Ukuqwalasela lwezonyango ka 63 lweemeko ezikrokrelekayo Inoveli Coronavirus inyumoniya ezinyangiweyo ne-Chinese Traditional Medicine Lianhuaqingwen njengezingxobo

Ruibing Nqulo, wenju Wang, Xin Li

CR & WISCO Hospital General of Wuhan University of Science and Technology, 209 avenue metallurgical, kwisithili Qingshan, Wuhan 430080, Hubei kwiphondo, China

[Abstract] O bjective: emva nokuvavanya ukusebenza bezonyango Lianhuaqingwen ekunyangeni lweemeko ezikrokrelekayo inoveli coronavirus pneumonia. Indlela Ukuqokelela 101izigulane ngubani ekurhaneleka amatyala waza wamkelwa CR & WISCO General Hospital of Wuhan University of Science and Technology kwaye ekucingelwa bethe bayifezekisa le miqathango diagnostic ukuba semiphunga coronavirus entsha esuka Jan 1 th ku Jan 27 th . Phakathi 101 izigulane, 63amatyala kwiqela imithi ziphathwa ngokudibanisa unyango aqhelekileyo (unyango inkxaso okunesondlo, unyango kwangumqondiso, unyango antiviral kunye elwa), ukuthatha amayeza emveli ase-China Lianhuaqingwen njengezingxobo. Kwiqela kolawulo, 38amatyala anikwa kuphela unyango oluqhelekileyo. Data Clinical zaqokelelwa emva 10kweentsuku yonyango, kwaye iimpawu eziphambili (umkhuhlane kunye ukhohlokhohlo) amaqela amabini kuthelekiswa, umyinge Ukunyamalala, ubude ifiva, iirhafu Ukunyamalala kwezinye uphawu olulodwa kunye mqondiso. Iziphumo Xa kuthelekiswa neqela lolawulo, izinga yokuduka ifiva, ukhohlokhohlo nokudinwa iimpawu kwiqela imithi yaba 86,7% , 55,6% , 82,5% ngokulandelelana, ngaphezu iqela kolawulo (kakhulu baba 677% , 30,6% , 58,6 % ) ( P <0.05 ). Ubude median fever yaba 6iintsuku kwiqela unyango kunye 7iintsuku kwiqela lokulawula. Kwakungekho ukubaluleka manani ukuba umahluko phakathi kwala maqela mabini ( P = 0.171 ). Izinga Ukunyamalala Ukunyamalala tachypnea kwaye ufumile rales kwiqela imithi ( 68.2% kunye 56,0% ngokulandelelana kwawo) kakhulu ngaphezu iqela lolawulo ( 20.0% kunye 20. 0% ngokulandelelana) ( P <0.05 ) .Le iqela unyango saba sibi kakhulu amatyala 4 ( 6.4% ) kunye neqela lolawulo kwiimeko-6 ( 15.8% ). Kwakungekho ukubaluleka manani ukuba umahluko ( P > 0.05 ), kodwa nentsingiselo ngokucacileyo ngaphantsi kunolo olulawulayo qela. Isiphelo I yemveli yeza Chinese Lianhuaqingwen ephelisa kakhulu iimpawu kwizigulane ekukrokrelwa yi ziyibuyisela umkhuhlane, ukhohlokhohlo asthenia kunye isifuba ingxinano njengoko kwakunye nokunciphisa inani amatyala kakhulu sakujika.

[Amagama angundoqo] Lianhuaqingwen; inyumoniya coronavirus inoveli; lweemeko ezikrokrelekayo; isifundo clinical;

NgoJanuwari 31 th 2020, i-World Health Organization sathi ukuba inoveli udidi coronavirus inyumoniya, ukusasazwa zehlabathi NCP) Rapid unenze unxunguphalo jikelele, yaye adweliswe njengento engxamisekileyo kwimpilo yoluntu inkxalabo ngamazwe. Kuba omnye loqhambuko enkulu kakhulu yingozi kwimpilo yoluntu kunye nokhuseleko loluntu. Idatha wakhulula yiKomishoni National Health and Health [2] , njengoko ka Februwari 7 24:00, amaphondo 31 kunye noomasipala amacala 34,546 ozinzisiweyo, kwakukho 27,657 lweemeko ezikrokrelekayo, kunye olulandelayo-up oluqhelekileyo amatyala 345498. Kukho abantu 18960 sempilo. Ibale ukuqinisekisile amacala, izinga kungqinwa lweemeko ezikrokrelekayo yi-12.9%. Eko sifo, ngokutsho IXINHUA News Agency disclosure ngoJanuwari 27, 2020, Izinga waqinisekisa unako ukufikelela kwi-45% [3] , leyo abe enokubakho ingozi factor. I nucleic HIV acid lovavanyo pharyngeal lasetyenziswa iinqobo zokuxilonga, kodwa kusekwangoko, ukugqabhuka imeko bhubhane, kwakukho ubonelelo zaneleyo kwekhithi, libya ubungakanani uhlolo yemihla ngemihla Ubhaqo lokumisa azichanekanga, konke oku isandla ekubeni kubekho inani elikhulu lweemeko ezikrokrelekayo zange sifo e kwexesha. Kwaye oku kwenza ukuba akukwazi ukuyilawula ngokukhawuleza ukuze inyumoniya coronary kwinoveli kwi kumabakala okuqala, inflection isifo indawo fail ukuze kungafunyanwa kwexesha. Ngoko ke, nucleic acid eyandileyo lweemeko ezikrokrelekayo. Detection, ukukhawulezisa uxilongo lwezonyango, ngokukhawuleza athathe amanyathelo awodwa [4] , baze basebenzise amayeza emveli ase-China ukuba bathathe inxaxheba kule nkqubo yonyango lweemeko ezikrokrelekayo ngexesha [5] , leyo zokubaluleka enkulu ukuvimbela bhubhane kunye nolawulo.

