza emveli ase-China kwindawo bhubhane indawo Hubei yi-75%, kwaye non Hubei-bhubhane indawo yi kwama-90%. Olunye uhlolisiso lubonisa ukuba ngaphezu kwama-80% ezigulane kunye COVID-19 isifo kakhulu khetha ngokubonakalayo unyango amayeza yaseTshayina nasentshonalanga zemveli oludibeneyo, kwaye ngaphezu kwama-90% ezigulane ukukhanya ithemba lokuba amayeza Tshayina angenelele. Uninzi lwabantu kungaphumi ulindele ungenelelo yokuqala amayeza emveli ase-China, kunye nezigulane bekhululwe esibhedlele wonelisekile nzima unyango amayeza Chinese [19] . Njengoko kaFebruwari 17, 2020, 85.2% kwezi amacala ukuqinisekisile ibandakanya amayeza yaseTshayina kwi unyango [20] . Ngoko ke, ekubeni kokuqhambuka bhubhane, umbhali uye lithathe unyango kunye indibanisela amayeza emveli ase-China kunye namayeza yasentshona. Indibaniso Lianhuaqingwen Granules (LH-C) kunyango oluqhelekileyo lwe NCP kuqinisekiswa ukusebenza unyango entle isigulane. Idatha kwezonyango amatyala athi emva zihlalutywe kule ngxelo ukuze ukunika isiseko uphando Chinese lwezonyango oludibeneyo kwaye unyango amayeza yasentshona.

1        Izinto kunye neendlela

1.1    Izifundo

data Clinical yaqokelelwa izigulana eqhelekileyo NCP kwi Puren Hospital Affiliated ukuya Wuhan University of Science and Technology, CR & Hospital WISCO Jikelele, kunye Wuhan Hospital weThoba ukususela ngoJanuwari 1 January 30, 2020, abo bazimisele ukuba NCP eziqondile nucleic acid iimvavanyo zesikhohlela, ilaphu umqala, kunye netuwa asezantsi phecana sokuphefumla.

1.2    Iikhrayitheriya Ukubandakanywa

Izigulane phakathi kweminyaka eli-18 kunye nama-70 lowo wadibana NCP jikelele-injongo iindlela zokuxilonga ukuba "diagnosis kunye nonyango ezintsha coronavirus semiphunga (Trial Version 5) ' [15] yaye esibhedlele iintsuku ezingaphezu kwama-6.

1.3    Iikhrayitheriya okungayi

① izigulane NCP kakhulu nezibaluleke kakhulu; ② naziphi na ezinye izifo ezingapheliyo zemiphunga, izifo zemiphunga iintsholongwane ezifana ubovu tonsils, etsolo tracheobronchitis, sinusitis, otitis amajelo eendaba, kunye nezinye izifo zemiphunga echaphazela uvavanyo; ③ izifo kakhulu interpulmonary, okanye izifo ezisisiseko ezifana izilonda ezisemgangathweni, bronchiectasis, isifo immunodeficiency zaseprayimari, malformations iziphene nokuphefumla, isifo sentliziyo azalwa, ukungaqheleki zophuhliso umphunga; ④ ephelekwa izifo kakhulu kwesibindi (amanqanaba aspartate aminotransferase AST, alanine aminotransferase ALT lugqithe ngaphaya umda aphezulu amaxabiso eqhelekileyo izihlandlo ezi-5), okanye izigulana kunye insufficiency sezintso kakhulu okanye kokwenziswa oluqhubekayo therapy replacement kwezintso, wehemodialysis, dialysis peritoneal; ⑤ kukho nangezilonda yingozi, izifo igazi, cachexia, imisebenzi ube metastases ezininzi kwaye ayikwazi resected ukopha, ukungondleki kakhulu,-HIV, njl, okanye ubunzima kwizifo kakhulu-luvo nasengqondweni.

1.4    ngokwamaqela ndlela:

Amashumi amahlanu ananye (51) izigulane iikhrayitheriya of Faka kunye Ukuthintelwa ziphathwa Lianhuaqingwen Granules (LH-C) ukulungiselela ≥ 5 iintsuku yaqokelelwa njengeqela imithi. Emva koko, usebenzisa ubudala, ubushushu, yaye ke kwezifo njengoko covariates. Imifuziselo nokushiywa yobuchule zasetyenziswa ukubala amanqaku wayevuma. 51 izigulane zifumana unyango eqhelekileyo zaye ifaniswe 1: ratio 1 njengeqela yolawulo.

