Clinical hlokomela ea 63 belaelloang Cases tsa bukeng Coronavirus serame sa matšoafo a Tšoara ka Traditional Chinese Medicine Lianhuaqingwen capsules

Ruibing lv, wenju Wang, Xin Li

CR & WISCO General Hospital ea Wuhan University ea Saense le Technology, 209 metallurgical mokhoa, Qingshan setereke, Wuhan 430080, profensing ea Hubei, China

[Bonahaleng] O bjective: Retrospectively hlahloba ea litleleniki bohlokwa ba tsamaiso ea Lianhuaqingwen ho phekola Maemong a belaela tsa lipale serame sa matšoafo coronavirus. Mokhoa bokella 101bakuli ba ile belaela Maemong a le o ile a lumela ho CR & WISCO General Hospital ea Wuhan University ea Saense le Technology le ile belaela ea pokano ka litekanyetso le tekotshupo bakeng sa e ncha coronavirus serame sa matšoafo tloha Jan 1 , th ho Jan 27 , th . Har'a 101 bakuli, 63Maemong a ka sehlopha se kalafo ba ne ba tšoaroa ka motsoako oa phekolo tloaelehileng (tšehetso phekolo phepo e nepahetseng, phekolo bontshang matshwao, antiviral le loantsang likokoana phekolo), noa ea setso Chinese moriana Lianhuaqingwen capsules. Ka sehlopha taolo, 38Maemong a ne feela fuwa kalafo tloaelehileng. Ya data Clinical ne bokella ka mor'a 10matsatsi a ya kalafo, 'me matšoao a ka sehloohong (feberu le khohlela) tsa Lihlopha tseo tse peli li ne li bapisoa, nyamele sekhahla, bolelele ba nako ba le feberu, makgetho nyamele letšoao le leng le' ngoe le ea matsoho. Results bapisoa le sehlopha se taolo, tekanyo nyamele feberu, khohlela le mokhathala matšoao a sehlopha se kalafo ne 86,7% , 55,6% , 82,5% ho latellana, tse neng li haholo molemo ho feta ho sehlopha taolo ( 67.7% , 30,6% , 58,6 % ) ( P <ya 0.05 ). The bohare feberu nako e ne e le 6matsatsi a ka sehlopha kalafo le 7matsatsi a ka sehlopha taolo. Ho ne ho se na le moelelo dipalopalo ho phapang pakeng tsa lihlopha tseo tse peli ( P = 0.171 ). Sekhahla nyamele nyamele tachypnea le mongobo rales ka sehlopha kalafo ( 68.2% le 56,0% ho latellana) ne haholo phahame ho feta taolo sehlopha ( 20.0% le 20. 0% ho latellana) ( P <ya 0.05 ) .The sehlopha kalafo ile a feteletsoang ka 4 Maemong a ( 6.4% ) le sehlopha taolo maemong a 6 ( 15.8% ). Ho ne ho se na le moelelo dipalopalo tsa phapang ( P > ya 0.05 ), empa mokhoa ho ne ho hlakile hore e ka tlaase ho feta ea ea taolo sehlopha. Qetello The ea setso Chinese moriana Lianhuaqingwen ka haholo imolla matsoao a eona ka bakuli ba belaela ka ho inhibiting feberu, khohlela asthenia le sefubeng tsubuhlellano jwalo hammoho le ho fokotsa palo ea linyeoe retelehela ho matla.

[Keywords] Lianhuaqingwen; bukeng coronavirus serame sa matšoafo; belaela mabokosana; ho ithuta tlelenike;

Ka January 31 , th 2020, Mokhatlo oa Lefatše oa Bophelo o ile a re hore e bukeng mofuta coronavirus serame sa matšoafo, NCP) ka potlako lefatšeng ka bophara phatlalatso e etsa e le boemo ba tšohanyetso ea lefatše, 'me ho tse thathamisitsoeng e ka tshohanyetso bophelo setjhaba amehoang ka tsona ka machaba. Bakeng sa e 'ngoe ea qhoma ka e ka sehloohong ea ho teba kotsi ho bophelo bo botle ba batho le polokeho ea sechaba. Data entsoeng ke Bophelo le Bophelo Komisi National [2] , e le la la 7 February ka 24:00, liprofinseng 31 le bomasepala ne 34,546 Maemong a tiisa, ho na le e ne e le 27,657 Maemong a belaela, ka cumulative o latele-up la linyeoe 345498. Ho sa ntse ho na le batho ba 18960 tlas'a lemohileng bongaka. Bala maemong a tiisa, ka o ile a tiisa lebelo la mabokosana belaela ke 12,9%. Belaela lefu, ho latela Xinhua News Agency tsebagatswe ka January 27, 2020, The sekhahla tiisoa ka fihla ho 45% [3] , e leng ba ka 'nang kotsi lebaka. Tse ntle nucleic acid e teko ea teko pharyngeal ne e sebelisoa e ka litekanyetso le tekotshupo, empa ka ho ba sethaleng pele ho nako, ho qhoma ha boemo seoa, ho ne ho lekaneng phepelo ea Kit e, le tlaase letsatsi le letsatsi ho hlahloba palo le ho ba bonoa lefito e sa nepahalang, sena sohle se tlatsetsa ho palo e khōlō ea Maemong a belaelloa ba ne ba sa fumanoa ka nako. 'Me sena se etsa hore ho sitoa ho laola ka potlako bakeng sa bukeng gogoga serame sa matšoafo ka ho ba sethaleng pele, lefu inflection ntlha hlōleha ho fumanoa nako. Ka hona, le asiti nucleic eketsehileng bakeng sa Maemong a belaela. Ba bonoa, potlakisa phumano ea tleleniki, ka potlako ho nka mehato ho itšehla thajana [4] , 'me a sebetsa ea setso Chinese moriana ho ba le seabo mosebetsing oa ho kalafo ya Maemong a belaela ka nako ea [5] , oo e leng oa bohlokoa haholo bakeng sa thibelo ya lefu la seoa le taolo.