Amayeza emveli ase-China oye wadlala indima ebalulekileyo kwaye itsale ingqalelo kakhulu ngexesha sifo isibetho kunye bhubhane qwele xesha, njengokuba amayeza Chinese ummeli zemveli kwinkqubo nokuphefumla iziganeko yezempilo karhulumente [6] , Lianhuaqingwen Capsules (Granules) were recommended for medical observation period in <Pneumonia Diagnosis and Treatment of New Coronary Virus Infection> (Trial Editions 4 and 5)[5,7] by National Health Commission of the People’s Republic of China. Meanwhile, Health Commission of the People’s Republic of Wuhan <The Therapeutic Regimen for Novel Coronavirus Infection Recommended Scheme for Home-Based Prevention Of Pneumonia>[8] sinyusa abantu basoloko sinotyekelo nangokurhala, umqala obuhlungu, kwaye isetyenziswa kunyango abantwana ixesha sempilo [9] . Ngoko ukususela kokuqhambuka bhubhane, ndacinga ityala NCP, ukuhlanganiswa Lianhuaqingwen Granules edibene nonyango routine wafumana ukusebenza kakuhle unyango, i-data kwezonyango amatyala zishwankathelwe ngolu hlobo lulandelayo ngenjongo ukunika isiseko lwezonyango ukuba unyango lwe kuyakrokreleka izigulane.

1 Ulwazi Clinical

1.1 Iinqobo sokuxilonga

Refer to the guidelines for the diagnosis of suspected cases of <Diagnosis and Treatment of Pneumonia with Novel Coronavirus Infection> (Trial Version 4)[7] . Nawuphi na omnye umba imbali bhubhane kuquka ukhenketho, zokuhlala, qhagamshelana, udibaniso, naziphi na izinto ezimbini kwezi mpawu zonyango eziquka umkhuhlane kunye / okanye iimpawu zokuphefumla, leukocyte ekuqaleni iyonke / eliqhelekileyo zehla / decreasedlymphocyte lwamajoni NCP ziyakwazi ukuchongeka umfanekiso njengoko lweemeko ezikrokrelekayo.

1.2 Iikhrayitheriya Ukubandakanywa

Makhe ngaphezu iindlela zokuxilonga lweemeko ezikrokrelekayo oneminyaka eli -18 apha ngentla, kunyangwe kunye NCP iimpawu imifanekiso.

1.3 Iikhrayitheriya okungayi  

, Ezimandundu kakhulu NCP izigulane une; isifuba inyumoniya, isifuba X -ray ngekhompyutha Itomography izixhobo ( CT ) qinisekisa kukho amanxeba Embi pulmonary kakhulu, bronchiectasis kunye nezinye izigulane zemiphunga ezisisiseko kunye nesifo; ezinxulumene nesifo kakhulu immunodeficiency, iziphene nokuphefumla iphecana malformation, isifo sentliziyo azalwa, uphuhliso kwemiphunga engaqhelekanga kunye nezinye izifo ezingundoqo.

1.4 Inkcazelo ngokuthe gabalala

101 okusolwayo NCP izigulane ziphathwa kwi CR & WISCO General Hospital of Wuhan University of Science and Technology ukususela ngoJanuwari 1 th January 27 th , 2020 yaqokelelwa. Phakathi kwabo, 38amatyala banikwa amayeza lwasentshona ukuyilandela iqela lolawulo. Iqela lonyango ibe 63 iimeko zonyango edityaniswe Lianhuaqingwen Granules. Kwakungekho ukubaluleka manani ukuba umahluko data baseline kuquka ubudala, isini, ubushushu bomzimba, uxinzelelo lwegazi, izinga intliziyo, yokuphefumla, ezidlulileyo History, ifiva, ukudinwa, ukhohlokhohlo kunye nonyango yesiqhelo, izalathisi elebhu Ukuhlolwa enkulu njalo phakathi kwala maqela mabini ( P > 0.05 ), ke iyathelekiswa. Bona Itheyibhile 1.