1.5    indlela zonyango

Iqela Control: unyango zenkxaso ngesondlo elula, unyango kwangumqondiso, unyango antiviral kunye antibacterial. Iqela Unyango: Based on iqela kolawulo, edibana ngayo LH-C (6g / ibhegi, Shijiazhuang YiLing Pharmaceutical Co., Ltd., National Medicine Code Z20100040), 1 ibhegi sihlandlo ngasinye, ka-3 ngosuku. Qokelela ulwazi lwezonyango lwezigulane baphathwa iintsuku ezisi-7.

1.6    Iimpawu Ukuqaphela

Thelekisa amaqela amabini ngokwemiqathango kwezinga yokuduka iimpawu ukhadinali (ifiva, ukutyhafa, kunye ukhohlokhohlo), imihla yokuduka, kwakunye nezinga Ukunyamalala ezinye iimpawu, izinga olusebenzayo iimpawu ukhadinali, umfanekiso pulmonary (CT) japan uphuculo rate, kwaye izinga soguqulo zonyango kakhulu.

1.7    Indlela Evaluation

izinga Ukunyamalala iimpawu ezibalaseleyo: Inani iimpawu ityala wanyamalala emva unyango / inani lamatyala. izinga ②Effective Iimpawu eziphambili: ngokuba iimpawu eziphambili (ifiva, ukudinwa, ukhohlokhohlo), 0 amanqaku for "hayi" kwaye 1 indawo for "ewe", (pre-unyango - emva konyango) nomonde nomonde kwamanqaku / pre-unyango score uphawu lizinga score, xa uphawu score rate kuncipha> 30%, oko bagwetywa ukuba ngempumelelo, kwaye xa ≤ 30%, oko bagwetywa ukuba angasebenzi. Inani lamatyala bagwetywa ukuba / inani olusebenzayo lilonke lamatyala. ukwenza umfanekiso ③pulmonary (CT) japan rate ngcono: Inani lamatyala ebonisa ukuphucuka umfanekiso lung (CT) emva unyango / inani lamatyala; ④the izinga ukuguqulwa zonyango kakhulu: jonga ityala criteria zokuxilonga kakhulu kwi "diagnosis kunye nonyango ezintsha coronavirus semiphunga (Trial Version 5) '[15] ukuba inkcazo amatyala Sever. Izinga ukuguqulwa zekliniki Sever linani lamatyala aguqulwa ukusuka eqhelekileyo esinzima / inani elipheleleyo lamatyala.

1.8    Iindlela Statistical

Uhlalutyo lwamanani lwenziwa kusetyenziswa SAS 9.4 software. Zonke iimvavanyo-manani zenziwa kusetyenziswa iimvavanyo-kabini ezimbini. uhlalutyo oluneenkcukacha lwe data count ichazwa inani lamatyala kunye ratio nokwakheka. idatha yokukala yamanani bachazwa by ± ecaleni. Yomfundi t-vavanyo yasetyenziswa ukuthelekisa idata yomlinganiselo phakathi kwamaqela, yaye uvavanyo Chi-isikwere okanye ngqo indlela amathuba yasetyenziswa ekuhlalutyeni data ukubala. Ubude ifiva yacazululwa yi uhlalutyo lokusinda. Umahluko kwaba ngokwamanani xa P≤0.05.

 