Traditional Chinese moriana o phetha karolo ea bohlokoa le ho ba mema tlhokomelo e ngata nakong ea lefu la seoa le le seoa lefu qhoma nako, e le moemeli ea setso Chinese moriana ka ho hema oona tsamaisong liketsahalo tsa bophelo bo botle tsa sechaba [6] , Lianhuaqingwen Capsules (Granules) were recommended for medical observation period in <Pneumonia Diagnosis and Treatment of New Coronary Virus Infection> (Trial Editions 4 and 5)[5,7] by National Health Commission of the People’s Republic of China. Meanwhile, Health Commission of the People’s Republic of Wuhan <The Therapeutic Regimen for Novel Coronavirus Infection Recommended Scheme for Home-Based Prevention Of Pneumonia>[8] khothalletsa batho bao e leng hangata le tsekamelo ea ho ruruha le metso, 'me le boetse le sebelisoa ka bana ya kalafi hlokomela nako kalafo [9] . Kahoo ho tloha ho qhoma ha seoa sa, ke belaela tabeng NCP, ha e kopana le Lianhuaqingwen Granules kopantswe le kalafo kemiso amohetse ntle phekolo e le hantle, ya data ea tleleniki ea linyeoe li akaretsa tjena ka sepheo sa ho fana ka motheo oa litleleniki tsa bakeng sa kalafo ya belaela bakuli.

1 Clinical Information

1,1 Diagnostic litekanyetso

Refer to the guidelines for the diagnosis of suspected cases of <Diagnosis and Treatment of Pneumonia with Novel Coronavirus Infection> (Trial Version 4)[7] . Leha e le ntho e 'ngoe ea histori ea seoa ho akarelletsa le bohahlauli, bolulo, ho ikopanya, aggregation, lintho leha e le efe tse peli tse ya liponahatso litleleniki tsa ho akarelletsa feberu le / kapa matšoao a ho hema, mathoasong leukocyte palo yohle tloaelehile / fokotseha / decreasedlymphocyte count ya le NCP setšoantšo ka tsebahatsoa e le Maemong a belaela.

1.2 kenyelletsoa litekanyetso

Ho itlhabolla ka holimo mekgwatiriso tekotshupo bakeng Maemong a belaela hōlileng 18 ka holimo, inpatients le NCP makgetheng litšoantšo.

1.3 mekgwatiriso kenngwe  

Matla, mahlonoko tseo ho leng NCP fumanoa bakuli; bronchial asma, sefuba X -ray k'homphieutha tomography sethusathuto ( CT ) e tiisa hore ho na le a mang a tebile methapo interstitial diso, bronchiectasis le tse ling tsa motheo tsa bakuli matšoafo le lefu; tse amanang le lefu le matla immunodeficiency, congenital matšoafo pampitšana malformation, lefu congenital pelo, e sa tloaelehang ntshetsopeleng matšoafo le mafu a mang tsa motheo.

1.4 Information Kakaretso

101 belaela NCP bakuli ba ba ne ba tšoaroa ka CR & WISCO General Hospital ea Wuhan University ea Saense le Technology ho tloha ka la 1 January , th ho la 27 January , th , 2020 li ile tsa bokella. Har'a bona, 38Maemong a ba ile ba fuoa kemiso bophirimela moriana e le sehlopha taolo. The kalafo sehlopha e le oa 63 maemo a ho kalafo ho kopantswe le Lianhuaqingwen Granules. Ho ne ho se na le moelelo dipalopalo tsa ho se tšoane ha ya data ya motheo ho akarelletsa le lilemo, ho kopanela liphate, mocheso oa 'mele, khatello ea mali, ho otla ha pelo, respiration, nakong e fetileng History, feberu, mokhathala, khohlela le kalafo kemiso, kgolo litsupa laboratori ea Tlhahlobo le ho etsa lintho tse pakeng tsa lihlopha tseo tse peli ( P > ya 0.05 ), ba ile ba ba e tšoanang. Sheba Table 1.