 

Tabel 1 Ukuthelekiswa data jikelele phakathi kwala maqela mabini

izinto

Iqela Unyango (amatyala 63)

Iqela Control (amatyala 38)

P

Age

59,1 ± 16,56

60,2 ± 17,01

-0,309

0,758

[Amatyala (%)] Ubudoda

28 (44.4)

18 (47.4)

0,082

0,775

ubushushu

38,08 ± 0,63

38,08 ± 0,67

0,318

0,751

Izinga Heart [Times / min,]

88,5 ± 15,43

87,6 ± 13.13

0,305

0761

Breath [Times / min,]

19.4 ± 2.03

18.8 ± 1,65

1,315

0,192

Anamnesis [amatyala (%)]

42 (66.7)

28 (73.7)

-

0,628

kwegazi

21 (33.3)

11 (28.9)

0,211

0,646

isifo sentliziyo

8 (12.7)

3 (7.9)

-

0,528

Diabetes

5 (7.9)

6 (15.8)

-

0,323

iqhosha Cerebral

10 (15.9)

5 (13.2)

0,138

0,710

fever

60 (95.2)

34 (89.5)

-

0,421

ukukhathala

40 (63.5)

29 (76.3)

1,801

0,180

ukhohlokhohlo

54 (85.7)

36 (94.7)

-

0,201

unyango lomhla nezolo [amatyala (%)]

antibiotics

55 (87.3)

34 (89.5)

-

1,000

Antivirus

54 (85.7)

32 (84.2)

0,042

0,837

analgesia Antipyretic

31 (49.2)

17 (44.7)

0,190

0,663

Immunoglobulin

33 (52.4)

19 (50.0)

0,054

0,817

Expectorant

54 (85.7)

32 (84.2)

0,042

0,837

Iziyobisi Antiasthmatic

35 (55.6)

22 (57.9)

0,053

0,818

Glucocorticoid

23 (36.5)

13 (34.2)

0,055

0,815

Amhlophe egazi

4,62 ± 2.14

4,42 ± 2,32

-0,441

0,330

Neutrophil

67,09 ± 14,08

65,52 ± 14.8

-0,524

0,301

lymphocyte

22.28 ± 11.15

20.12 ± 12,65

-0,896

0,186

C-reactive protein

 

51,50 ± 46,05

50,41 ± 45,27

-0,116

0,454

2 Indlela

2.1 Treatment

Omabini amaqela anikwa inkxaso okunesondlo, unyango kwangumqondiso kanye unqulo kunye nonyango elwa. Ichiza ephambili unyango moxifloxacin ziphene sodium hydrochloride ( 250 ml: 0/4 g , apho iveliswa Chengdu Zhengkang Pharmaceutical Co., Ltd , lot number is 3419111102) 0.4 g, once a day; ganciclovir injection (5 ml: 250 mg per dose which is produced by Hubei Keyi Pharmaceutical Co., Ltd. Production, lot number 191003) 0.5g, once a day, Intravenous injection of human immunoglobulin (2.5 g/bottle, Guizhou Tai Bong Biological Products Co., Ltd., lot number 201906026) 2.5 g, once a day; ambroxol hydrochloride injection (2 ml: 15mg/pill, Tianjin Pharmaceutical Group Co., Ltd., lot number 1906116) 30 mg, twice a day; doxotheophylline for injection (0.2 g/bottle, Ruiyang Pharmaceutical Co., Ltd., lot number 19082116) 0.2 g , once a day; methylprednisolone sodium succinate for injection (40mg/bottle, produced by Liaoning Haiske Pharmaceutical Co., Ltd, lot number 20191027)40 mg, once a day.

Iqela Control: banikwe nje unyango ngasentla.

Iqela Unyango: ngokwesiseko unyango ngentla ezidityanisiweyo kunye granules Lianhuaqingwen ( 6 g ingxowa nganye, kuquka forsythia, Weeks, neflakisi, iiamangile eqhotsiweyo, Isichumisi, Radix Isatidis, Cotton Horse, Houtttuynia, Patchouli, Rhubarb, Rhodiola, njl, ilingana ku 8.064 g amayeza ekrwada, eziveliswe YiLing Pharmaceutical Co., Ltd, inombolo iqashiso 1812017), ingxowa enye kanye kwexesha, kathathu ngemini.

Qokelela idatha lwezonyango.