iziphumo

2.1  Inkcazelo ngokuthe gabalala

Zingama-102 izigulane kuqinisekiswa obuqhelekileyo wadibana iimfuno angeniswe (kubandakanywa amatyala 32 Puren Hospital lwembali Wuhan University of Science and Technology, iimeko 18 CR & WISCO Hospital General ,, kunye namatyala 52 Wuhan weThoba Hospital). Kwiqela imithi izigulane 51, kwakukho amadoda 26 (51.0%), iimazi 25 (49.0%), ubudala avareji, komndilili weqondo lobushushu (55.5 ± 12.3) ubudala emzimbeni (38.44 ± 0.63) ℃ kunye; iSystolic uxinzelelo lwegazi (122.6 ± 11.9) mmHg, ukuzala uxinzelelo lwegazi (75.0 ± 9.2) mmHg; izinga intliziyo avareji (89.0 ± 11.6) ibetha / ngomzuzu, avareji repiration (19.8 ± 2.4) Ukuphefumla / minute. Kuba imbali yezonyango, iimeko-15 kunye lwegazi lwangaphambili (29.4%), iimeko ezi-5 kunye nesifo sentliziyo (9.8%), amatyala 4 abanesifo seswekile (7.8%), iimeko ezi-3 kwaye iqhosha ebuchotsheni (5.9%). Luhlolo elebhu: ezimhlophe yehle legazi kwiimeko-13 (25.5%), ukuncipha lymphocyte kwiimeko-20 (39.2%), ukwanda protein C-yovukelo kwiimeko-40 (78.4%), ukunyuka kweqondo neentlenge erythrocyte kwiimeko-20 (39.2%) , yaye anda procalcitonin kwiimeko-16 (31.4%). ;

Kukho iimeko 51 kwiqela kolawulo, kuquka amadoda 27 (52.9%), iimazi-24 (47.1%) nabo, kunye seminyaka yobudala (55.8 ± 11.6) kunyaka zithengiswe, komndilili weqondo lobushushu emzimbeni (38.33 ± 0.64) ° C, iSystolic uxinzelelo lwegazi (127.0 ± 16.3) mmHg,; ukuzala uxinzelelo lwegazi. (74.8 ± 10.3) mmHg; izinga intliziyo avareji (88.7 ± 13.4) ibetha / min, uphefumlele athetha (20.0 ± 2.8) Ukuphefumla / min. Kuba imbali yezonyango, amatyala 17 lwegazi lwangaphambili (33.3%), iimeko ezi-2 kunye nesifo sentliziyo (3.9%), amatyala-4 kunye nembali Diabetes (7.8%), kunye iimeko ezi-6 kunye iqhosha ebuchotsheni (11.8%). Luhlolo elebhu: sehla iiseli ezimhlophe zegazi kwiimeko-16 (31.4%), ukuncipha lymphocyte kwiimeko-24 (47.1%), ndakumandisa iiproteins C-yovukelo kwiimeko 42 (82.4%), ukunyuka kweqondo neentlenge erythrocyte kwiimeko-24 (47.1% ), ndanda procalcitonin iimeko-17 (33.3%) kuyo.

Kwakukho umahluko Akukho ngokwamanani phakathi kwala maqela mabini ubudala, isini, kunye data olusisiseko efana ubushushu bomzimba, uxinzelelo lwegazi, izinga intliziyo, ukuphefumla, imbali yezonyango yangaphambili, kunye neziphumo zovavanyo laboratory (P> 0.05), ngoko ukuba la maqela mabini efana. Bona Itheyibhile 1.

Itheyibhile 1 general information comparison between the two groups

into

Iqela lonyango (N = 51)

Iqela Control (N = 51)

Statistics

t / c 2

ixabiso P-

Age (unyaka omnye epheleleyo ebomini, ± s)

55.5 ± 12.3

55,8 ± 11.6

-0,127

0,550

Male (mzekelo,%)

26 (51.0%)

27 (52.9%)

0,039

0,843

lobushushu emzimbeni (℃, ± s)

38,44 ± 0,63

38,33 ± 0,64

0,848

0,398

uxinzelelo lwegazi iSystolic (mmHg, ± s)

122,6 ± 11.9

127,0 ± 16.3

-1,561

0,122

uxinzelelo lwegazi ukuzala (mmHg, ± s)

75,0 ± 9.2

74,8 ± 10.3

0,101

0,920

Izinga Heart (ibetha / min, ± s)

89,0 ± 11.6

88,7 ± 13.4

0,126

0,900

uphefumlele (phefumla / min, ± s)

19.8 ± 2.4

20,0 ± 2.8

-0,527

0,599

imbali yezonyango (mzekelo,%)

27 (52.9%)

26 (51.0%)

0,039

0,843

--Hypertension

15 (29.4%)

17 (33.3%)

0,182

0,670

isifo sentliziyo --Coronary

5 (9.8%)

2 (3.9%)

-

0,436

--Iswekile yemellitus

4 (7.8%)

4 (7.8%)

-

1,000

iqhosha --Cerebral

3 (5.9%)

6 (11.8%)

