Clinical katleho Analysis ka 54 NCP Cases ka Phekolo ea Lianhuaqingwen Granules Cheng Dezhong, LI Yi

(The Hospital Puren hokahaneng tsa Wuhan University ea Saense le Technology, Wuhan 430081, China)

Inahaneloang Sepheo : Ho hlahloba katleho ea tleleniki ea Lianhua Qingwen Granules (LH-C) ka bukeng coronavirus serame sa matšoafo (NCP) bakuli. Mekhoa : The ya data ea tleleniki ea 54 tlwaelehileng NCP Bakuli ba ne retrospectively hlahlobile ka Puren hokahaneng Hospital Wuhan University ea Saense le Technology. Results: Ka mor'a kalafo le LH-C bakeng sa matsatsi a mararo a latellanang. Tekanyo ea matšoao a nyamele ka feberu, asthenia le khohlela ne 47,5%, 35,1%, le ho 20,0%, ka ho latellana. Matsatsi a mahlano hamorao, tekanyo ea matšoao a nyamele ka feberu, asthenia le khohlela eketsehile ho 62,5%, 59,5%, le ho 50,0%, ka ho latellana. Ke letsatsi la bosupa, tekanyo ea matšoao a nyamele ka feberu, asthenia le khohlela fihla ka 80,0%, 75,7%, le ho 76,7%. The a matšoao a nyamele ka feberu, asthenia, le khohlela ne 3,6 ± 2,14 matsatsi a, 4.1 ± 2,58 matsatsi a, 'me 5.3 go ± 2,63 matsatsi. Ha e le matšoao a mang nyamele ka sefubeng stuffiness, le dyspnea, le crackles mongobo ne 84,6%, 100%, le ho 89,5%; le bokgoni palo yohle e ne e le ho fihlela ho 81,6%, ntle le litla-lemohiloeng bapile ka letsatsi la bosupa. Qetello : LH-C ka haholo imolla matsoao a eona litleleniki tsa bakuli ba tloaelehileng NCP ke inhibiting feberu, asthenia, le setulo se kang bethe, le fokotsa bolelele ba nako ea bona. All liphetho tsena feela selelekela bopaki bo tlelenike bakeng LH-C ka NCP kalafo.

Keywords: Lianhuaqingwen; SARS-Cov-2; NCP; Clinical bohlokwa ba tsamaiso; Retrospective and analysis; Maemong a tloaelehileng

Se-china tlhophiso palo: R254.3; R256.19; R512.99

Tokomane boitsebiso khoutu: A theo: 10. 3969 / ya j. Issn. 1673-7202. 2020. 02. 006

Morao tjena, e bukeng coronavirus serame sa matšoafo (bukeng Coronavirus serame sa matšoafo, NCP) seoa e se e ho jala le ho ho ile classified e le Class B mafu a tšoaetsanoang (khona ka lefu le Class A) [1] . Linaheng tse fetang 20 le libaka tse lefatšeng ba tlalehile Maemong a tiisa, 'me e e-ba lefatšeng lohle bophelo setjhaba ketsahalo [2] . Matšoao o ka sehloohong oa NCP ke feberu, asthenia le khohlela omileng. A bakuli 'maloa ba le matšoao a kang obstruction nasal, nko runny,' metso le letšollo. E ile ea tlaleha hore 15,7% ea bakuli NCP ba ile a lumela ho ea sepetlele, 'me ea litleleniki shoang e ka 1.4% [3] . Ba bang ba lithuto tsa boetse li bontša hore 26% ya bakuli hloka kalafo ka matla unit trust tlhokomelo, 'me e shoang ea bakuli o ile a tiisa e 4.3% [4] ,' me lieha ho kalafo, phello phekola bo tebile ka ho fetisisa. Leha ho le joalo, ho fihlela ho hona joale, ha ho na e atlehang antiviral moriana bakeng sa NCP, empa letšoao thehiloeng therapiesare haholo-holo sebelisoa. Re ne re sebelisa Lianhuaqingwen Granule kopantswe le kalafo kemiso ea ho tšoara lefu lena le o ile a fumana litholoana tse molemo. Ka hona, re mona tlaleha and analysis retrospective ka ya data ea tleleniki ea 54 NCP bakuli sepetlele rona, e le hore ho ntlafatsa boemo ba kalafo ea lefu lena.