2.2 Uqwalaselo Izalathisi Iindlela

2.2.1 Thelekisa yokuduka iimpawu eziphambili maqela mabini (ifiva, ukudinwa, ukhohlokhohlo) umyinge Ukunyamalala, ixesha fever Ukunyamalala kunye nezinye uphawu olulodwa kunye nemiqondiso (myalgia, expectoration, snuffles, impumlo esihambisayo, umqala obuhlungu, tachypnea, isifuba ukuxinana, dyspnea, intloko, isicaphucaphu, ukugabha, ukudla, urhudo, rales emanzi), unyango kuxhotyiwe imeko ngexesha unyango.

2.2.2 Ukhuseleko yovavanyo Khangela yesiqhelo igazi, umchamo lwesiqhelo, isitulo eqhelekileyo, umsebenzi umchamo isibindi kunye nokusebenza kwezintso phambi nasemva unyango.

2.3 Iindlela Statistical

Software ye SAS9-4 yasetyenziselwa analysis manani. Zonke iimvavanyo-manani bavavanywa bilaterally, kwaye idata ukubalwa uhlalutyo oluneenkcukacha bekusithiwa kwaye umlinganiselo ubume ukuchaza, iinkcukacha yemilinganiselo kuchazwa by ± ecaleni standard ukuchaza. T sasetyenziswa ukufaniswa kwe data womlinganiselo kunye chi-square uvavanyo okanye ngqo indlela amathuba yasetyenziswa idatha ukubala. Survival Uhlalutyo ndlela yasetyenziswa ixesha umkhuhlane. P 0.05 indicates that it has statistically significant.

iziphumo 3

3.1 Ukuthelekiswa izinga yokuduka iimpawu eziphambili phakathi kwamaqela amabini

Itheyibhile 2 ubonisa ukuba iimpawu ifiva, ukhohlokhohlo nokudinwa kwiqela unyango aba ngcono kakhulu kunalawo iqela le kulawulo ( P <0.05).

Table 2 Ukuthelekiswa imeko Ukunyamalala iimpawu eziphambili phakathi kwamaqela amabini [amatyala (%)]

Groups

fever

ukhohlokhohlo

ukukhathala

amatyala

Ukunyamalala

amatyala

Ukunyamalala

amatyala

Ukunyamalala

Treatment Group

60

52 (86.7)

54

30 (55.6)

40

33 (82.5)

control Group

34

23 (67.6)

36

11 (30.6)

29

17 (58.6)

X 2

4,868

5,443

4,804

P

0,027

0,020

0,028

3.2 Ukuthelekiswa ithuba fever phakathi kwamaqela amabini

Bekukho 52 izigulane nangecesina kwiqela unyango kunye nexesha udibaniso fever iintsuku-6; kwakukho 23 izigulane nangecesina kwiqela kolawulo kunye nexesha udibaniso fever kwiintsuku ezisi-7. Kwakungekho ukubaluleka manani ukuba umahluko phakathi kwala maqela mabini ( P = 0.171).

3.3 Ukuthelekiswa kwezinye iimpawu kunye yokuduka kweempawu ebalulekileyo phakathi kwala maqela mabini

Uluhlu 3 sibonisa ukuba izinga yokuduka tachypnea kunye rales emanzi kwiqela imithi iphezulu kakhulu kunaleyo kwiqela kolawulo ( X 2 = 9.817, 4.972), yaye kwakukho nokubaluleka manani ukuba umahluko phakathi kwala maqela mabini ( P < 0.05); Kwakungekho ukubaluleka manani ukuba umahluko ezinye iimpawu phakathi kwala maqela mabini ( P > 0.05)

3.4 ukuqhubela lokugula ngexesha yonyango maqela mabini

Ngexesha unyango, kwakukho izigulane-4 (6.3%) kunye nesifo advanced kwiqela imithi (amatyala 63), kunye nezigulane-6 (15.8%) kunye nesifo advanced kwiqela wolawulo (amatyala 63). Kwakungekho ukubaluleka manani ukuba umahluko phakathi kwala maqela mabini ( P > 0.05).

 

Table 3 Ukuthelekiswa ezinye iimpawu kunye yokuduka kweempawu ebalulekileyo phakathi kwala maqela mabini

izinto

Treatment Group

control Group

X 2

P

amatyala

Ukunyamalala

amatyala

Ukunyamalala

Myalgia

9

7 (77.8)

7

4 (57.1)

-

0,596

Expectoration

42

24 (57.1)

23

11 (47.8)

0,519

0,471

Snuffles

3

2 (66.7)

4

3 (75.0)

-

1,000

Impumlo enemifinya

6

5 (83.3)

3

3 (100.0)

-

1,000

Umqala obuhkungu

3

2 (66.7)

3

1 (33.3)

-

1,000

Tachypnea

22

15 (68.2)

20

4 (20.0)

9,817

0,002

esifubeni Ingxinano

24

17 (70.8)

19

12 (63.2)

0,285

0,594

Dyspnea

12

6 (50.0)

9

1 (11.1)

-

0,159

ikhanda

6

5 (83.3)

6

4 (66.7)

-

1,000

isizothe-zothe

11

10 (90.9)