-

0,487

Leukocyte ukungaqheleki (↓) (mzekelo,%)

13 (25.5%)

16 (31.4%)

0,434

0,510

Lymphocyte ukungaqheleki (↓) (mzekelo,%)

20 (39.2%)

24 (47.1%)

0,639

0,424

ukungaqheleki protein C-izidubuli (↑) (mzekelo,%)

40 (78.4%)

42 (82.4%)

0,249

0,618

ESR (↑) (例,%)

20 (39.2%)

24 (47.1%)

0,639

0,424

Procalcitonin (↑) (mzekelo,%)

16 (31.4%)

17 (33.3%)

0,045

0,832

Qaphela: Ukuze into eyindoda imbali, yempilo, japan iimviwo Ilabhoratri data count, yaye uvavanyo Chi-square wasetyenziswa uhlalutyo, ngoxa kusekelwe idatha yokulinganisa, kunye Student i-t-vavanyo yasetyenziswa uhlalutyo. 1mmhg ≈0.133kpa.

2.2  Ukuthelekiswa izinga yokuduka khadinali uphawu phakathi kwamaqela amabini

ulwazi olusisiseko: Ngokuba ityala 51 kwiqela imithi, 43 ifiva (84.3%), 31 lidiniwe (60.8%) kunye 37 ukhohlokhohlo (72.6%); ngokuba ityala 51 kwiqela wolawulo, 41 ifiva (80.4%), 35 lidiniwe (68.6%) kunye 39 ukhohlokhohlo (76.5%). Emva kweentsuku ezisi-7 unyango, xa kuthelekiswa neqela kolawulo, iimpawu qete kwiqela lonyango aba amatyala 36 (83.7%), ngcono kakhulu kunokuba iimeko-25 kwiqela kolawulo (61.0%) (x 2= 5.461, p = 0,019 ), iimeko-19 iimpawu ukudinwa unyamalale (61.3%), ngcono kakhulu kunokuba amatyala 12 kwiqela kolawulo (34.3%) (x 2= 4.813, p = 0.028), 23 amatyala iimpawu ukhohlokhohlo unyamalale (62.2%), kakhulu ngcono iziganeko 14 kwiqela le kulawulo (35.9%) (x 2= 5.243, p = 0.022). Bona Itheyibhile 2.

Table 2 Ukuthelekiswa izinga yokuduka khadinali uphawu kumaqela amabini Izigulane

into

group Treatment

iqela lolawulo

Izibalo c 2

ixabiso P-

N

amacala Ukunyamalala

izinga Ukunyamalala (%)

N

amacala Ukunyamalala

Izinga Ukunyamalala (%)

fever

43

36

83.7%

41

25

61,0%

5,461

0,019

ukukhathala

31

19

61,3%

35

12

34.3%

4,813

0,028

ukhohlokhohlo

37

23

62.2%

39

14

35,9%

5,243

0,022

 

2.3  Ukuthelekiswa ixesha yokuduka khadinali uphawu phakathi kwamaqela amabini ezigulane

Kukho 36 izigulane qete kwiqela unyango aba, kunye ixesha eliqhelekileyo fever leentsuku (2.9 ± 1.67). Kukho iimeko 19 ukudinwa yaphela, kunye ubude avareji yeentsuku (3.5 ± 1.50) nabo. Uphawu lwe ukhohlokhohlo unyamalale kwiimeko-23, yaye ixesha eliqhelekileyo (3.9 ± 1.98). Iqela lolawulo ibe izigulane 25 nangecesina Ukunyamalala, kunye ubude avareji yeentsuku (3.9 ± 1.29), iimeko ezili-12 ukudinwa yokuduka, kunye ixesha eliqhelekileyo (4.8 ± 1.53) iintsuku, kunye ukhohlokhohlo Ukunyamalala kwiimeko-14, kunye avareji ixesha leentsuku (5.2 ± 1.76). Iimpawu eziphambili (ifiva, ukudinwa, ukhohlokhohlo) yanyamalala kwiqela unyango ngokukhawuleza kunalawo iqela lolawulo, kwaye umahluko phakathi kwamaqela baba ngokwamanani (P <0.05). Bona Table 3.