  1. 1.        Data le mekhoa

1,1.       Kakaretso ya data liphofu Research ke Maemong a 54 tsa lipale serame sa matšoafo coronavirus eo ba ne ba tšoaroa ka Lianhuaqingwen Granules kopantswe le kalafo tloaelehileng (ho ea ka leihlo la lefu, a le fa tšehetso phepo e nepahetseng, kalafo antiviral le kalafo antibacterial) ho tswa January 1-31, 2020 ka Puren Hospital hokahaneng le Wuhan University ea Saense le Technology. A le lilemo li karolelano ea bakuli ne 60,1 ± 16,98 lilemo, kenyeletsa 29 motona (53.7%) le tse 25 e motšehali (46.3%); ka karolelano mocheso oa 'mele e ne e le (37.93 ± 0.93) ℃, le bohare mocheso oa' mele e ne e le 38,05 ℃, le mocheso lebetsoeng le 'mele oa pele tepelletse maikutlong e ne e (38.54) ± 0,60) ℃; karolelano lebelo leo pelo e ne e 87,9 ± 11,80 otla / mets, tekanyo bohare pelo ile 85,5 otla / mets, tekanyo phahameng ka ho fetisisa e ne e le 112 otla / mets; le respiration karolelano e ne e 21,1 ± 3,78 breaths / mets, tekanyo bohare ne 20,0 breaths / mets, tekanyo phahameng ka ho fetisisa e ne e le 30,0 breaths / mets; le ba nang le histori ea kgatelelo ya madi e ne Maemong a 21 (38.9%), le ba nang le histori ea lefu gogoga pelo ne 7 Maemong a (13%). Ho ne ho 10 maemo a ho lefu la tsoekere mellitus (tsa 18.5%), Maemong a 10 infarction bokong (tsa 18.5%). Ho itlhahloba laboratori ea: Maemong a 31 (64.6%) ba leucocytes ka mefuta e fapaneng tloaelehileng, mabokosana 9 (18.8%) theola ho feta boleng ba tloaelehileng, mabokosana 8 (16.7%) phahame ho feta boleng ba ntho e tloaelehileng; 25 Maemong a (52.1%) ba neutrophils ka mefuta e fapaneng tloaelehileng, Maemong a 23 (47.9%) ne e phahameng ho feta boleng ba ntho e tloaelehileng, 14 Maemong a (29.2%) ba ne ba le fapaneng tloaelehileng, Maemong a 34 (70.8%) ne tlaase ho feta boleng ba e tloaelehileng ; bakuli bohle ba ne C-arabelang protheine maemo phahame ho feta e tloaelehileng. Bakuli bohle ba ne ba tšoaroa ka Lianhuaqingwen Granules bakeng sa karolelano ea 8,0 ± phahameng 4.10 matsatsi a, ka bohare ba matsatsi a 7,0, bonyane ba matsatsi a 1,0 le palo e kahodimodimo ea matsatsi a 16,0.

Tafole 1 Kakaretso Information tsa NCP Bakuli

ntho

Cases

(Count ya)

Sephetho

Project

Cases

(Count ya)

Sephetho

Age

54

60,10 ± 16,98

lisele tse Mesenchymal (%)

Man (%)

29

53,7

Normal

25

52,1

'mele mocheso

54

37,93 ± 0,93

Low

0

0.0

Pelo Rate (lv / mets)

54

87,90 ± 11,80

phahameng

23

47,9

Respiration sekhahla (breaths / mets)

54

21,10 ± 3,78

The lymphocyte (%)

histori Medical

Normal

14

29,2

Phahameng khatello ea mali

21

38,9

Low

34

70,8

lefu gogoga pelo

7

13

phahameng

0

0.0

lefu la tsoekere mellitus

10

tsa 18.5

C-arabelang protheine (%)

bokong infarction

10

tsa 18.5

Normal

0

0.0

lisele tse tšoeu mali (%)

Low

0

0.0

Normal

31

64,6

phahameng

44

100,0

Low

9

18,8

Matsatsi le ho phekoloa Lianhuaqingwen Granules

54

8,0 ± phahameng 4.10

phahameng

8

16,7

1.2.       Diagnostic mekgwatiriso Bakuli ba ne fumanoa ka NCP boikutlo bo nepahetseng ha ba ne ba kopana ka litekanyetso le tekotshupo coronavirus tshwaetso bukeng (teko tlhahiso bohlano) bakeng sa [5] , 'me o ile a bontša liphello tse ntle le teko nucleic acid e ao etselitse sekhohlela,' metso swab le theola matšoafo pampitšana maro.