6

3 (50.0)

-

0,099

ukuphalaza

4

3 (75.0)

3

1 (33.3)

-

0,486

anorexia

48

36 (75.0)

30

19 (63.3)

1,209

0,272

urhudo

8

4 (50.0)

3

1 (33.3)

-

1,000

omanzi Rales

25

14 (56.0)

15

3 (20.0)

4,972

0,026

3.5 Uhlalutyo Security

Ngexesha unyango, ayizange ukubonisa nayiphi na imeko engaqhelekanga malunga yesiqhelo igazi, isibindi kunye umsebenzi kwezintso kwiqela unyango enxulumene Lianhuaqingwen Granules, yaye akufunyanwanga uxabane of Lianhuaqingwen Granules. Ukhuseleko isicelo yinto elungileyo.

4 Iingxoxo

Coronaviruses ziye zabangela izifo ezimbini ezinkulu isikali kule minyaka ingama-20 idlulileyo, ukuba SARS-selwe [10] kunye zezi--selwe [11] ngokulandelelana, nokosulela amawaka alishumi izigulane. Le lwegciwane le kwesifo ekupheleni kuka-2019 yaba 2019-nCoV (2019-nCoV), amaphononongo abonisa ukuba ukufana phakathi intsholongwane kwaye SARSs wayeneminyaka 89,1% [12] , kwaye lufumanise ukuba ukulandelelana ukufana ka 2019-nCoV kunye SARS-selwe BJ01 baba 79,5%, kwaye benayo Pathogenesis efanayo. Ixesha bafukanywe ukuba angene umzimba ekubeni ebegula "2019-nCoV" yi ~ iintsuku 1 14 [5] , kwi zigaba yokuqala kwesifo, nokubonelelwa ngeekhithi uvavanyo ekupheleni ukuqhambuka ibingonelanga kwaye kukho ubunzima ukuba izigulane ukuba unesifo [14] . Kude ku Februwari 7, 2020, kwakusekho kukho umsantsa amaziko bemizekelo eyimiqondiso kunye nabasebenzi [15] . Inani elikhulu lweemeko ezikrokrelekayo ayikwazi qinisekiswa ngenxa yokunqongophala kwenkxaso etiological. Kutshanje, inani lweemeko ezikrokrelekayo liye lanyuka ukuya ngaphezulu kwama-20,000, kunye nabafowunelwa close baye bafikelela 280 lamawaka, kunye 180 amawaka abantu zibekw 'esweni [2] . Okwangoku, akukho akukho amachiza olusebenzayo amatyala zoqhagamshelwano okukrokrelwayo kwaye akusondela, ngokuqaphela ekhaya kunye nonyango lwezonyango kwangumqondiso inkxaso ngokuqhelekileyo kusetyenziswa kwiklinikhi [5] , yaye oku kuye kwaba ngowona mthombo ingabonakaliyo usuleleko kunye yingozi factor, eyenza uthintelo kunye nolawulo imeko bhubhane e China bajamelana neengxaki ezinkulu, kunye namanyathelo kuthintelo kunye nolawulo kunye nemithi lweemeko ezikrokrelekayo kufuneka ibe umsebenzi ephambili uphando kwezonyango nezesayensi.

Kukho imbali amawaka eminyaka ekuthinteleni nokunyanga "izifo bhubhane" yi amayeza emveli ase, Njengokuba ekuqaleni kwi Spring kunye Autumn Ixesha kunye nexesha elwa States, oko kubhalwe kwi <Plain Umbuzo ?? Capter of Cifa> "Five indyikitya kuza, sonke isifo kwisigaba ngokulula, nokuba bangakanani na, iimpawu ezifanayo", kukho kwakhona abhale ukuba "Ngaphantsi nje kweminyaka sele idlule ukususela kunyaka wokuqala Jian'an, yaye-esithathwini abaye babulawa sifo, izahlulo zeshumi zibe sixhenxe kubo kusukela esifo "kwi <imbali kwi Ingqele Diseases Ukonakala> Zhongjing Zhang e Han Dynasty wadala uthotho ifomula odidi kuquka usebenzise Shigan Decoction ngokuba ukunyanga isifo esifo. In kaMing, i <ama kwi yokufa> of Youke Wu kuxoxwa nokuthintela kunye nolawulo yokufa, kukholelwa ukuba esi sifo sibangelwa "bhubhane izinto yayintsholongwane eyosulela" kwaye ayihambi ngokusebenzisa umlomo kunye nempumlo, kwaye isifo esithile , Wu kudala Dayuan iziselo ukuba unyango lwezifo ezifana, kwaye applys ulawulo "Rhubarb ndimgxothe ububi layo". Kule Qing Dynasty, Tianshi Nina lamisela ulawulo ugqithiso igazi qi zokhuselo qi ngesondo amabakala ahlukeneyo nokuthintela kunye nokunyanga angaphandle Febrile Diseases, Jutong Wu kwi Qing Dynasty wasungula indlela unyango lwe syndrome umahluko ye Energizer kathathu ukuba ezisuka ngaphandle Febrile Diseases, ibonisa ukuba amayeza emveli ase-China wenze iminikelo enkulu nokuthintela kunye nokunyanga "isifo bhubhane" ukuqinisekisa ukuphumelela yesizwe Chinese. yonke indlela yalo bhubhane ubukhulu becala ngamathontsi-ubushushu ityhefu-stasis, kwaye uninzi lweemeko ezikrokrelekayo bephelekwa umkhuhlane kunye / okanye iimpawu zokuphefumla, ehambelana iirekhodi kunye nolwazi sifo amayeza emveli ase-China.