Table 3 Ukuthelekiswa ixesha yokuduka khadinali uphawu phakathi kwamaqela amabini

into

group imithi

iqela lolawulo

Statistics

t

ixabiso P-

N

Umphumela (iintsuku)

N

Umphumela (iintsuku)

fever

36

2.9 ± 1,67

25

3.9 ± 1.29

-2,453

0,017

ukukhathala

19

3.5 ± 1,50

12

4.8 ± 1,53

-2,342

0,026

ukhohlokhohlo

23

3.9 ± 1,98

14

5.2 ± 1,76

-2,083

0,045

 

2.4  Ukuthelekiswa Impumelelo Iimpawu eziphambili e Two Groups of Izigulane

Emva kweentsuku 7 zonyango, 44 ​​izigulane 51 kwiqela unyango aba olusebenzayo ekunyangeni iimpawu eziphambili, kunye ngereyithi esebenzayo 86.3%; 35 lezigulana 51 kwiqela kolawulo baphumelela kuwaphatha iimpawu eziphambili, kunye ngereyithi eyiyo 68.6%. Umahluko phakathi kwala maqela mabini ngokwamanani (P = 0.033).

2.5  Ukuthelekiswa izinga yokuduka ezinye iimpawu nemiqondiso phakathi kwamaqela amabini ezigulane

data Isiseko: amatyala 51 kwiqela imithi, kubandakanywa amatyala 9 iintlungu kwezihlunu (17.7%), iimeko 20 isikhohlela (39.2%), amatyala ayi-13 ka ukuphelelwa ngumphefumlo (25.5%), iimeko 11 of esifubeni yengxinano (21.6%) , kunye namatyala 3 dyspnea (5,9%), iimeko 7 isicaphucaphu (13.7%), iimeko-23 zokulahleka wokutya (45.1%), 22 amatyala bomzimba emanzi emiphungeni (43.1%); amatyala 51 kwiqela imithi, kubandakanywa amatyala 11 intlungu kwezihlunu (21.6%), iimeko 19 isikhohlela (37.3%), iimeko 14 ukuphelelwa ngumphefumlo (27.5%), iimeko 19 esifubeni yengxinano (37.3%), amatyala 7 of dyspnea (13.7%), iimeko ezi-5 isicaphucaphu (9.8%), 26 amatyala zokulahleka wokutya (51.0%), kunye namatyala 23 ufume yemiphunga (45.1%). Kwakungekho zamanani umahluko omkhulu phakathi kwamaqela (P> 0.05). ② Emva kweentsuku 7 zonyango, iimeko ezili-11 (55.0%), iimeko-8 (61.5%), iimeko ezi-6 (54.6%), kunye namatyala-8 (34.8%) kunye namatyala-10 (45.5%) of isikhohlela, ukuphelelwa umoya, esifubeni yobunzima, ukungabi namdla, kwaye iimpawu ngamathontsi, ngokulandelelana, unyamalale kwiqela imithi. ), Lo gama, iimeko ezi-3 (15.8%), iimeko ezi-2 (14.3%), iimeko ezi-3 (15.8%), iimeko ezi-2 (7.7%), kunye iimeko ezi-3 (13.0%) unyamalale ngokukwanjalo kwiqela lokulawula. Umahluko baba ngokwamanani (P <0.05); Intlungu imisipha, dyspnea kunye isicaphucaphu, iimeko ezi-6 (66.7%), iimeko ezi-2 (66.7%), kunye namatyala-4 (57.1%), ngokulandelelana, unyamalale kwiqela imithi, lo gama iimeko ezi-2 (18.2%), iimeko ezi-2 (28.6 %), kunye namatyala 2 shwaka kwiqela le kulawulo (40.0%). Kwakungekho mahluko manani phakathi kwala maqela mabini (P> 0.05). Bona Itheyibhile 4.

