Clinical Ukusebenza Uhlalutyo nge 54 Amatyala NCP kunye Unyango Lianhuaqingwen Granules Cheng Dezhong, Li Yi

(The Puren ezingamalungu Hospital of Wuhan University of Science and Technology, Wuhan 430081, China)

Abstract Injongo : Ukuze hlalutya impumelelo bezonyango Lianhua Qingwen Granules (LH-C) on inoveli coronavirus pneumonia (NCP) izigulane. Iindlela : Idatha kwezonyango 54 NCP Izigulane eziqhelekileyo emva zahlalutywa kwi-Puren nakwiikomiti Hospital ku Wuhan University of Science and Technology. iziphumo: Emva unyango kunye LH-C iintsuku ezintathu zilandelelana. Izinga iimpawu yokuduka e ifiva, asthenia kunye ukhohlokhohlo yaba 47,5%, 35.1%, kwaye 20,0%, ngokulandelelana. Kweentsuku ezintlanu, izinga iimpawu yokuduka e ifiva, asthenia kunye ukhohlokhohlo lanyuka 62,5%, 59,5%, kunye 50.0%, ngokulandelelana. Ngosuku lwesixhenxe, izinga iimpawu yokuduka e ifiva, asthenia kunye ukhohlokhohlo wafikelela kwi 80.0%, 75.7%, kunye 76.7%. Iintsuku iimpawu yokuduka e ifiva, asthenia, kunye ukhohlokhohlo waba 3.6 ± 2.14 iintsuku, 4.1 ± 2,58 iintsuku, kwaye 5.3 ± 2,63 iintsuku. Malungana ezinye iimpawu zanyamalala kwi stuffiness esifubeni, lo dyspnea, kwaye crackles emanzi yaba 84,6%, i-100%, kwaye 89,5%; kunye nokusebenza iyonke yaba ukuya kwi 81,6%, ngaphandle naziphi na iziphumo ebezingalindelekanga zaphawula yi ngomhla wesixhenxe. Isiphelo : LH-C inokulunciphisa kakhulu iimpawu lwezonyango ngayo izigulane zesiqhelo NCP ngokuthi ziyibuyisela umkhuhlane, asthenia, ukhukho, nokucutha nexesha labo. Zonke ezi ziphumo banike ubungqina lokuqala lwezonyango ze LH-C kule unyango NCP.

Amagama angundoqo: Lianhuaqingwen; SARS-selwe-2; NCP; ukusebenza Clinical; Uhlalutyo emva; amatyala gumbini

Inombolo uhlobo Chinese: R254.3; R256.19; R512.99

Uxwebhu Ikhowudi yesazisi: A doi: 10. 3969 / j. Issn. 1673-7202. 2020. 02. 006

Kutshanje, lo coronavirus inyumoniya inoveli (iNovel Coronavirus inyumoniya, NCP) ubhubhane sele onabileyo, kwaye zihlelwa Class B kwezifo ezosulelayo (ilawulwe isifo Class A) [1] . Kumazwe angaphezu kwama-20 kunye neziphaluka ehlabathini ziye ingxelo ukuqinisekisile amacala, yaye iya isiba isiganeko lwempilo yoluntu jikelele [2] . Iimpawu eziphambili NCP zezi ifiva, asthenia kunye ukhohlokhohlo owomileyo. A zimbalwa izigulana uneempawu ezifana isithintelo ngeempumlo, impumlo esihambisayo, umqala obuhlungu kunye norhudo. Kuvakala ukuba 15.7% ezigulane NCP zilaliswe esibhedlele, kwaye izinga lokusweleka yinto malunga 1.4% [3] . Ezinye izifundo akwabonisa ukuba-26% ye izigulana kufuneka unyango kwicandelo labagula kakhulu, kwaye izinga lokufa izigulana kuqinisekiswa yi 4.3% [4] , zila unyango, isiphumo therapeutic kuyingozi kakhulu. Noko ke, ukuza kuthi ga ngoku, akukho amayeza olusebenzayo antiviral for NCP, kodwa uphawu-based isetyenziswe therapiesare ikakhulu. Sisebenzise Lianhuaqingwen Granule edibene nonyango ucwangciso ukunyanga esi sifo yaye nemiphumo emihle. Ngoko ke, thina apha ingxelo uhlalutyo emva kwiinkcukacha kwezonyango 54 izigulane NCP esibhedlele sethu, ukwenzela ukuphucula umgangatho unyango kwesi sifo.