1.3.       Mekgwatiriso kenyeletso The tloaelehile [5] ka-bakuli ba ke khale tse fetang 18 lilemo tse 'me ea kopana le NCP tekotshupo mekgwatiriso.

1.4.       Mekgwatiriso kenngwe 1) Matla le mahlonoko tseo ho leng NCP bakuli; 2) leha e le efe sa foleng matšoafo mafu, ho hema baktheria tšoaetso ea kang tonsillitis suppurative, a hlobaetsang le tracheobronchial la bronchitis, sinusitis, nattokinase mecha ea phatlalatso le mafu a mang ho hema tse amang litleleniki tsa teko sekasekale; 3) le e matla immunodeficiency mathomo, fitlhelelwang immunodeficiency syndrome,, congenital matšoafo malformation congenital lefu la pelo, dysplasia methapo le mafu a mang tsa motheo.

1.5.       PhekoloLianhuaqingwen Granule ile ka molomo nkiloeng, 1 mokotla / nako, 3times / d '(Beijing Yiling, gyzz20100040.); The phekolo lithethefatsi ka sehloohong e ne e le intravenous ente ea immunoglobulin batho (Guizhou Taibang Biological Products Co., Ltd., GJZ s20023034) 2.5g, hang ka letsatsi; ganciclovir ente (Hubei Keyi meriana Co., Ltd., GJZ h10980188) 0.5g, hang ka letsatsi; Levofloxacin Hydrochloride ente (Hu Hu Nanwuzhoutong meriana Co., Ltd., gjzz h20083916) 0.4g, hang ka letsatsi; Methylprednisolone sodium Succinate bakeng sa ente (Liaoning hisico meriana Co., Ltd., gjzz h20133234) 40mg, hanngoe ka letsatsi.

1,6.       Lemohileng index ea The ya data ea tleleniki ea 54 NCP bakuli li ne li hlahlobisisa, ho akarelletsa le sekhahla nyamele le matšoao a ka sehloohong (feberu, asthenia, khohlela) ka mora 3, 5, matsatsi a 7, nyamele a feberu le matšoao a ba bang le matšoao.

1,7.       Mekgwatiriso tsa bohlokwa ba tsamaiso sekasekale The letšoao se seholo "ha ho na" e nkiloe ka 0 ntlha, le "e" e le 1 ntlha. (pele ho kalafo - mora kalafo) / pele kalafo ke sekhahla phokotso letšoao lintlha, ha lintlha ke ho feta 30%, e nkoa e le kalafo e atlehang, ha lintlha ke ka tlaase ho 30%, e nkoa e le kalafo thuso, ha lintlha ke ho feta 30%, e nkoa e le e atlehang kalafo / palo yohle ya mabokosana mora kalafo ka kalafo bokgoni e atlehang, ho bokgoni kalafo ea bakuli bohle ba ka mor'a 3, matsatsi a 5 le ea 7 ea kalafo e hlahlobisisa.

1,8.       Dipalopalo mokhoa ithuta ena sebedisa SAS 9.4 botshelo Software bakeng sa and analysis hlalosang, ya data tshephile o hlalosoa ka palo ea linyeoe le ea ho hlophisoa karo-karolelano, ya data ka tekanyo e hlalositsoeng ke li bolela'ng ± tekanyetso kheloha kapa bohare, le ya data ya motheo le bohlokwa ba tsamaiso index ya ntlha ka 'ngoe ho etela ba hlalosoa le li hlahlobisisa.