Table 4 Ukuthelekiswa izinga yokuduka ezinye iimpawu nemiqondiso phakathi kwamaqela amabini ezigulane

into

group Treatment

iqela lolawulo

Statistics

c 2

ixabiso P-

N

Inani lamatyala unyamalale

Disappear-

ulo

izinga

N

Inani lamatyala unyamalale

Disappear-

ulo

izinga

ubuhlungu muscle

9

6

66,7%

11

2

18.2%

-

0,065

yesikhohlela

20

11

55,0%

19

3

15.8%

6,510

0,011

Ukuqhawukelwa ngumphefumlo

13

8

61,5%

14

2

14.3%

-

0,018

esifubeni yobunzima

11

6

54,6%

19

3

15.8%

-

0,042

dyspnea

3

2

66,7%

7

2

28.6%

-

0,500

isizothe-zothe

7

4

57.1%

5

2

40,0%

-

1,000

Ukuphelelwa ngumdla wokutya

23

8

34,8%

26

2

7.7%

-

0,032

bomzimba emanzi

22

10

45.5%

23

3

13.0%

5,750

0,016

 

2.6  Uhlalutyo yengxinano utshintsho phakathi kwamaqela amabini ezigulane ngexesha unyango

Phakathi amatyala 51 kwiqela imithi, amatyala-4 (7.8%) ziye zaguqulelwa kakhulu ebudeni unyango, lo gama phakathi amatyala 51 kwiqela kolawulo, amatyala 11 (21.6%) baguquka esiqatha. Kwakukho umahluko ngokwamanani phakathi kwamaqela (P <0.05).

2.7  Ukuthelekiswa umfanekiso semiphunga (CT) iirhafu ukuphucuka phakathi kwala maqela mabini

Emva kweentsuku ezisi-7 unyango, 51 izigulane kwiqela imithi wabonisa amatyala 28 yophuculo lung CT (54.9%), lo gama-51 izigulane kwiqela kolawulo amacala 23 yophuculo CT yemiphunga (45.1%). Kwakungekho umahluko omkhulu phakathi kwamaqela (P> 0.05).

3        Ingxoxo

COVID-2019 kukho syndrome lwezonyango kunye etsolo izifo ezosulelayo zemiphunga njengoko iimpawu eziphambili zibangelwa yi-SARS-selwe-2, nto leyo eye nyonke Class B sisifo esosulelayo kwaye ilawulwa ngokungqinelana Class A sisifo esosulelayo e-China. Kutshanje, ngokusekelwe inwebu lung kwesidumbu ukufa Kwimeko yokuqala COVID-2019, kwaye kwafunyaniswa ukuba ukuhlangabezana neenqobo zovavanyo zoko ezihlasela zosulele ngokuphefumla Distress Syndrome (kwengozi), kunye ngezifo imiphunga uvavanya iziphumo ezifanayo SARS kunye zezi- [22] . Kukho ubungqina bokuba i-SARS-selwe-2 a RNA HIV-chain imvulophu coronavirus-ndixakene abangatshatanga kunye nee-enzayim bayo babe kumgangatho ophezulu ulandelelwano ezifana abo SARS kunye zezi-. Uhlaziyo Isakhiwo protein ibonisa ukuba ichiza ziyabophelela "pocket 's ka-2019-nCoV, SARS kunye zezi- enzayim intsholongwane ukuba igcinwe kakhulu. Ngokunjalo kubhaliwe ucingela ukuba amachiza zangaphambili anti-SARS kunye zezi- ungasetyenziswa unyango COVID-2019 [23] . Kungokunje, le zamayeza onyango kufuneka bajolise kwi-SARS-selwe-2 kwangumqondiso kunye nokusebenzisa ezixhasayo. Nangona ukuphuhliswa nechiza elichasene-viral lenze inkqubela enkulu, ke, SARS-selwe-2 yintsholongwane novel kunye nokuphuhliswa kwamachiza amatsha esele zenziwe kwaye ekujoliswe kuzo ziya kuthatha ixesha elide. Oku ngenene enye imiqobo ebangela ukulibaziseka lweenkcukacha le inflection indawo in ukuthintelwa nokulawulwa kwindawo bhubhane. Kusekho inkxalabo malunga ubungqina yezonyango esebenzayo kunye uxabane le okwangoku bezonyango izilingo ichiza osetyenziswa anti-virus okanye anti-nemalariya. Xa imeko yokungabikho olusebenzayo anti-SARS-selwe-2 iziyobisi, sifanele esiyifundayo kwindima ebalulekileyo ukuhlanganiswa amayeza emveli ase-China kunye namayeza Koloni nokuthintela kunye nolawulo SARS uze uwasebenzise ngokupheleleyo imfundiso ngokupheleleyo bemveli Chinese Medicine ukuxoxa ixabiso isicelo bezonyango Chinese Traditional Medicine ekuthintelweni kunye nonyango lwe COVID-2019.