  1. 1.        Data kunye neendlela

1.1.       Data jikelele kuko Uphando na amatyala 54 inoveli coronavirus pneumonia leyo ziphathwa Lianhuaqingwen Granules kudityaniswe unyango eqhelekileyo (ngokutsho yokucupha izifo, enika inkxaso okunesondlo, unyango antiviral kunye nonyango antibacterial) ukususela ngoJanuwari 1-31, 2020 kwiSibhedlele Puren amanyene Wuhan University of Science and Technology. Iminyaka yobudala umyinge iziguli 60,1 ± 16,98 iminyaka, iquka 29 eyindoda (53.7%) kunye 25 ababhinqileyo (46.3%); iqondo lobushushu emzimbeni engumndilili (37.93 ± 0.93) ℃, iqondo lobushushu emzimbeni udibaniso yaba 38,05 ℃, kwaye ubushushu bomzimba ubuninzi phambi kokuba uthole (38.54) ± 0.60) ℃; avareji izinga intliziyo 87,9 ± 11,80 ibetha / min, izinga intliziyo udibaniso yaba 85.5 ibetha / min, umlinganiselo esiphezulu kwaba 112 ibetha / min; lo internal engumndilili 21.1 ± 3,78 phefumla / min, udibaniso kwakufa 20,0 phefumla / min, umlinganiselo esiphezulu kwaba 30,0 Ukuphefumla / min; abo imbali lwegazi yaba amatyala-21 (38.9%), kunye nabo ngembali nesifo sentliziyo yaba amatyala-7 (13%). Kukho iimeko 10 seswekile sinwenwa (18.5%), iimeko 10 iposi yobuchopho (18.5%) nabo. Luhlolo elebhu: amatyala 31 (64.6%) ze leucocytes kumqolo eqhelekileyo, amatyala 9 (18.8%) alithe gangqa ixabiso eziqhelekileyo, amatyala-8 (16.7%) ngaphezulu kwe ixabiso eqhelekileyo; Amatyala 25 (52.1%) ze neutrophils kumqolo eqhelekileyo, amatyala-23 (47.9%) ebengaphezulu ixabiso eziqhelekileyo, iimeko ezili-14 (29.2%) kweli uluhlu oluqhelekileyo, amatyala 34 (70.8%) engaphantsi lingaphezulu kunexabiso eziqhelekileyo ; zonke izigulane waba amanqanaba iiproteins C-izidubuli ngaphezulu kunesiqhelo. Zonke izigulane ziphathwa Lianhuaqingwen Granules ukuba umlinganiselo 8.0 ± 4.10 iintsuku, kunye udibaniso iintsuku 7.0, ubuncinane iintsuku 1.0 kunye ubuninzi iintsuku 16.0.

Table 1 Inkcazelo ngokuthe gabalala of NCP Izigulane

into

amatyala

(Count)

Isiphumo

Project

amatyala

(Count)

Isiphumo

Age

54

60,10 ± 16,98

iiseli Mesenchymal (%)

Man (%)

29

53,7

eqhelekileyo

25

52,1

lobushushu emzimbeni

54

37,93 ± 0,93

low

0

0.0

Heart Rate (ibetha / min)

54

87,90 ± 11,80

high

23

47,9

uphefumlele (Ukuphefumla / min)

54

21.10 ± 3,78

Le lymphocyte (%)

imbali Medical

eqhelekileyo

14

29.2

Igazi elonyukayo

21

38.9

low

34

70,8

isifo sentliziyo

7

13

high

0

0.0

Iswekile yemellitus

10

18.5

C-izidubuli protein (%)

iqhosha Cerebral

10

18.5

eqhelekileyo

0

0.0

Iiseli zegazi ezimhlophe (%)

low

0

0.0

eqhelekileyo

31

64,6

high

44

100.0

low

9

18.8

Iintsuku kunye nonyango lwe Lianhuaqingwen Granules

54

8.0 ± 4.10

high

8

16.7

1.2.       Iinqobo zokuChonga Izigulane ziye une NCP HIV xa iikhrayitheriya diagnostic ezintsha usulelo coronavirus (trial version wesihlanu) [5] , waza wabonisa iziphumo ezihle kunye uvavanyo nucleic awayekwenzele isikhohlela, swab emqaleni kuthoba netuwa phecana sokuphefumla.