Lianhuaqingwen ifomula, isicelo kwithiyori sifo collateral in Chinese Traditional Medicine ukutyhila ulawulo ukudluliselwa isixokelelwano sokuphefumla ibangelwa yintsholongwane, wabeka forwar qhinga imithi of "Ukungenela", eziquka qi sokuzithethelela indlela efanayo, ekhupha amagciwane ezivela kokubini embindini kunye superficies, sonyango ngaphambi kokuba naziphi na iimpawu, badakile isakhono sifo, ulawulo ngokubanzi, unyango multi-ekujoliswe, unyango "ubushushu-ukususwa detoxifying nobushushu obhobhozayo ngokuthi umoya emiphungeni" yasekwa [16] . The formula is based on Maxing Shigan Decoction in the < Treatise on Cold Damage Diseases > of Zhang Zhongjing in Han Dynasty, and Yinqiao powder in the <Item Differentiation of Warm Febrile Diseases> of Jutong Wu in Qing Dynasty, defense qi with the same method, discharge heat by ventilating the lungs, at the same time, it also draw from the the experience of treatment of rhubarb from Youke Wu’s <treatise on pestilence> in Ming Dynasty, medicated before having any symptoms, discharge heat by ventilating the lungs, resolving dampness with aromatics by pogostemon cablin, wake up the spleen and the brain, clear the Lungs and resolve stasis with rhodiola rosea, regulate immune, the formula is to clear the toxic heat in the lung, diffuse the lung, cut off the disease potential, it embodies the experience of ancient prescriptions in the three dynasties in the treatment of exogenous pestilence. The drug composition of Lianhuaqingwen is coincident with the pathogenesis of the disease, It embodies the active therapeutic principle of “heat-clearing and detoxifying, discharge heat by ventilating the lungs, resolving dampness with aromatics”[17] . Izifundo pharmacodynamic Previous lubonise ukuba Lianhuaqingwen njengezingxobo kunganqanda amazwi ka-SARS-selwe kwizisele cultured in vitro [18] , kwangaxeshanye, H1N1, H3N2, H7N9 kunye nezinye iintsholongwane umkhuhlane zaye elinganeno kakhulu [19-20] . Ngexesha loqhambuko lwe H1N1, a lunomkhethe, iimfama kabini, ukufunda multicenter kwezonyango lwenziwa kwizibhedlele ezisithoba, ikhokelwa ngu-Uza An Hospital lwembali Capital Medical University, kwaqinisekiswa ukuba akukho mahluko phakathi Lianhuaqingwen njengezingxobo kunye Oseltamivir Phosphate ngexesha zentsholongwane nucleic acid ukwala ezimbi umkhuhlane uphawu ekhulula, ke Lianhuaqingwen njengezingxobo kakhulu kwanciphisa yengxinano sifo kunye nobude iimpawu, kuquka umkhuhlane kunye isiqabu of ukukhohlela, myalgia, ukudinwa. Ulingo zigqityiwe kwezonyango lunomkhethe, vula nezilungileyo ezilawulwa Lianhuaqingwen njengezingxobo kwi unyango Influenza A H1N1 [22] lubonise ukuba iyafana naleyo e Oseltamivir Ixesha ntsholongwane kugqiba ezingalunganga kwi Lianhuaqingwen njengezingxobo, iimpawu ezifana ukukhohlela, umqala obuhlungu, ukukhathala myalgia gidi ngokukhawuleza ngaphezu Oseltamivir, le yolingo lwezonyango okhankanywe ngentla-kuqinisekiswa ukuba Lianhuaqingwen kwi unyango kunye nolawulo bhubhane Influenza kuba livakale.