Le COVID-2019 bobabo i "Epidemic Izifo" kudidi Chinese Medicine, ezininzi iingcali zamayeza Chinese bakholelwa ukuba esi sifo enxulumene iimpawu ilandelayo imishini uxilongo amayeza, kuqukwa ngamathontsi, ubushushu, ityhefu, stasis igazi, kwakunye ukuswela namandla, turbidity yoluvo kunye ngamathontsi [26-27] . I yemveli Chinese Medicine Lianhuaqingwen philisi (Granule) yi Medicine Innovative Chinese ummeli ekunokusetyenziswa imfundiso sifo collateral amayeza emveli ase-China ukutyhila indlela ukudluliselwa wentsholongwane izifo isixokelelwano sokuphefumla ntsholongwane-uqhutyelwe. Le nto ndiyibhalayo Weeks, forsythia bakhathazeka, yosiwe Ephedra, Krakra Almond, Isichumisi, Patchouli, Rhodiola, Rhubarb njalo njalo. Imisebenzi yala macandelo ziyangqinelana Pathogenesis ekhankanywe apha ngasentla esi sifo. Ifomula ayo asekelwe usebenzise Shigan decoction apha imbali Zhang Zhongjing ngomhla Febrile Izifo Han Dynasty kunye Yinqiao powder in imbali Wu Jutong ku bhubhane febrile izifo Qing Dynasty, esalo namava ekunyangeni izifo bhubhane yi "ukuvula umnyango drive kude isela "yaye" pathogen makhaya kufuneka expulsed kwangethuba kangangoko kunokwenzeka '. Inqanaba lokuqala usebenzisa iyeza, ubushushu bekhululwe kwanangezibilini kwaye kuhlambulula emiphungeni, ukusetyenziswa Rhubarb, le kuhlambulula kwe kwanangezibilini kunye kuhlambulula emiphungeni, nokuthotywa kwemiphunga-qi, kwaye indibanisela Patchouli kunye ivumba kunye ngamathontsi, kuba le meko bhubhane, kukho ukungaphatheki zesisu ngamathontsi kwizigulane kunye ngempumelelo ezibalulekileyo. Ngelo xesha, ukuba zokungahambisani Rhodiola kunye umsebenzi walo 'ababumba ukuswela "(" zokuXabangela Records of ugqirha odumileyo "), kuvulela wemiphunga asuse stasis igazi, ulungise sifo, ihlanganise le amakhosi ezintathu unyango imithi yamandulo" isifo bhubhane "amava practical. Uphononongo lubonise ukuba udibaniso lwe Weeks kunye Forsythia nempembelelo kwezonyango kwi COVID-2019, evimba iziza ezininzi olubophelelayo Angiotensin-ukuguqula enzyme kunye SARS-selwe-2 emzimbeni. Patchouli uyakwazi ukukhusela isakhiwo kunye nomsebenzi iiseli wamathumbu epithelial, ukuphucula umsebenzi isithintelo isisu, ngcono iimpawu ukurhuda hypersensitivity visceral [29] . Rhodiola kwifomula unako ukuphucula kakhulu ukusebenza kwemiphunga, ukuphucula hypoxia unyamezelwano kunye noxinzelelo kwenxenye ioksijini igazi, ukuphucula kakhulu umphunga inyama hypoxia-uqhutyelwe umonakalo yezifo. Kunokuba ngcono okuqhubekayo hypoxic ukwenzakala lung, ukunciphisa nokudumba yemiphunga, kwaye zinqanda indlela yokukrala esiqwini wemiphunga ngokuthi ziyibuyisela stress oxidative kunye apoptosis, kunye nokuphucula umsebenzi omzimba. Studies wabonisa ukuba rhubarb ukuba kunganqanda SARS-selwe-2, zinqanda phezu-amazwi zinto ukudumba e esiqwini lung, ukunciphisa ukwenzakala emiphungeni, kunye nokwandisa amandla anti-igcwala, ukukhusela umsebenzi pulmonary micro-nemithambo isithintelo, nokunciphisa nokudumba pulmonary .