  1. 2.        Sephetho

2.1.       Nyamele tekanyo ea matšoao a ka sehloohong (feberu, asthenia, khohlela) 1) Pele kalafo ea, ho ne ho Maemong a 40 la feberu (74.1%), Maemong a 37 ea asthenia (68.5%), Maemong a 30 ea khohlela (55.6%); 2) Ka mor'a matsatsi a 3 ea phekolo, ho ne ho Maemong a 19 of feberu (47.5%), Maemong a 13 of asthenia (35,1%), 6 maemo a ho khohlela (20.0%); 3) Ka mor'a hore matsatsi a 5 ea phekolo, feberu ea nyamela maemong a 25 (62.5%), asthenia maemong a 22 (59.5%), khohlela maemong a 15 (50.0%); 4) Ka mor'a matsatsi a 7 of kalafo, feberu ea nyamela maemong a 32 (80.0%), asthenia maemong a 28 (75.0%) The matšoao a khohlela nyamela maemong a 23 (76.7%). Sheba Table 2 le Figure 1.

 

 

Tafole sekhahla 2 nyamele le matšoao a ka sehloohong bakuli NCP (%)

Project

Case Number Pele kalafo

Fokotswa mabokosana mora kalafo 3d

Fokotswa mabokosana mora kalafo 5d

Fokotswa mabokosana mora kalafo 7d

Feberu (n g = 54)

40 (74,1)

19 (47.5)

25 (62.5)

32 (80)

Asthenia (n g = 54)

37 (68,5)

13 (35,1)

22 (59.5)

28 (75,7)

Khohlela (n g = 54)

30 (55.6)

6 (20.0)

15 (50.0)

23 (76,7)

2.2.      
Main symptoms (fever, asthenia, cough) disappeared time 1) The average disappearance time of fever symptoms was (3.6 ± 2.14) days, median disappearance time was 3.0 days, with the shortest time as 1.0 days and the longest time as 8.0 days; 2) the average disappearance time of asthenia symptoms were (4.1 ± 2.58) days, median disappearance time were 4.0 days, the shortest 1.0 days, the longest 12.0 days; 3) the average disappearance of cough symptoms days (5.3 ± 2.63) d, median disappearing days (5.0 d), minimum disappearing days (1.0 d), maximum disappearing days (12.0 d).

71
Figure 1 nyamele tekanyo ea matšoao a ka sehloohong bakuli NCP

81

Figure 2 nyamele tekanyo ea matšoao a ba bang 'me le lipontšo bakuli NCP

85

Figure 3 Phekolo ka bokgoni ba ho bakuli NCP

2.3.       Nyamele tekanyo ea matšoao a ba bang 'me matšoao 1) Pele kalafo: Maemong a 13 (24.1%) ne sefubeng mahlomola, mabokosana 8 (14.8%) ne dyspnea, Maemong a 10 (tsa 18.5%) ne ho ipolaisa tlala,' me 19 Maemong a (35.2%) ne rales mongobo ; 2) matsatsi a 7 ka mor'a kalafo: Maemong a 2 ne sefubeng mahlomola, le Maemong a 11 (84.6%) nyamela, 0 Maemong a ne dyspnea, ka 8 Maemong a nyamela. Ho ne ho 6 maemo a ho ipolaisa tlala, le mabokosana 4 odisappeared (40.0%), Maemong a 2 ya rales mongobo, le Maemong a 17 nyamela (89.5%). Sheba Table 3 le Figure 2.

Tafole sekhahla 3 nyamele le matšoao a mang le lipontšo bakuli NCP (%)

Project

Case palo Pele Phekolo

Case Phokotso mor'a kalafo

Sefubeng mahlomola (n g = 54)

13 (24.1)

11 (84.6)

Dyspnea (n g = 54)

8 (14.8)

8 (100.0)

Ipolaisa tlala (n g = 54)

10 (tsa 18.5)

4 (40.0)

Mongobo rales (n g = 54)

19 (35.2)

17 (89.5)

2,4.       Phekolo bokgoni Matsatsi a mararo ka mor'a kalafo, 23 ea 54 NCP bakuli ne e atlehang (46.9%); matsatsi a mahlano ka mora kalafo, 34 e ne e le e atlehang (69.4%); ka matsatsi a supileng ka mor'a kalafo, 40 e ne e le e atlehang (81.6%). Sheba Table 4 le Figure 3.