1.3.       Iikhrayitheriya Ukubandakanywa I eliqhelekileyo [5] e-izigulane angaphezulu-18 leminyaka ubudala kunye kumhlangabeza NCP iikhrayitheriya diagnostic.

1.4.       Criteria Ukuthintelwa 1) Severe nezibalulekileyo izigulane NCP; 2) naziphi na ezinye izifo ezingapheliyo zemiphunga, izifo zemiphunga iintsholongwane ezifana tonsils suppurative, etsolo tracheobronchial iphika, sinusitis, otitis media kunye nezinye izifo zemiphunga ezichaphazela uvavanyo yocwaningo lwezempilo; 3) ne immunodeficiency kakhulu lokuqala, isifo immunodeficiency syndrome, naso sokuphefumla malformation naso isifo sentliziyo, dysplasia yemiphunga kunye nezinye izifo ezingundoqo.

1.5.       Unyango Lianhuaqingwen Granule sathathwa ngomlomo, 1 ibhegi / ixesha, 3times / d (eBeijing YiLing, gyzz20100040.); Amachiza eziphambili zonyango baba naliti efakwa of immunoglobulin yabantu (Guizhou Taibang Biological Products Co., Ltd., GJZ s20023034) 2.5g, kanye ngemini; Inaliti ganciclovir (Hubei Keyi Pharmaceutical Co., Ltd., GJZ h10980188) 0.5g, kanye ngemini; Levofloxacin Hydrochloride Inaliti (Hu Hu Nanwuzhoutong Pharmaceutical Co., Ltd., gjzz h20083916) 0.4g, kanye ngemini; Methylprednisolone Sodium Succinate ukuba isitofu (Liaoning hisico Pharmaceutical Co., Ltd., gjzz h20133234) 40mg, kanye ngemini.

1.6.       Index Uqwalaselo Idatha kwezonyango 54 izigulane NCP aye ahlalutywa, kuquka umlinganiselo yokuduka iimpawu eziphambili (ifiva, asthenia, ukhohlokhohlo) emva kwe-3, 5, iintsuku ezisi-7, imihla yokuduka umkhuhlane kunye nezinye iimpawu kunye neempawu.

1.7.       Iinqobo zokugweba zokuhlola ukusebenza Iimpawu eziphambili "hayi" sithathwa 0 ngongoma, yaye "ewe" njengendawo yesiqalo 1. (phambi kokuba unyango - emva konyango) / phambi kokuba kunyango uphawu score izinga unciphiso, xa score ngaphezu kwama-30%, oko kuthathwa njenge unyango olusebenzayo, xa score ngaphantsi kwama-30%, oko kuthathwa njenge unyango ubhalwe, xa i score ngaphezu kwama-30%, oko kuthathwa njenge unyango / lilonke inani olusebenzayo amatyala emva kokuba unyango njengoko ngempumelelo unyango olusebenzayo, nokusebenza unyango zonke izigulane emva 3, 5 no-7 iintsuku unyango kuhlalutywa.

1.8.       Indlela Statistical Olu phando isebenzisa SAS 9.4 software ukwenzela uhlalutyo oluneenkcukacha, idatha ukubala ichazwa inani lamatyala kunye nomlinganiselo composition, iinkcukacha wemilinganiso ichazwa kuphambuka koko ± standard okanye median, kwaye idata lokwandlalela kunye nezalathiso ukusebenza abakwindawo yotyelelo ngalinye zichaziwe kwaye zihlalutywe.