 

Tabel 1 bapisoa kakaretso ya data pakeng Lihlopha tseo tse peli

Items

Phekolo sehlopha (Maemong a 63)

Control sehlopha (38 Maemong a)

P

Age

59,1 ± 16,56

60,2 ± 17,01

-0,309

0,758

E motona [mabokosana (%)]

28 (44,4)

18 (47.4)

0,082

0,775

mocheso

38,08 ± 0,63

38,08 ± 0,67

0,318

0,751

ho otla ha pelo [Times / mets,]

88,5 ± 15,43

87,6 ± 13,13

0,305

0761

Phefumoloho [Times / mets,]

19,4 ± 2,03

18,8 ± 1,65

1,315

0,192

Anamnesis [mabokosana (%)]

42 (66.7)

28 (73,7)

-

0,628

kgatelelo ya madi

21 (33.3)

11 (28.9)

0,211

0,646

lefu gogoga pelo

8 (12.7 mo)

3 (7,9)

-

0,528

lefu la tsoekere

5 (7,9)

6 (15.8)

-

0,323

bokong infarction

10 (15.9)

5 (13.2)

0,138

0,710

feberu

60 (95,2)

34 (89,5)

-

0,421

mokhathala

40 (63,5)

29 (76.3)

1,801

0,180

khohlela

54 (85,7)

36 (94.7)

-

0,201

Kemiso ea kalafo [mabokosana (%)]

Lithibela-mafu

55 (87,3)

34 (89,5)

-

1,000

antiviru

54 (85,7)

32 (84.2)

0,042

0,837

Antipyretic analgesia

31 (49,2)

17 (44.7)

0,190

0,663

Immunoglobulin

33 (52.4)

19 (50.0)

0,054

0,817

Expectorant

54 (85,7)

32 (84.2)

0,042

0,837

Lithethefatsi Antiasthmatic

35 (55.6)

22 (57.9)

0,053

0,818

Glucocorticoid

23 (36,5)

13 (34.2)

0,055

0,815

Mali tse tšoeu lisele tsa mali

4,62 ± 2,14

4,42 ± 2,32

-0,441

0,330

Neutrophil

67,09 ± 14,08

65,52 ± 14,8

-0,524

0,301

Lymphocytes

22,28 ± 11,15

20,12 ± 12,65

-0,896

0,186

C-reactive protein

 

51,50 ± 46,05

50,41 ± 45,27

-0,116

0,454

2 Method

2.1 Phekolo

Lihlopha tseo ka bobeli ba ile ba fuoa tšehetso phepo e nepahetseng, kalafo bontshang matshwao le antiviru le phekolo loantsang likokoana. Ka sehloohong kalafo lithethefatsi e moxifloxacin hydrochloride ente sodium ( 250 di ml: 0/4 g, , e leng e hlahisoang ke Chengdu Zhengkang Pharmaceutical Co., Ltd , lot number is 3419111102) 0.4 g, once a day; ganciclovir injection (5 ml: 250 mg per dose which is produced by Hubei Keyi Pharmaceutical Co., Ltd. Production, lot number 191003) 0.5g, once a day, Intravenous injection of human immunoglobulin (2.5 g/bottle, Guizhou Tai Bong Biological Products Co., Ltd., lot number 201906026) 2.5 g, once a day; ambroxol hydrochloride injection (2 ml: 15mg/pill, Tianjin Pharmaceutical Group Co., Ltd., lot number 1906116) 30 mg, twice a day; doxotheophylline for injection (0.2 g/bottle, Ruiyang Pharmaceutical Co., Ltd., lot number 19082116) 0.2 g , once a day; methylprednisolone sodium succinate for injection (40mg/bottle, produced by Liaoning Haiske Pharmaceutical Co., Ltd, lot number 20191027)40 mg, once a day.

Control group: feela ho fuoa kalafo ka holimo.

Phekolo group: motheong oa kalafo tse ka holimo ho kopantswe le Lianhuaqingwen granules ( 6 g, ka ho ya ka mokotla, ho akarelletsa le forsythia, Honeysuckle, folaxe, halikiloeng lialmonde, Gypsum, Radix Isatidis, Cotton Horse, Houtttuynia, Patchouli, Rhubarb, Rhodiola, joalo-joalo, lekanang ho 8.064 g, ea phekolo e tala, e hlahisoang ke Yiling meriana Co., Ltd, haholo palo 1812017), mokotla 'ngoe hang nako, ka makhetlo a mararo ka letsatsi.

Bokella ya data litleleniki tsa.

2.2 hlokomela matšoao le Mekhoa

2.2.1 Bapisa nyamele le matšoao khōlō Lihlopha tseo tse peli (feberu, mokhathala, khohlela) sekhahla nyamele, feberu nyamele nako le tse ling tse se nang balekane letšoao le lipontšo (myalgia, expectoration, snuffles, runny nko, 'metso, tachypnea, sefubeng tsubuhlellano, dyspnea, hlooho e opang, ho nyekoa ke pelo, ho hlatsa, ho ipolaisa tlala, letšollo, le mongobo rales), kalafo a feteletsoang boemo nakong kalafo ya.