Tafole 4 e atlehang tekanyo ea NCP bakuli tloaelehile hore batho ba mofuta [mabokosana (%)]

Project

3d mora kalafo

5d mora kalafo

7d mora kalafo

E sebetsang hantle (n g = 54)

23 (46,9)

34 (69,4)

40 (81,6)

Lefeela (n g = 54)

26 (53,1)

15 (30.6)

9 (18.4)

 

2,5.       Safety and analysis mor'a and analysis, ho ne ho se na totobetse aggravation ka mali kemiso teko, sebete le liphio mosebetsi teko ka tsela ea Lianhuaqingwen Granule kopantswe le kalafo kemiso. Bapisoa le previos kalafo, bakuli bohle ba ka ntle ho le matšoao a pele la pampitšana matšoafo le pampitšana tshilong ya dijo ba ne ba sa hlahella matšoao a boemong bo sa thabiseng e ncha kapa a mpefatsang lipontšo, fana ka maikutlo a hore Lianhuaqingwen Granule sireletsehile kopo ea tleleniki.

3.        Buisanang

Ho latela lipatlisiso, coronaviruses fumanoa ke batho ba ajoang ho pholletsa le batho le liphoofolo tse anyesang tse ling, batho ba bang ba na le matšoao a bonolo ka mor'a hore a le tšoaetso ea coronavirus, empa batho ba bang ba na le matšoao a matla le esita death.During lilemong tse 20 tse fetileng, ba babeli ba tummeng β-coronaviruses di haholo a hlobaetsang le ho hema Syndrome kokoana-hloko ea (SARS-CoV) le Bochabela bo Hare ho hema Syndrome Coronavirus (MERS-CoV), le ditefello ho shoa ha tshwaetso tse 10% le 37% ho latellana. Leha ho le joalo, ho coronavirus fumanoa ke batho ba feela ntlha ea thula thaba ea leqhoa le. Ho ka etsahala hore ho feta le mafu zoonotic le coronaviruses haholo a tšoaetsanoang ba ne ba tla fumana nakong e tlang [6] . Seoa sena se ile a etsa hore ke SARS-CoV-2 [7] , e leng e le 'ngoe-Strand RNA hahang-Strand aparela β-coronavirus, ho ba le e phahameng boemo ba tatelano tšoana le potlakisang tsebetso ea lik'hemik'hale ea SARS mme MERS. Ho phaella moo, ho hlahloba e bontša protheine sebopeho hore tlama "pokothong" ea SARS-CoV-2, SARS mme MERS kokoana-hloko enzyme le lithethefatsi ke mekhoa e tloaetsoeng, kahoo, ho e a hakanya hore pejana-ba khahlanong le SARS mme MERS lithethefatsi li ka sebelisoa ka NCP kalafo [8] .

Haufinyane tjena, and analysis ea tleleniki ea 1.099 NCP bakuli ba tsoang liprofinseng 31 'me metse ea tlaleha hore palo ea feberu le khohlela bakuli sepetlele e ne e le 87,9% le 67,7% [3] ,' me e mong bakuli 138 le NCP ithuta Clinical fumanoa hore matšoao a ka sehloohong ea tleleniki kenyeletsa feberu (98.6%), asthenia (69.6%), khohlela (59.4%), palo yohle shoang ne 4.3% [4] , 'me tlaleho ea bakuli 12 hape e ile ea tlaleha hore le matšoao a ka sehloohong ke khohlela (46.3%), e ka holimo ho hema pampitšana tsubuhlellano (61.5%), myalgia (23.1%) le ho hlooho e opang (23.1%) [9] . "Hlahloba le Phekolo Program bakeng bukeng Coronavirus serame sa matšoafo (Nyeoe Fifth Edition) [5] o ile a ntša ke Komisi National Bophelo" e bolela hore lefu le matšoao a ka sehloohong ke feberu, asthenia, le ho khohlela. Ho fihlela ho hona joale, ho na le hase e atlehang antiviral lithethefatsi ho tsoara le NCIP, letšoao thehiloeng tšehetsang phekolo le ho kenella akaretsang hona joale o sebelisoang ke tleliniking. Ka hona, le kalafo ntlafatsa matšoao a litleleniki tsa, tse kang feberu, asthenia, le khohlela amanang le lefu lena, ho ba le e moholo ea tleleniki ea bohlokoa bakeng sa ho fokotsa ho tiea la lefu lena le ho fokotsa bolelele ba nako ba lefu lena.