  1. 2.        Isiphumo

2.1.       Izinga Ukunyamalala iimpawu eziphambili (ifiva, asthenia, ukhohlokhohlo) 1) Phambi kokuba unyango, kukho amatyala 40 fever (74.1%), iimeko 37 asthenia (68.5%), amatyala 30 ukhohlokhohlo (55.6%) nabo; 2) Emva kweentsuku 3 unyango, kukho izihlandlo ezili-19 fever (47.5%), amatyala ayi-13 ka asthenia (35.1%), iimeko ezi-6 ze ukhohlokhohlo (20.0%) nabo; 3) Emva kweentsuku ezi-5 unyango, waphila qete kwiimeko-25 (62.5%), asthenia kwiimeko 22 (59.5%), ukhohlokhohlo kwiimeko-15 (50.0%); 4) Emva kweentsuku 7 unyango, waphila qete kwiimeko-32 (80.0%), asthenia kwiimeko-28 (75.0%) Iimpawu ukhohlokhohlo unyamalale kwiimeko-23 (76.7%). Jonga Uluhlu 2 kunye kuMfanekiso 1.

 

 

Izinga iTheyibhile 2 Ukunyamalala iimpawu eziphambili izigulane NCP (%)

Project

Case Inani Ngaphambi unyango

amatyala ezehlisiwe emva unyango 3d

amatyala ezehlisiwe emva unyango 5d

amatyala ezehlisiwe emva unyango 7d

Fever (n = 54)

40 (74.1)

19 (47.5)

25 (62.5)

32 (80)

Asthenia (n = 54)

37 (68.5)

13 (35.1)

22 (59.5)

28 (75.7)

Ukhohlokhohlo (n = 54)

30 (55.6)

6 (20.0)

15 (50.0)

23 (76.7)

2.2.      
Main symptoms (fever, asthenia, cough) disappeared time 1) The average disappearance time of fever symptoms was (3.6 ± 2.14) days, median disappearance time was 3.0 days, with the shortest time as 1.0 days and the longest time as 8.0 days; 2) the average disappearance time of asthenia symptoms were (4.1 ± 2.58) days, median disappearance time were 4.0 days, the shortest 1.0 days, the longest 12.0 days; 3) the average disappearance of cough symptoms days (5.3 ± 2.63) d, median disappearing days (5.0 d), minimum disappearing days (1.0 d), maximum disappearing days (12.0 d).

71
Figure rate 1 Ukunyamalala iimpawu eziphambili kwizigulane NCP

81

Figure izinga 2 Ukunyamalala ezinye iimpawu kunye nemiqondiso izigulane NCP

85

Figure 3 Treatment ukusebenza kwizigulane NCP

2.3.       Izinga Ukunyamalala ezinye iimpawu kunye nemiqondiso 1) Phambi unyango: amatyala ayi-13 (24.1%) isifuba lokubandezeleka, amatyala-8 (14.8%) bakhe dyspnea, amatyala-10 (18.5%) ukuba ukudla, 19 amatyala (35.2%), waba rales efumileyo ; 2) kwiintsuku ezisi-7 emva kokuba unyango: amatyala 2 isifuba lokubandezeleka, ngamatyala 11 (84.6%) yaphela, 0 amatyala dyspnea, namatyala 8 wanyamalala. Kukho iimeko 6 uneanorexia ezo, kunye amatyala 4 odisappeared (40.0%), iimeko ezi-2 rales efumileyo, ngamatyala 17 wanyamalala (89.5%). Jonga Uluhlu 3 Umfanekiso wesi-2.

Table izinga 3 Ukunyamalala ezinye iimpawu kunye nemiqondiso izigulane NCP (%)

Project

inombolo Case Ngaphambi Treatment

Case Ukunciphisa Emva unyango

Chest Ekubandezelekeni (n = 54)

13 (24.1)

11 (84.6)

Dyspnea (n = 54)

8 (14.8)

8 (100.0)

Anorexia (n = 54)

10 (18.5)

4 (40.0)

rales emanzi (n = 54)

19 (35.2)

17 (89.5)

2.4.       Ukusebenza Unyango iintsuku ezintathu emva konyango, 23 ka-54 izigulane NCP baba olusebenzayo (46.9%); kwiintsuku ezintlanu emva konyango, 34 olusebenzayo (69.4%); iintsuku ezisixhenxe emva konyango, 40 olusebenzayo (81.6%). Jonga Uluhlu 4 Isazobe 3.