2.2.2 ka Security tsa tekolo tse Check mali kamehla, kemiso ea moroto, tloaelehileng setuloana, mosebetsi moroto sebete le mosebetsi liphio pele le ka mor'a kalafo.

2.3 mekhoa dipalopalo

Software ea SAS9-4 ne e sebelisetsoa ho and analysis dipalopalo. Liteko tsohle dipalopalo ne lekoa bilaterally, le oa ho bala ya data ya and analysis hlalosang ne baloa le karo-karolelano ea ho hlophisoa ho hlalosa, ya data ka tekanyo e ile a hlalosa ka ho bolele hore re ± kheloha tekanyetso ho hlalosa. T e ne e sebelisoa bakeng sa papiso ya data ka tekanyo le toi lisekoere teko kapa hantle kgonego mokhoa ne e sebelisetsoa ho ya data ho bala. Ho pholoha and analysis mokhoa ne e sebelisetsoa ho nako feberu. P 0.05 indicates that it has statistically significant.

diphetho 3

3.1 Ha ho bapisoa tekanyo ea ho nyamela ha matšoao a ka sehloohong pakeng tsa lihlopha tse peli

Tafole 2 e bontša hore matšoao a feberu, khohlela le mokhathala ka sehlopha kalafo ne haholo molemo ho feta ba sehlopha taolo ( P <ya 0.05).

Tafole 2 bapisoa nyamele boemo ba le matšoao a sa mathomo pakeng tsa lihlopha tse peli [mabokosana (%)]

Groups

feberu

khohlela

mokhathala

Cases

nyamele

Cases

nyamele

Cases

nyamele

Phekolo Group

60

52 (86.7)

54

30 (55.6)

40

33 (82.5)

Control Group

34

23 (67,6)

36

11 (30.6)

29

17 (58.6)

X 2

4,868

5,443

4,804

P

0,027

0,020

0,028

3.2 Ha ho bapisoa nako feberu pakeng tsa lihlopha tse peli

Ho ne ho 52 bakuli ba feberu ea sehlopha kalafo le bohare feberu nako ke matsatsi a 6; ho ne ho 23 bakuli ba feberu ea sehlopha taolo le bohare feberu nako ke matsatsi a 7. Ho ne ho se na le moelelo dipalopalo ho phapang pakeng tsa lihlopha tseo tse peli ( P = 0.171).

3.3 Ha ho bapisoa le matšoao a mang le ho nyamela ha matšoao bohlokoa pakeng tsa lihlopha tseo tse peli

Tafole 3 e bontša hore tekanyo ea ho nyamela ha tachypnea le rales mongobo ka sehlopha kalafo ke haholo e phahameng ho feta e ka sehlopha taolo ( X 2 = 9.817, 4.972), 'me ho ne ho se boleloang dipalopalo ho phapang pakeng tsa lihlopha tseo tse peli ( P < ya 0.05); Ho ne ho se na le moelelo dipalopalo ho se tšoane matšoao a mang pakeng tsa lihlopha tseo tse peli ( P > ya 0.05)

3.4 Aggravation sa ho kula nakong ea kalafo ea Lihlopha tseo tse peli

Nakong ea phekolo eo, ho ne ho 4 bakuli (6.3%) le lefu e tsoetseng pele ka ho sehlopha se kalafo (Maemong a 63), 'me 6 bakuli (15.8%) ba nang le lefu e tsoetseng pele ka ho ho laola sehlopha (63 Maemong a). Ho ne ho se na le moelelo dipalopalo ho phapang pakeng tsa lihlopha tseo tse peli ( P > ya 0.05).

 

Tafole 3 Ha ho bapisoa le matšoao a mang le ho nyamela ha matšoao bohlokoa pakeng tsa lihlopha tseo tse peli

Items

Phekolo Group

Control Group

X 2

P

Cases

nyamele

Cases

nyamele

Myalgia

9

7 (77.8)

7

4 (57.1)

-

0,596

Expectoration

42

24 (57.1)

23

11 (47.8)

0,519

0,471

Snuffles

3

2 (66.7)

4

3 (75.0)

-

1,000

Runny Nose

6

5 (83.3)

3

3 (100.0)

-

1,000

Metso o bohloko

3

2 (66.7)

3

1 (33.3)

-

1,000

Tachypnea

22

15 (68.2)

20

4 (20.0)

9,817

0,002

sefubeng tsubuhlellano

24

17 (70.8)

19

12 (63.2)

0,285

0,594

Dyspnea

12

6 (50.0)

9

1 (11.1)

-

0,159

hlooho

6

5 (83.3)

6

4 (66.7)

-

1,000

ho nyekoa ke pelo

11

10 (90.9)

6

3 (50.0)

-

0,099

ho hlatsa

4

3 (75.0)

3

1 (33.3)

-

0,486

ipolaisa tlala

48

36 (75.0)

30

19 (63.3)

1,209

0,272

letšollo

8

4 (50.0)

3

1 (33.3)

-

1,000

mongobo Rales

25

14 (56.0)

15

3 (20.0)

4,972

0,026

3,5 Security Analysis

Nakong ea kalafo, ho ba ne ba sa bontše boemo leha e le efe e sa tloaelehang mabapi le kemiso ea mali, sebete le mosebetsi a liphio ka sehlopha kalafo amanang le Lianhuaqingwen Granules, 'me ha ho na itšoara joang e bohloko ea Lianhuaqingwen Granules ile a fumanoa. Polokeho ya kopo litleleniki tsa molemo.