The Fetileng Motheo le Clinical Liteko tsa Lianhuaqingwen komiki (Granules) o ile a bontša hore LH-C ka ho hlakile hore thibela metsoako e SARS-CoV viruse exsiting ka ka vitro setso ea lisele, 'me na le litla bohlokoa inhibitory ka H1N1, H3N2, H7N9 kokoana-hloko ntaramane joalo joalo [ 11-12] , 'me na ha ho na phapang le Oseltamivir phosphate tswa ho fokotsa nako ya acid e bongata ba kokwanahloko nucleic ea H1N1 bakuli ntaramane fetola ho mpe le bolelele ba le matšoao a bohle ntaramane,' me ka remitted feberu, lopollang khohlela, mesifa ache, asthenia le matšoao a tse ling [ 13,14] , hona, ya data ea tleleniki ea motsoako oa Lianhua Qingwen Granules bakeng sa kalafo ea bakuli ho tloaelehile hore batho NCP ho tloha ka la 1 January ho 30, 2020 li ne li akaretsa le li hlahlobisisa ka ntlafatso bokgoni ka feberu, asthenia, khohlela le matšoao a tse ling tse retrospectively. E ile a fumana hore ka tlas'a motheong oa kalafo kemiso, motsoako oa Lianhuaqingwen Granule bakeng sa matsatsi a 3, feberu ea nyamela sekhahla ke 47,5%; ka mor'a ho tšoara ka matsatsi a 5, feberu, asthenia le khohlela nyamele ditefello tse 62,5%, 59,5%, le ho 50,0%; ka mor'a ho tšoara ka matsatsi a 7, feberu, asthenia, le khohlela nyamele ditefello tse 80,0%, 75,7%, le ho 76,7% ho latellana. Ka karolelano ea nyamela nako ke matsatsi a 3,6, matsatsi a 4.1, 'me matsatsi a 5.3 go, e leng fana ka maikutlo a hore Lianhuaqingwen komiki haholo lopollang matšoao se ka sehloohong sa feberu, asthenia, le khohlela, le boetse o na le bohlokoa Ntlafatso phello Fokotsa sefubeng tightness, dyspnea, le rales mongobo ea matšoafo, ka tekanyo e atlehang ke 81,6%. Ho bontša hore lithethefatsi e na le e ntle ea tleleniki e le hantle ho ntlafatsa matšoao a tlelenike, fokotsa le ho tiea tsa lefu lena le, le ho fokotsa bolelele ba nako ba sepetlele lula. Ho sekaseka ho eketsehileng ya data litleleniki tsa, har'a bakuli na le boloetse ba NCP mofuta tloaelehileng, nyeoe tloaelehileng o ile a khethoa le akaretsa tjena e le hore a fane ka likhopolo tse ngata tsa tleleniki bakeng sa kalafo ya le lefu lena.

A e motšehali, ea lilemo li 48, letsoalloa la Hubei, ha ho na tse ling histori lefu. Ka January 11, 2020, matšoao a ka sehloohong e ne e le feberu, khohlela, sekhohlela, 'metso, nko runny,' mele ache, wheezing, bokhutšoanyane phefumoloho. Sepetlele, ka sefubeng itlhahloba, sefubeng filimi le CT tsa matšoafong a etsa tlhahiso ea tšoaetso ea matšoafo. Ka mor'a ho tšoara le Ganciclovir (intravenous ente, 0.5g, 1 nako / ka letsatsi a) le oseltamivir (molomo, 1 komiki, makhetlo a 2 / ka letsatsi a), feberu pheta. CT ea matšoafo ka January 17 o ile a bontša "omimvo-matšoafo tšoaetso, bongata ba kokwanahloko serame sa matšoafo". Ka January 18, o ile a ile a lumela ho ea sepetlele le "tshwaetso methapo", 'meleng ho hlahloba ka:' mele mocheso 39.3 ℃, lebelo leo pelo 112 otla / mets, respiration sekhahla 25 breaths / mets, khatello ea mali 130/70 limilimithara Hg (1 limilimithara Hg = 0,133 kPa), e khubelu 'metso, teteaneng melumo ea matšoafo, li ile tsa phasalla omeletseng le e rales mongobo. Mali kemiso tlhlahlobo: tšoeu mali seleng ea count ya 3,53 × 10 9/ L, neutrophil karo-karolelano 67,2%, lymphocyte karo-karolelano 28,4%. Mali skeletal tlhlahlobo: Alt: 35,3 U / L, AST: 42.6U / L, albumin 35.0g / L, lactate dehydrogenase 370 U / L, hydroxybutyrate dehydrogenase 275 U / L, NCP nucleic acid e teko o ile a bontša boikutlo bo botle.