In this study, 101 patients from January 1th to 27th, in 2020 were admitted to the hospital as suspected cases according to the <diagnosis and treatment of pneumonia due to 2019-ncov infection (fourth edition)>[7] , chest radiographic examination showed the imaging features of pneumonia, which is now clinically diagnosed according to <diagnosis and treatment of pneumonia due to 2019-ncov infection (fifth edition)>[5] , emva konyango, idatha yokuthwebula ye ezinye izigulane ibhungane. Ngexesha unyango, 68 izigulane amaqela amabini zagonyelwa nucleic acid. Noko ke, ngenxa yokuba ubonelelo kweekhithi reagent kunye nezinye iingxaki, zonke izigulane ivavanywe hayi nucleic ngexesha, ngoko, ubhaqo asidi acid kange lifakwe kwisalathiso nokuvavanywa ukusebenza kuliyeza. Iziphumo zabonisa ukuba Lianhuaqingwen Granules unako ngokucacileyo ukuphucula iimpawu yezonyango kunye nemiqondiso ezinxulumene nesi sifo, ezifana ifiva, khohlo, ukudinwa, tachypnea kunye rales emanzi; Ngelo xesha, inani lezehlo kakhulu kwiqela imithi zibonise ukuhla kakhulu, ebonisa ukuba Lianhuaqingwen Granules abe ayasebenza elungileyo lwezonyango ukuba lweemeko ezikrokrelekayo ukuphucula iimpawu zonyango, lula yengxinano sifo, njalo njalo. Iziphumo zabonisa ukuba ixesha fever kwiqela unyango yaba emfutshane usuku olu-1 ngaphezu koko kwiqela kolawulo, nangona kwakungekho mahluko-manani, isiqhelo kwexesha kunciphisa kwakucaca, kwangaxeshanye ngayo yabonisa umkhwa omhle isiqabu of myalgia, expectoration, Chest ukuxinana, Dyspnea kunye nezinye iimpawu. Libonisa ukugqithisela uphawu 'ummiselo ngokubanzi, unyango multi-ekujoliswe "amayeza compound Chinese, yaye icebisa ukuba Lianhuaqingwen Granules uxabiseke lwezonyango ebalulekileyo lweemeko ezikrokrelekayo.

It should be noted that this study was a retrospective clinical study of patients collected and included according to the <diagnosis and treatment of pneumonia due to 2019-ncov infection (fourth edition)>[7] . Ubukhulu isampula encinane, iimfuno ukusebenza yezonyango ngqo ukuba kuvavanywa ezinkulu-isikali, kuba, olungenamkhethe olulawulwayo yolingo lwezonyango.

 

References

[1] World Health Organization, iNgxelo kweNtlanganiso Second weKomiti Emergency ye-nCoV 2019 kwi-International Regulations Health (2005) malunga 2019 pandemic, 2020-01-30. https: // www.who.int/zh/news-room/.

[2] Ofisi Health Emergency of Health Commission yeSizwe ye-Peoples Republic of China. Hlaziya kwi imeko yakutshanje yinyumoniya ezinxulumene ne-2019-nCoV njengoko ka 24:00 kusasa ngomhla we-7 kuFebruwari, 2020-02-08.

http: // www.nhc.gov.cn/xcs/yqfkdt/202002/6c305f6d70f545d59548ba17d79b8229.shtml.

[3] IXINHUA Agency News. Okwangoku, ubuchwepheshe virus ekufumanekeni unalo ixesha elide kakhulu, kwaye izinga diagnostic yi-4.5% -Wuhan kulindeleke ukuba ukongeza malunga amatyala 1000 iqinisekisiwe. 2020-01-27. http://bj.people.com.cn/n2/2020/0127/c14540-33745973.html.

[4] Times Global. Chaoliang UJiang, uNobhala weKomiti Party lephondo: Zonke izigulane arhanelelekayo e Wuhan iye yavavanywa iintsuku ezimbini. Jan 9 th , 2020 https://mbd.baidu.com/news-page/data/landingshare? pageType = 1 & isBdboxFrom = 1 & nemeko =% 7B% 22nid% 22% 3A% 22 iindaba _ 10556299211611717315% 22% 2C% 22source Ukusuka% 22% 3A% 22bjh% 22% 7D.

[5] Office General of Health Commission yeSizwe ye-Peoples Republic of China, Office General of Administration State of Traditional Chinese Medicine. Isaziso ngokuphathelele kunikezelo i <Protocol for the Ugonyo Nonyango yinyumoniya kunye Inoveli Coronavirus Usulelo> (Trial Version 5). 2020-02-05, http: // www.nhc.gov.cn/yzygj/s7653p.

[6] Kaitao Yao, Mingyu Liu, xin Li et al. Uhlalutyo emva lwezonyango Unyango yinyumoniya abosulelwe-Coronavirus Inoveli kunye Chinese Traditional Medicine Lianhuaqingwen. Chinese Journal of wokulinga Pharmaceutics, 2020-02-06, http://doi.org/10.13422/j.cnki.syfjx.20201099.

[7] Office General of Health Commission yeSizwe ye-Peoples Republic of China, Office General of Administration State of Traditional Chinese Medicine. Isaziso ngokuphathelele kunikezelo i <Protocol for the Ugonyo Nonyango yinyumoniya kunye Inoveli Coronavirus Usulelo> (Trial Version 4) 2020-1-27, http: // www.nhc.gov.cn/yzygj/s7653p.