Uluhlu 4 Izinga ngempumelelo NCP bande izigulane [amatyala (%)]

Project

3d emva konyango

5d emva konyango

7d emva konyango

Ephumelelayo (n = 54)

23 (46.9)

34 (69.4)

40 (81.6)

Zamazwi (n = 54)

26 (53.1)

15 (30.6)

9 (18.4)

 

2.5.       Uhlalutyo Ukhuseleko Emva uhlalutyo, akukho okubi ezicaceleyo uvavanyo yesiqhelo igazi, isibindi kunye kidney umsebenzi test ekuhambeni Lianhuaqingwen Granule edibene nonyango lwesiqhelo. Xa kuthelekiswa unyango previos, zonke izigulane ngaphandle kokuba iimpawu yokuqala phecana yokuphefumla kunye wokugaya abazange kuvela iimpawu nobunzima entsha okanye iimpawu mandundu, nto leyo ebonisa ukuba Lianhuaqingwen Granule ikhuselekile isicelo clinical.

3.        Xoxa

Ngokutsho uphando, coronaviruses ezifunyaniswe abantu isasazwa ngokubanzi kuyo abantu kunye nezinye izilwanyana ezanyisayo, abanye abantu baye uneempawu eziphakathi emva kokuba wosulelwe coronavirus, kodwa abanye abantu uneempawu obukhulu ngisho death.During Kwiminyaka engama-20 edlulileyo, ethandwayo β-coronaviruses babini ezimandundu ezihlasela zosulele ngokuphefumla Syndrome Virus (SARS-selwe) kunye Middle East kungaPhefumli syndrome (zezi--selwe), ukufa abangenwa-10% ne-37% ngokulandelelana. Nangona kunjalo, le coronavirus ezifunyaniswe abantu kuphela isesisiqalo. Kusenokwenzeka ukuba izifo ezininzi zoonotic kunye coronaviruses ezosulela kakhulu aza kuyifumana kwixesha elizayo [6] . Le ubhubhane kudalwe yi-SARS-selwe-2 [7] , nto leyo HIV-Strand zigutyungelwe β-coronavirus olunye-Strand RNA, ukuba kumgangatho ophezulu ulandelelwano ukufana kunye enzyme ka-SARS kunye zezi-. Ukongeza, uhlalutyo lwesakhiwo protein ibonisa ukuba yokubopha "pocket" ka-SARS-selwe-2, SARS kunye zezi- enzayim ntsholongwane, amachiza ngendeb ', ngoko ke ucingela ukuba anti-SARS kunye zezi- neziyobisi zangaphambili ungasetyenziswa kunyango NCP [8] .

Kutshanje, uhlalutyo kwezonyango 1,099 izigulane NCP kumaphondo 31 nezixeko ingxelo ukuba inani ebanjwe yicesina ukhohlokhohlo kubaguli esibhedlele yaba 87,9% kunye 67,7% [3] , yaye enye 138 izigulane NCP Uphando lwezonyango lufumanise ukuba iimpawu eziphambili clinical ziquka fever (98.6%), asthenia (69.6%), ukhohlokhohlo (59.4%), izinga lokusweleka yi 4.3% [4] , kunye nengxelo izigulane 12 ingxelo yokuba iimpawu eziphambili zezi ukhohlokhohlo (46.3%), zangentla ezihlasela zosulele ngokuphefumla elithi ingxinano (61.5%), myalgia (23.1%) kunye nentloko (23.1%) [9] . "Diagnosis and Treatment Programme for Inoveli Coronavirus inyumoniya (Trial Fifth Edition) [5] ekhutshwe yiKomishoni yezeMpilo yeSizwe" ithi esi sifo iimpawu eziphambili zezi nangecesina, asthenia, kunye ukhohlokhohlo. Ukuza kuthi ga ngoku, akukho iziyobisi asiphumeleli antiviral aphathe NCIP, uphawu-based nokusebenzisa inkxaso kunye nokungenelela olubanzi zisetyenziswa okwangoku yi ekliniki. Ngoko ke, unyango ukuphucula iimpawu zonyango, ezifana ifiva, asthenia, kunye ukhohlokhohlo enxulumene sifo, ziyakubaluleka lwezonyango kakhulu ekunciphiseni ubuzaza kwesifo kunye nokwehlisa ixesha sifo.