(1)
Figure 4: sefubeng CT sephetho

 

Mora kenoa, o ile a fuoa levofloxacin (intravenous ente, 0,4 g,, 1 nako / ka letsatsi a), vithamine C (intravenous ente, 3g, 1 nako / ka letsatsi a), ambroxol (Intravenous ente, 30mg, makhetlo a 2 / ka letsatsi a), Yanhuning (intravenous ente, 0,4 g,, 1 nako / ka letsatsi a), methylprednisolone (intravenous ente, 40 mg,, 1 nako / ka letsatsi a). Ka January 21, sefubeng CT o ile a bontša "diso tšoaetsanoang ka matšoafong bobeli, bapisoa le khatelo-pele fetileng (2020.01.17), omimvo mesothelioma motenya". Fetola na mwango ya kalafo, lethal dose Moxifloxacin (intravenous ente, 0,4 g,, 1 nako / d), ganciclovir (Intravenous ente, 0.5 g,, 1 nako / d), lethal dose Lianhua Qingwen Granules (molomo, 1 mokotla, makhetlo a 3 / d), le mocheso oa 'mele fetoha tloaelehile letsatsi le hlahlamang. Ka January 28 le ka January 31, The NCP teko e ne e le mpe, 'me ka Feberuary 01, mokuli o ne a sa feberu, khohlela, sekhohlela, teteaneng ho hema melumo ea matšoafo ka bobeli, e ommeng tse seng kae' me rales le mongobo, 'me sefubeng CT o ile a bontša absorbination ke totobetse ho feta pele, joalokaha ho bontšitsoe Figure 4, mali kemiso le litlhahlobo Biochemistry mali ne ho tloaelehile, 'me NCPs ne mpe bakeng sa 2 linako tse latellanang, dumellana le litleleniki tsa pheko e tloaelehileng. Ba ile ba lokolloa sepetlele 'me lethal dose mabokose 2 ya Lianhua Qingwen granules lapeng (molomo, 1 mokotla, makhetlo a 3 / d). Mokuli o ikutloa e ntle ka mor'a o latele-up ho fihlela joale, o na na le feberu, ho khohlela, sekhohlela le matšoao a tse ling.

Ka tse boletsoeng ka holimo-Maemong a tloaelehileng, ho mocheso oa 'mele o ile a khutlela ho tloaelehile letsatsi le hlahlamang ka mor'a hore kopo hlakanywa tsa Lianhuaqingwen Granules,' me matšoao le lipontšo tse kang khohlela le mongobo rales ne haholo ba ntlafala, e neng e ha e le hantle e lumellana le sephetho sa retrospective ho and analysis ea tleleniki ea linyeoe tse 54, senola menyetla bath ya motsoako Chinese moriana "molao oa tsamaiso ka kakaretso le selotlolo shebiloeng kalafo", fana ka maikutlo a hore Lianhuaqingwen Granules e na le bohlokoa litleleniki tsa kopo ea ho phekola bakuli ba NCP. Ho phaella moo, e lokela ho ile a bolela hore ho ithuta hona ke retrospective litleleniki tsa ho ithuta bakeng sa NCP fumanoa bakuli ba mofuta tloaelehileng, boholo sampole e nyenyane, se nang le ho bapisa sena ya bohlokwa ba tsamaiso ea sehlopha taolo, ba bang ba bakuli o ile a hlōleha ho phetha sefubeng ho nka litšoantšo ho hlahloba ka ka nako ea , le hantle litlhoko tsa litleleniki tsa bohlokwa ba tsamaiso ho hlahlojoa ke sampole e khōloanyane, ka moso, ea lotho laoloa ithuta litleleniki tsa.