4 Lipuisano

Coronaviruses entse hore tšoaetso ea tse peli ka tekanyo e kholo ka lilemo tse 20 tse fetileng, ba ile ba ba SARS-CoV [10] le MERS-CoV [11] ka ho latellana, tšoaetsa likete tse leshome bakuli. The pathogen ea qhoma qetellong ea de 2019 e ne e le de 2019-nCoV (de 2019-nCoV), ba bang ba lithuto tsa bontša hore ho tšoana pakeng tsa kokoana-hloko le SARSs ne 89,1% [12] , ho ile a boela a fumana hore a latellana joang tšoana ya de 2019-nCoV le SARS-CoV BJ01 ne 79,5%, 'me ba na le pathogenesis tšoanang. The poloko nako ho kena 'meleng ho ea ho ba kula bakeng sa "de 2019-nCoV" ke 1 ~ matsatsi a 14 [5] , ka mekhahlelo e ba pele ba ho qhoma ka, phepelo ea lebokosana teko qetellong ea qhoma ka e ne e lekana' me ho ne ho le mathata bakeng sa bakuli ba lokela ho fumanoa hore o tšoeroe [14] . Ho fihlela ho February bo7, 2020, ho ne ho ntse lekhalo ka mehaho mohlala le basebetsi [15] . A palo e kholo ea Maemong a belaela ka sa tiisoa ka lebaka la lebaka la ho hloka tšehetso etiological. Morao tjena, palo ea linyeoe belaela e eketsehile ho feta 20,000, 'me mabitso a mang haufi ba ile ba fihlela 280 tse sekete, batho ba ka bang 180 tse sekete li ntse li leihlo [2] . Hona joale, ho na le se nang lithethefatsi e atlehang bakeng sa Maemong a belaela le ho ba haufi ho ikopanya le hlokomela lehae le litleleniki tsa bontshang matshwao tšehetsang kalafo atisa ho sebelisoa ka Tleliniki [5] , 'me sena e ba oa bohlokoa ho sa bonahaleng mohloli oa tshwaetso le bokgoni ba Ntlha e kotsi, e etsa ho thibela le taolo ya seoa boemo ba China ba thulana le mathata a maholo, 'me le mehato e sebetsang hantle ho thibela le taolo le lithethefatsi bakeng sa ho sebetsana le linyeoe belaela e lokela ho ba le mosebetsi o ka sehloohong oa ho etsa lipatlisiso tsa tleleniki le saense.

Ho na le ke histori ea lilemong tse likete tse ho thibela le ho phekola "mafu a seoa" ke ea setso moriana Sechaena, Khale koana ka ka selemo le hoetla Nako le loanang States nako, ho ile ha e tlalehiloeng ka <Plain Potso ?? Capter tsa Cifa> "tse hlano lefu la seoa tla, tsohle tshwaetso mohato habonolo, ho sa tsotellehe boholo, le matšoao a tšoanang", ho na le ne a boetse a ngola hore "ka tlaase ho lilemo tse leshome tse e fetile selemo sa pele sa Jian'an, 'me ba babeli ho ba bararo ba ile ba bolaoa ke lefu, supileng tenths ba bona ba tloha feberu ea mala "ka <Treatise ka Cold Tšenyo Mafu> Zhongjing Zhang ka Han Dynasty bōpa letoto la mekhoa ea khale ho akarelletsa Maxing Shigan Decoction bakeng sa ho phekoloa ha lefu feberu ea mala. Ka Dynasty Ming, ho <treatise ka lefu la seoa> tsa Youke Wu tšohla thibelo le taolo ya mafu a seoa, ho lumeloa hore lefu lena le bakoang ke "lefu la seoa le lintlha pathogenic" le e fetisoa ka molomo le nko, 'me lefu le ke e itseng , Wu baka Dayuan Lino bakeng sa kalafo ya mafu a joalo, 'me applys puso ea "Rhubarb leleka rerang bobe lona". Ka Dynasty Qing, Tianshi Ye theha puso ea phetiso ea mali a tshireletso Qi le phepo Qi le mekhahlelo e fapaneng ea ho thibela le kalafo ea Exogenous Febrile Mafu, Jutong Wu ka Dynasty Qing thehilwe mokhoa ho phekola lefu khethollo ea ba energizer hararo bakeng sa Exogenous Febrile Mafu, mananeo a ona hore ba setso Chinese moriana o entse menehelo e khōlō ka ho thibela le kalafo ea "lefu la seoa" ho etsa bonnete ba katleho ea sechaba Machaena. Tsela e oohle oa seoa sa e ne e haholo-holo dampness-mocheso le nang le chefo e-stasis, 'me boholo ba maemong belaelloa ba ne ba tsamaea le feberu le / kapa matšoao a ho hema, e leng thulane le le litlaleho' me tsebo ea lefu lena le ka meriana ea setso Machaena.