Isiseko and Clinical Ulingo phambili Lianhuaqingwen philisi (Granules) lubonise ukuba LH-C kungadala zinqanda i-SARS-selwe viruse exsiting in vitro inkcubeko iiseli, kwaye neziphumo ezibalulekileyo inhibitory kwi H1N1, H3N2, H7N9 influenza virus njalo [ 11-12] , kwaye akukho mahluko kunye Oseltamivir Phosphate ukuba ekunciphiseni ixesha nucleic acid egazini H1N1 izigulane influenza ukuyitshintsha elibi kunye nexesha zonke iimpawu yomkhuhlane, kwaye esasixolelwe nangecesina, nokuphelisa khohlo, eyethisa kwezihlunu, asthenia kunye nezinye iimpawu [ 13,14] , ngenxa yoko, i-data kwezonyango indibanisela Lianhua Qingwen Granules ukuba unyango lwezigulane NCP eqhelekileyo ukususela ngoJanuwari 1 ukuya 30, 2020 kwaza kushwankathelwe zihlalutywe kwi amandla ngcono kwi ifiva, asthenia, ukhohlokhohlo kunye nezinye iimpawu umva. Kubonakele ukuba phantsi isiseko unyango lwesiqhelo, ukuhlanganiswa Lianhuaqingwen Granule iintsuku ezi-3, icesina wanyamalala rate yi 47,5%; emva ekunyangeni iintsuku ezi-5, ifiva, asthenia kunye ukhohlokhohlo rates Ukunyamalala ezi 62,5%, 59,5%, kunye 50.0%; emva ekunyangeni iintsuku ezisi-7, ifiva, irhafu Ukunyamalala asthenia, kunye ukhohlokhohlo ezi 80.0%, 75.7%, kunye 76.7% ngokulandelelana. Ithuba anyamalale avareji imihla 3.6, iintsuku 4.1, kunye neentsuku 5.3, nto leyo ebonisa ukuba Lianhuaqingwen philisi nokuphelisa kakhulu iimpawu eziphambili ifiva, asthenia, kunye khohlo, kwaye kananjalo nesiphumo ukuphucuka obonakalayo kothula esifubeni yengxinano, dyspnea, kunye rales emanzi of lung, izinga olusebenzayo yi 81,6%. Oku kubonisa ukuba chiza nemiphumo emihle lwezonyango ekuphuculeni iimpawu lwezonyango, ekunciphiseni ubungqongqo sifo, kwaye ukunciphisa ixesha lokuhlala esibhedlele. Ngakumbi uhlaziye idatha lwezonyango, phakathi izigulane kwafunyaniswa NCP uhlobo eqhelekileyo, ityala esiveza watyunjwa kwaye ishwankathelwe ngolu hlobo lulandelayo ukuze zinike izimvo zonyango ngenxa yonyango sifo.