[8] Health Commission ka-Peoples Republic of Wuhan. Isiphakamiso ukuvimbela ekhaya-based yinyumoniya losulelo Inoveli coronavirus amayeza yaseTshayina ikhutshwe Wuhan City. http://wjw.wuhan.gov.cn/front/web/showDetail/2020020109319,2020-02-01.

[9] uJiang Yi, Runming Jin, Yuejie Zheng, et al. nokuvumelana elinobungcungela sifo, unyango kunye nothintelo lwe uhlobo olutsha lwe losulelo coronavirus ebantwaneni. (Version 1) [J]. IPediatrics Chinese Practical Clinical Journal, 2020, 35 (2): 8185.

[10] DROSTEN C, Gunther S, PREISER W, et al. Ukuchongwa a coronavirus inoveli xa izigulane yondele kakhulu syndrome yokuphefumla [J]. N Engl J Med, 2003, 348 (20): 1967-1976. Doi: 10. 1056 / NEJMoa 030747.

[11] KILLERBY ME, Biggs HM, MIDGLEY CM, et al. Middle East kungaPhefumli syndrome iProtokholi [J]. Yesevisi ziphatha Dis, 2020, 26 (2): 191-198. Doi: 10,3201 / eid2602. 190697.

[12] WU, F, zhao, S, YU, B. et al. A coronavirus ezintsha ezinxulumene nesifo yokuphefumla abangabantu China [J]. Nature, 2020-02-03. Doi: 10. 1038 / s41586-020-2008-3 (2020).

[13] zhou P, YANG XL, wang XG, et al. Nesifo inyumoniya ezinxulumene ne coronavirus entsha bat imvelaphi mhlawumbi [J]. ngokwemvelo, 2020-02-03. Doi: 1038 / s41586-020-2012-7.

Finance Sina [14]. isithsaba Inoveli inyumoniya ikiti yavunywa ngokusesikweni moshilongo esibhedlele

Isithuba kulindeleke ukuba ngu- iiyure ezi-2, 2020-01-27. http://finance.sina.com.cn/wm/2020-01-27/doc iihnzahk6611465.shtml.

[15] Chinese News Network. Isiqinisekiso lweemeko ezikrokrelekayo iye okukhawulezileyo kunye nesakhono ekufumanekeni nucleic acid imihla waye waphucuka kwiPhondo Hubei, 2020-02-07. https://mbd.baidu.com/newspage/data/landingshare? 1pageType = 1 & isBdboxFrom = 1 & nemeko =% 7B% 22nid% 22% 3A% 22news-9465728434148816188% 22% 7D.

[16] Zhenhua Jia, YiLing Wu. Theory of izifo collateral lokukhokela ukufunda kwezifo zangaphandle febrile [J]. Global Chinese Medicine, 2010,3 (01): 26-28.

[17] YiLing Wu. Theory of Qi kunye collaterals [M]. Beijing: Science and Literature Technology Press, 20018: 1327-1329.

[18] Shunya Zhu, Xiaoying Li, Yunling Wei, et al. zomthetho ezintathu Chinese iyeza kwisigaba SARS Preliminary uphando malunga inhibition of coronavirus in vitro [J]. Biotechnology Communications, 2003,14 (5): 390-392.

[19] Hongying Mo, Changwen Ke, Jinping Zheng, et al. Lianhuaqingwen njengezingxobo Anti-A in vitro

Wokulinga Isifundo Type A Influenza Virus [J]. New Chinese Medicine and Clinical Pharmacology, 2007,18 (1): 69.

[20] ding yw, Zeng LJ, li RF, et al. Imithi Chinese lianhuaqingwen philisi usebenzisa umsebenzi anti-influenza ngokusebenzisa inhibition of zityalwe wentsholongwane egazini kunye neempembelelo umsebenzi omzimba [J]. BMC zincedisana Altern Ned, 2017, 17 (1): 130. Doi: 10,1186 / s12906-017-1585-7.

[21] Duan ZP, jia zh, Zhang J, et al. amayeza Natural herbal Lianhuaqingwen capsule anti-komkhuhlane A (H1N1) kwetyala: arandomized, iimfama kabini, olawulwa ulingo lwezonyango HIV [J]. Chinese Nedical Journal, 2011, 124 (18): 2925-2933.

[22] Gengxin Liu, Yanxia Zhang, Jiqing Yang, et al. Lianhuaqingwen philisi for the Treatment of A H1N1 lulingo ukufunda lwezonyango [J]. Journal of Diseases Ezinzima, 2010, 9 (1): 1416.

(Umhla wokufunyanwa: 2020-02-09; Umhla uhlaziyo: 2020-02-10)

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