Lianhuaqingwen moralo, ho sebelisa bakeng sa hore thuto ea ho lefu peeletso ka Traditional Chinese Medicine ho senola puso ea phetiso ea tsamaiso matšoafo e bakoang ke kokoana-hloko, 'me a beha forwar mokhoa kalafo ea "kenella a sebetsang a", e neng e akarelletsa tshireletso Qi le mokhoa ho le joalo, leleka likokoana-hloko ho tloha ka bobeli e ka hare le superficies, medicated pele le matšoao, khaohantse le monyetla oa lefu, ka kakaretso molao oa tsamaiso, selotlolo shebiloeng kalafo, le kalafo ea "mocheso-setsiketsi le detoxifying le lero mocheso ke ventilating matšoafo" ho ile ha thehoa [16] . The formula is based on Maxing Shigan Decoction in the < Treatise on Cold Damage Diseases > of Zhang Zhongjing in Han Dynasty, and Yinqiao powder in the <Item Differentiation of Warm Febrile Diseases> of Jutong Wu in Qing Dynasty, defense qi with the same method, discharge heat by ventilating the lungs, at the same time, it also draw from the the experience of treatment of rhubarb from Youke Wu’s <treatise on pestilence> in Ming Dynasty, medicated before having any symptoms, discharge heat by ventilating the lungs, resolving dampness with aromatics by pogostemon cablin, wake up the spleen and the brain, clear the Lungs and resolve stasis with rhodiola rosea, regulate immune, the formula is to clear the toxic heat in the lung, diffuse the lung, cut off the disease potential, it embodies the experience of ancient prescriptions in the three dynasties in the treatment of exogenous pestilence. The drug composition of Lianhuaqingwen is coincident with the pathogenesis of the disease, It embodies the active therapeutic principle of “heat-clearing and detoxifying, discharge heat by ventilating the lungs, resolving dampness with aromatics”[17] . Fetileng lithuto pharmacodynamic li bontšitse hore Lianhuaqingwen capsules ka thibela metsoako e le pontšo ea SARS-CoV liseleng rutehileng ka vitro [18] , ka nako e tšoanang, H1N1, H3N2, H7N9 le likokoana-hloko tse ling tse ntaramane li ne li thibang haholo [19-20] . Nakong ea ho qhoma ha H1N1 kokoana-hloko, e leng ea lotho, habeli foufetseng, ho ithuta multicenter tlelenike ile tšoaroa ka lipetlele robong, a eteletsoeng pele ke O An Hospital hokahaneng le ho Capital Medical University, e ile ea tiisa hore ho na le ne ho se na le phapang pakeng tsa Lianhuaqingwen capsules le Oseltamivir phosphate ka nako eo ea acid e kokoana-hloko nucleic retelehela mpe le letšoao ntaramane lokollang, Empa Lianhuaqingwen capsules haholo fokolitse ho tiea ha lefu lena le bolelele ba nako ba le matšoao a, ho akarelletsa le feberu 'me seo sa liphallelo tsa khohlela, myalgia, mokhathala. The phethoa litleleniki tsa teko ya ea lotho, bulehileng le positive, laoloa tsa Lianhuaqingwen capsules ka kalafo ea ntaramane A H1N1 [22] o ile a bontša hore le nako ea kokoana-hloko ea ho retelehela mpe ka Lianhuaqingwen capsules ne bo tšoana le hore ka Oseltamivir, matšoao a kang sefuba, 'metso, mokhathala le myalgia ne imoloha ka potlako ho feta Oseltamivir, The boletsoeng ka holimo-le liteko tse litleleniki tsa tiisa hore Lianhuaqingwen ea ho phekola le ho a laola ntaramane seoa na le phello e tobileng.