Kudityaniswe ngamava uphando olungundoqo kunye kwezonyango Lianhuaqingwen, iziphumo yabonisa ukuba Lianhuaqingwen akwazi kakhulu anqanda SARS-selwe kwizisele cultured, ukongezelela H1N1, H3N2, H7N9 kunye nezinye iintsholongwane influenza. It zinganciphisa nucleic ixesha asidi entle wentsholongwane izigulane komkhuhlane a (H1N1). Kwakungekho akukho mahluko ngexesha uxolelo lwezo zonke iimpawu umkhuhlane xa kuthelekiswa naleyo Oseltamivir phosphate, ngoxa icesina yehla kakhulu kwaye iimpawu ukukhohlela, ukuqaqamba kwezihlunu nokudinwa gidi ngempumelelo [45-46] . Ngoko ke, i data lwezonyango izigulane 102 kunye NCP zaqokelelwa kukuhlalutya isiphumo Lianhuaqingwen granule kudityaniswe unyango yesiqhelo kwi ifiva, ukudinwa, ukhohlokhohlo kunye nezinye iimpawu eziphambili, kwakunye nezinga ukuphuculwa Lung CT ukwenzela ukunika isiseko lophando lwezonyango ngokuba oludibeneyo unyango yaseTshayina kunye Western amayeza esi sifo.

Idatha zonyango lwezigulane baphathwa iintsuku 7 zahlalutywa ukuqalela ngokubhekisele iikhrayitheriya zokuxilonga eqhelekileyo [15] yeKomiti yeSizwe lezeMpilo-ncov 2019 ukuze pneumonia. Iziphumo zabonisa ukuba Lianhuaqingwen granules ababa ngokucacileyo ukuphucula iimpawu kwezonyango ifiva, ukudinwa, ukhohlokhohlo, phlegm, ukuphelelwa umoya, esifubeni yengxinano kunye nelahleko namdla. Izinga ngempumelelo yokuphucula iimpawu ifiva, lidiniwe ukhohlokhohlo yaba 86.3%. Kwakhona zanciphisa umlinganiselo lokuguqula ukusuka uhlobo eqhelekileyo uhlobo kakhulu ngempumelelo. Iintsuku Ukunyamalala kwe ifiva, lidiniwe ukhohlokhohlo kwakukho iintsuku 2.9, iintsuku 3.5 neentsuku 3.9 ngokulandelelanayo, nto leyo elifutshane ixesha iqela lolawulo ehambelana emini 1, iintsuku 1.3 kunye neentsuku 1.3. Iziphumo zabonisa ukuba Lianhuaqingwen granule nako ngokucacileyo ukuphucula iimpawu lwezonyango. Nangona kungekho mahluko kakhulu kwezinga ukuphuculwa CT kwi kwemiphunga phakathi kwala maqela mabini, isicelo odibeneyo Lianhuaqingwen Granules wabonisa umkhwa othile entle. Uhlalutyo lokuqala lweziphumo ngentla ibonisa indlela ulwalamano olusondeleyo kokukhethiweyo amacandelo kunye zidityaniswe ngokusekelwe kwithiyori isifo ngummeli wowona TCM kunye indlela pharmacodynamics. Xa imeko okusileleyo olusebenzayo anti-SARS-selwe-2 iziyobisi, ukuqeshwa iingenelo theoretical component compound Chinese Medicine iimpawu, oko kukuthi "ummiselo ngokubanzi, unyango multi-ekujoliswe" Unganciphisa imeko kwaye ngok ekuhambeni sifo. Kufuneka metioned ukuba isifundo eziqokelelwe iinkcukacha zonyango evela NCP waqinisekisa izigulane ziye iyakuqinisekiswa isikhohlela, swab umqala okanye athobe nokuphefumla iphecana secretion ubhaqo asidi acid ngoJanuwari 2020. Ngenxa yokunqongophala kweekhithi kunye namanye amawonga, NCP nucleic acid ukuvavanya perfromed kuphela kwezinye izigulane emva konyango esibhedlele. Ezilishumi (10) izigulane kwiqela unyango yabuya elibi kunye nezigulane 7 kwiqela kolawulo wenza. Ngaphambi kokuba wenze isigqibo esiqinileyo kuso kuyimfuneko ukwenza isifundo kutshata, lulingo lwezonyango ukuvavanya nangakumbi ukusebenza kwezonyango ukusetyenziswa odityanisiweyo ka-Chinese Medicine Lianhuaqingwen kunye nonyango oluqhelekileyo.

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