A obhinqileyo, iminyaka 48 ubudala, inzalelwane Hubei, akukho enye imbali izifo. NgoJanuwari 11, 2020, iimpawu eziphambili baba nangecesina, khohlo, isikhohlela, umqala obuhlungu, impumlo esihambisayo, eyethisa umzimba, ukutswina, bamba umphefumlo. Ngelo esibhedlele, uvavanyo esifubeni, esifubeni bhanyabhanya kunye CT emiphungeni ndacebisa isifo semiphunga. Emva ngokubaphatha Ganciclovir (isitofu efakwa, 0.5g, 1 kwexesha / ngosuku) kunye oseltamivir (ezomlomo, 1 Isingxobo, amaxesha 2 / ngosuku), nomkhuhlane ngokuphindaphindiweyo. CT of imiphunga ngoJanuwari 17 wabonisa "usuleleko mazwe-lung, inyumoniya wegciwane". NgoJanuwari 18, yena wangeniswa kwisibhedlele with "usuleleko yemiphunga", ukuxilongwa ngokwasemzimbeni: iqondo lobushushu emzimbeni 39.3 ℃, izinga intliziyo 112 ibetha / min, uphefumlele 25 phefumla / min, uxinzelelo lwegazi 130/70 mm HG (1 mm HG = 0,133 kPa), umqala ebomvu, zamafu izandi umphunga, eyomileyo esichitha-chithwe kunye rales ufumile. Blood uviwo wesiqhelo: igazi emhlophe cell count 3,53 × 10 9/ L, neutrophil umlinganiselo 67.2%, lymphocyte ratio 28.4%. Blood uviwo ezinto: ALT: 35.3 U / L, AST: 42.6U / L, albumin 35.0g / L, zincancise dehydrogenase 370 U / L, hydroxybutyrate dehydrogenase 275 U / L, NCP nucleic uvavanyo asidi kwabonisa positive.

(1)
Umfanekiso 4: Chest CT iziphumo

 

Emva ukungena, wasuka wanikwa levofloxacin (isitofu efakwa, 0.4 g, 1 xesha / umhla), ivithamin C (isitofu efakwa, 3G, 1 xesha / umhla), ambroxol (inaliti efakwa, 30mg, amaxesha 2 / ngosuku), Yanhuning (efakwa inaliti, 0.4 g, 1 xesha / umhla), methylprednisolone (inaliti efakwa, 40 mg, 1 kwexesha / ngosuku). NgoJanuwari 21, esifubeni CT wabonisa "izilonda ezosulelayo kuzo zombini imiphunga, xa kuthelekiswa inkqubela elidlulileyo (2020.01.17), amabini pleural ziyatyeba". Ukulungisa isicwangciso sonyango, idosi moxifloxacin (isitofu efakwa, 0.4 g, 1 kwexesha / d), ganciclovir (inaliti efakwa, 0.5 g, 1 kwexesha / d), idosi Lianhua Qingwen Granules (ezomlomo, 1 ibhegi, amaxesha 3 / d), i lobushushu emzimbeni aphenduke eqhelekileyo ngosuku olulandelayo. NgoJanuwari 28 ngoJanuwari 31, Uvavanyo NCP yaba elibi, yaye Feberuary 01, isigulane kungekho ifiva, khohlo, isikhohlela, zamafu izandi ukuphefumla omabini imiphunga, elomileyo ezimbalwa kunye rales efumileyo, kunye nesifuba CT wabonisa absorbination yi ngakumbi zicace kunangaphambili, njengoko kubonisiwe kwiSazobe 4, routine igazi kunye neemviwo ngamachiza negazi eziqhelekileyo, yaye NCPS abangenayo amaxesha 2 ezilandelelanayo, zingqinelana nomgangatho ichiza lwezonyango. Bona agxothwa esibhedlele kunye nempilo iibhokisi 2 Lianhua Qingwen granules ekhaya (ezomlomo, 1 ibhegi, amaxesha 3 / d). Isigulane kumnandi emva olulandelayo-up kude kunjalo, akukho ifiva, ukukhohlela, yesikhohlela kunye nezinye iimpawu.

Kwiimeko ezithile zikhankanywe ngentla-, ubushushu bomzimba babuyela eqhelekileyo ngosuku olulandelayo emva kokuba isicelo odityanisiweyo we Lianhuaqingwen Granules, kwaye iimpawu kunye neempawu ezifana ukhohlokhohlo kwaye ufumile rales zaye zaphucuka kakhulu, nto leyo iyavumelana ziyindlela kunye iziphumo emva Uhlalutyo clinical iimeko 54, ebonisa iingenelo uphawu iyeza Chinese compound "ummiselo jikelele kunye nonyango multi-ekujoliswe", nto leyo ebonisa ukuba Lianhuaqingwen Granules ine isicelo lwezonyango ebalulekileyo unyango izigulane NCP. Ukongeza, kufuneka wabonisa ukuba olu phando isifundo lwezonyango emva for NCP kwafunyaniswa ukuba izigulane bande, ubukhulu sampuli encinane, abasweli yothelekiso ukusebenza kwiqela lolawulo, ezinye izigulane basilela ukwenza iimviwo esifubeni umfanekiso ngexesha , kwaye ke iimfuno nokusebenza yezonyango ngqo ukuba bavandlakanywe zii sample enkulu, kuba, olungenamkhethe olulawulwayo isifundo clinical.