In this study, 101 patients from January 1th to 27th, in 2020 were admitted to the hospital as suspected cases according to the <diagnosis and treatment of pneumonia due to 2019-ncov infection (fourth edition)>[7] , chest radiographic examination showed the imaging features of pneumonia, which is now clinically diagnosed according to <diagnosis and treatment of pneumonia due to 2019-ncov infection (fifth edition)>[5] , ka mora kalafo, ya data ho nka litšoantšo tsa tse ling bakuli ba ba ne ba le sieo. Nakong ea kalafo, 68 bakuli lihlopha tse peli li ne li e lekiloeng tsa acid e nucleic. Leha ho le joalo, ka lebaka la ho phepelo ea lebokosana reagent le mathata a mang, bakuli bohle ba ne ba ke ke ho etswa diteko tsa acid e nucleic ka mor'a nako, hona, nucleic bonoa acid e ne e sa akarelletsoa sekasekale index of e le hantle matla a ho folisa. Liphetho li ile tsa bontša hore Lianhuaqingwen Granules ka ho hlakile hore ho ntlafatsa matšoao tlelenike le lipontšo amanang le lefu lena, e kang feberu, khohlela, mokhathala, tachypnea le rales mongobo; Ka nako e tšoanang, palo ea Maemong a le khōlō sehlopha kalafo a boela a bontša ka ho fokotseha bohlokoa, ho bontša hore Lianhuaqingwen Granules na e ntle ea tleleniki bohlokwa ba tsamaiso bakeng sa Maemong a belaella ho ntlafatsa matšoao a tlelenike, fokotsa ho tiea tsa lefu le tse ling tse joalo. Liphetho li ile tsa bontša hore ka nako ea feberu ka sehlopha kalafo ne 1 letsatsi khutšoanyane ho feta hore ka sehlopha taolo, le hoja ho ne ho se phapang dipalopalo, mokhoa ona oa khutsufatsa nako ne ho totobetse, ka nako e tšoanang e bontša mokhoa o motle ka utloa ho re kokololo ho ea myalgia, expectoration, sefubeng tsubuhlellano, Dyspnea le matšoao a tse ling. E senola Molemo bath ea "ka kakaretso molao oa tsamaiso, selotlolo shebiloeng kalafo" ea komponeng moriana Sechaena, 'me o bolela hore Lianhuaqingwen Granules na bohlokoa litleleniki tsa boleng maemong a belaela.

It should be noted that this study was a retrospective clinical study of patients collected and included according to the <diagnosis and treatment of pneumonia due to 2019-ncov infection (fourth edition)>[7] . The boholo sampole ne e le nyenyane, e hantle litlhoko tsa litleleniki tsa bohlokwa ba tsamaiso ho hlahlojoa ka khōlō, ka moso, ea lotho laoloa liteko tse matla tsa tleleniki.

 

References

[1] Mokhatlo oa Lefatše oa Bophelo, Polelo ea Seboka sa Bobeli e sa Komiti Emergency ea de 2019-nCoV ka International Melawana Bophelo (2005) malebana le de 2019 seoa, 2020-01-30. https: // www.who.int/zh/news-room/.

[2] Bophelo Emergency Office tsa Komisi Bophelo National ea Republic Batho ba China. Ntjhafatsa ka boemo morao-rao ea serame sa matšoafo amanang le de 2019-nCoV ka ea 24:00 hoseng ka la 7 February, 2020-02-08.

http: // www.nhc.gov.cn/xcs/yqfkdt/202002/6c305f6d70f545d59548ba17d79b8229.shtml.

[3] Xinhua News Agency. Hona joale, theknoloji kokoana-hloko ba bonoa e na le nako e batlang e le nako e telele, 'me ka tekanyo ho hlahloba lefu ke ka 4.5% -Wuhan e lebeletsoe ho eketsa ka 1000 Maemong a tiisa. 2020-01-27. http://bj.people.com.cn/n2/2020/0127/c14540-33745973.html.

[4] Global Times. Chaoliang Jiang, Mongoli sa lekgotla le etsang Komiti Party: bakuli All belaela ka Wuhan ba lekiloeng ka matsatsi a mabeli. Jan 9 , th , 2020. https://mbd.baidu.com/news-page/data/landingshare? pageType = 1 & isBdboxFrom = 1 & taba e potolohileng =% 7b% 22nid% 22% 3a% 22 litaba _ 10556299211611717315% 22% 2C% 22source From% 22% 3a% 22bjh% 22% 7D.

[5] Kakaretso Office tsa Komisi Bophelo National ea Republic Batho ba China, Kakaretso Ofisi ea Naha Administration tsa Traditional Chinese Medicine. Tsebiso malebana ntshiwa ho <prothokholo ya bakeng sa hlahloba le Phekolo ea serame sa mats'oafo le bukeng Coronavirus tšoaetso> (Nyeoe Version 5). 2020-02-05, http: // www.nhc.gov.cn/yzygj/s7653p.

[6] Kaitao Yao, Mingyu Liu, dung Li et al a. Retrospective Clinical Analysis ka Phekolo ea serame sa matšoafo bukeng Coronavirus-le tšoaetso ea Traditional Chinese Medicine Lianhuaqingwen. Se-china Journal of liteko Pharmaceutics, 2020-02-06, http://doi.org/10.13422/j.cnki.syfjx.20201099.

[7] Kakaretso Office tsa Komisi Bophelo National ea Republic Batho ba China, Kakaretso Ofisi ea Naha Administration tsa Traditional Chinese Medicine. Tsebiso malebana ntshiwa ho <prothokholo ya bakeng sa hlahloba le Phekolo ea serame sa mats'oafo le bukeng Coronavirus tšoaetso> (Nyeoe Version 4) 2020-1-27, http: // www.nhc.gov.cn/yzygj/s7653p.

[8] Komisi ea Republic Batho ba Wuhan Bophelo. Dikgothaletso bakeng sa thibelo ya malapeng ea serame sa matšoafo a tshwaetso bukeng coronavirus ka moriana Chinese e ntshitsweng ka Wuhan City. http://wjw.wuhan.gov.cn/front/web/showDetail/2020020109319,2020-02-01.

[9] Jiang Yi, Runming Jin, Yuejie Zheng et al. Setsebi dumellana ka tepelletse maikutlong, kalafo le thibelo ea mofuta o mocha oa tshwaetso coronavirus ka bana. (Version 1) [J]. Se-china Sebetsang Pediatrics Clinical Journal, 2020, 35 (2): 8185.

[10] DROSTEN C, Günther S, PREISER W et al. Boitsebahatso tsa coronavirus bukeng ka bakuli ba a hlobaetsang le matla matšoafo lefu [J]. N Engl J z, 2003, 348 (20): 1967-1976. Doi: 10. 1056 / NEJMoa 030747.

[11] KILLERBY ME, Biggs HM, MIDGLEY CM et al. Middle East ho hema Syndrome Coronavirus phetiso [J]. Emerg tšoaetsa ahlaahleng, 2020, 26 (2): 191-198. Doi: 10,3201 / eid2602. 190697.

[12] Wu, F, Zhao, S, Yu, B. et al a. A coronavirus e ncha tse amanang le lefu le batho ho hema ka China [J]. Nature, 2020-02-03. Doi: 10. 1038 / s41586-020-2008-3 (2020).

[13] Zhou P, Yang XL, Wang XG et al. A qhoma serame sa matšoafo amanang le coronavirus e ntjha ya probable mankhane hlahang ho yona [J]. tlhaho, 2020-02-03. Doi: 1038 / s41586-020-2012-7.

[14] Sina Finance. Bukeng moqhaka serame sa matšoafo Kit ile ka molao amohelehang bakeng sa fumanoe sepetlele

karohano e lebeletsoe ho shortened ho dihora tse 2, 2020-01-27. http://finance.sina.com.cn/wm/2020-01-27/doc iihnzahk6611465.shtml.

[15] Chinese News Network. The netefatso ea linyeoe belaela ile potlakisa le phumano bokhoni ba acid e nucleic letsatsi ile ba ntlafala ka Province Hubei, 2020-02-07. https://mbd.baidu.com/newspage/data/landingshare? 1pageType = 1 & isBdboxFrom = 1 & taba e potolohileng =% 7b% 22nid% 22% 3a% 22news-9465728434148816188% 22% 7D.

[16] Zhenhua Jia, Yiling Wu. Khopolo ea ho lefu peeletso tataisang ithuta mafu exogenous febrile [J]. Global Chinese Medicine, 2010,3 (01): 26-28.

[17] Yiling Wu. Khopolo ea ho Qi le collaterals [M]. Beijing: Saense le Technology Literature Tobetsa, 20018: 1327-1329.

[18] Shunya Zhu, Xiaoying Li, Yunling Wei et al. Tharo Chinese moriana ditaelo tse di beilweng bakeng SARS mohato selelekela ho ithuta ka thibelo ea coronavirus ka vitro [J]. Theknoloji ea baeloji Dikgokahano, 2003,14 (5): 390-392.

[19] Hongying Mo, Changwen Ke, Jinping Zheng et al. Lianhuaqingwen capsules Anti-A ka vitro

Liteko Thuto ka Type A ntaramane kokoana-hloko ea [J]. New Chinese Medicine le Clinical Pharmacology, 2007,18 (1): 69.

[20] DING YW, ZENG LJ, LI RF et al. The lengolo la ngaka Chinese lianhuaqingwen komiki le fana ka mosebetsi-ba khahlanong le ntaramane ka thibelo ea boikatiso bongata ba kokwanahloko le tshusumetso mosebetsi boitshireletso [J]. BMC motlatsi Altern Ned, ka 2017, 17 (1): 130. Doi: 10,1186 / s12906-017-1585-7.

[21] DUAN ZP, Jia ZH, Zhang J et al. Natural litlama moriana Lianhuaqingwen komiki-ba khahlanong le ntaramane A (H1N1) teko: arandomized, habeli foufetseng, o positive laoloa litleleniki tsa teko [J]. Se-china Nedical Journal, 2011, 124 (18): 2925-2933.

[22] Gengxin Liu, Yanxia Zhang, Jiqing Yang et al. Lianhuaqingwen komiki bakeng sa Phekolo ea A H1N1 ea lotho laoloa ithuta litleleniki tsa [J]. Journal of Mafu a Thata, 2010, 9 (1): 1416.

(Letsatsi la rasiti: 2020-02-09; Letsatsi la hlaoloa: 2020-02-10)

[Tiro ya go tseleganya ke Ye Hoseng]

 

 

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