Ukukhabana kwemidla: Bonke ababhali bavakalisa ukuba akukho conflict of interest.

Reference:

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[2] World Health Organization. 2019 inoveli ubhubhane Coronavirus Regulations Health International (2005) "Inkcazo kweNtlanganiso Second weKomiti Emergency [EB / OL]. (2020- 01-30) [2020-02-17]. Https://www.who.Int/zh/news-room/.

[3] Weijie G, Zhangyi N. Yu H.et al. charateristics Clinival ka 2019 inoveli corpnavirus inection e China [J / Ndikhoyo] MedRxiv, Posted Februwari, 09, 2020.http: //dx.doi.org/10.1101/2020.02.06.20020974.

[4] eDawei W, Bo H, Chang H, et al. Iimpawu kwezonyango 138 esibhedlele Izigulane 2019 Inoveli Corpnavirus-aboSulelwe inyumoniya e Wuhan, China [J / Ndikhoyo] .JAMA Ipapashwe online Februwari 7, 2020 https://jamanetwork.com/journals/jama/article-abstract/2761044.

[5] Ofisi Jikelele yeKomishoni yezeMpilo yeSizwe kunye ofisi Ulawulo State of Traditional Chinese Medicine. Isaziso on Ukuprintwa Ukukhupha diagnosis and Treatment Programme for Inoveli Coronavirus inyumoniya (Trial Fifth Edition) [EB / OL]. (2020-02-05) [2020-02-17]. http://www.nhc.gov.cn/yzygj/s7653p.

[6] Chaolin H, Yeming W, Xingwang L, et al. iimpawu kwezonyango izigulane abasuleleke 2019 corpnavirus inoveli e Wuhan, China [J]. Lancet: January 24, 2020: 1-9.

[7] World Health Organization. ulawulo lwezonyango obukhulu usulelo yondele resporatory xa usuleleko Inoveli Coronavirus (nCoV) kurhanelwa: Interim Guidence [EB / OL]. (2020-02-03) [2020-02-17]. https: //www.who.int/zh/news-room/detail/30-01-2020-statement-on-the yesibini-mmeting-of-the-ngamazwe-impilo-imimiselo (2015) Emergency-commottee -regarding-i-kokuqhambuka-of-inoveli-corpnavirus- (2019-ncov), 2020-01-12 / 2020-02-03.

[8] iinketho Guangdi L Erik D C. zonyango ukuze 2019 Inoveli Coronavirus (nCoV) [J / Ndikhoyo] Nature Reviews Drug Discovery, 2020-02-10. https: // www. Nature.com/articles/d41573-020-00016-0.

[9] De C Minggui L, Lai W, et al. Nokwanda kunye istics Character lwezonyango lweNTSHOLONGWANE Inoveli Coronavirus Ukubandakanya 13 Izigulane Out [J / OL] esilondeni. Ipapashwe online Februwari 7, 2020 https: //jamanet-work.com/journals/jama/fullarticle/2761043.

[10] Zhu Shunya, Li Xiaoying, Wei Yunling, et al. uphononongo lokuqala kwi in vitro isiphumo inhibitory of nemigqaliselo amayeza Chinese emveli ezintathu coronavirus SARS-ezinxulumene [J]. Journal of Biotechnology, 2003, 14 (5): 390-392.

[11] Mo Hongzhang, Ke Changwen, Zheng Jinping, et al. ukufunda yolwazi Lianhua Qingwen njengezingxobo zokulwa umkhuhlane A ntsholongwane in vitro [j]. New Drug of Traditional Chinese Medicine and Clinical Pharmacology, 2007, 18 (1): 6-9.

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