Kgohlano thahasella: bangodi All phatlalatsa hore ho na le ha e hanane le thahasello.

ngoe e re:

[1] National Control Mafu le Thibelo Bureau. Tsebiso ya Komiti ea Republic Batho ba China [eb / ol] Bophelo National. (2020-01-20) [2020-02-17]. Http: // www e. Nhc. Gov.cn/jkj/s7916/202001.44a3b8245e8049d2837a4f27529cd386.shtml.

[2] Bophelo Mokhatlo oa Lefatše. De 2019 bukeng Coronavirus seoa Melawana International Bophelo (2005) "Polelo ea Seboka sa Bobeli e sa Komiti ea Emergency [eb / ol]. (2020- 01-30) [2020-02-17]. Https://www.who.Int/zh/news-room/.

[3] Weijie G, Zhangyi N. Yu H.et a al. charateristics Clinival tsa de 2019 bukeng corpnavirus inection Chaena [J / ol] MedRxiv, Posted February, 09, 2020.http: //dx.doi.org/10.1101/2020.02.06.20020974.

[4] moo Dawei W, Bo H, Chang H et al. Litšobotsi Clinical ea 138 sepetlele Bakuli ba de 2019 bukeng Corpnavirus le tšoaetso ea serame sa matšoafo ka Wuhan, China [J / ol] .JAMA hatisitsoe online, la 7 February, 2020. https://jamanetwork.com/journals/jama/article-abstract/2761044.

[5] Kakaretso Office tsa Komisi Bophelo National le Office ea State Administration tsa Traditional Chinese Medicine. Tsebiso ka Khatiso le ho aba hlahloba le Phekolo Program bakeng bukeng Coronavirus serame sa matšoafo (Nyeoe Fifth Edition) [eb / ol]. (2020-02-05) [2020-02-17]. http://www.nhc.gov.cn/yzygj/s7653p.

[6] Chaolin H, Yeming W, Xingwang L et al. makgetheng Clinical ea bakuli ba tšoaelitsoeng ke de 2019 bukeng corpnavirus ka Wuhan, China [J]. Lancet: January 24, 2020: 1-9.

[7] Bophelo Mokhatlo oa Lefatše. Clinical taolo ya tshwaetso haholo a hlobaetsang le resporatory ha bukeng Coronavirus (nCoV) tshwaetso e belaela: nakwana Guidence [eb / ol]. (2020-02-03) [2020-02-17]. https: //www.who.int/zh/news-room/detail/30-01-2020-statement-on-the bobeli-mmeting-of-the-machaba-bophelo-regulations- (2015) -emergency-commottee -regarding-the-qhoma-ea-bukeng-corpnavirus- (de 2019-ncov), 2020-01-12 / 2020-02-03.

[8] Guangdi L Erik D C. phekolo dikgetho bakeng sa de 2019 bukeng Coronavirus (nCoV) [J / ol] Nature Reviews lithethefatsi sibolloa, 2020-02-10. https: // www e. Nature.com/articles/d41573-020-00016-0.

[9] De C Minggui L, Lai W et al. Epidemiologic le istics Clinical Solo la bukeng Coronavirus tšoaetso ea amanang le 13 Bakuli Out [J / ol] JAMA. E hatisitsoeng online, la 7 February, 2020. https: //jamanet-work.com/journals/jama/fullarticle/2761043.

[10] Zhu Shunya, Li Xiaoying, Wei Yunling et al. ho ithuta selelekela ka ho vitro le phello inhibitory tse tharo tsa moetlo Chinese ditaelo tse di beilweng moriana ka coronavirus SARS-amanang [J]. Journal of thekenolojing ya diphedi, 2003, 14 (5): 390-392.

[11] Mo Hongzhang, Ke Changwen, Zheng Jinping et al. Liteko ithuta Lianhua Qingwen capsules khahlanong ntaramane A kokoana-hloko ea ho vitro [ya j]. New lithethefatsi tsa Traditional Chinese Medicine le Clinical Pharmacology, 2007, 18 (1): 6-9.

[12] Ding YW, Zeng LJ, Li RF, etal. The lengolo la ngaka Chinese lianhuaqingwen komiki le fana ka mosebetsi-ba khahlanong le ntaramane throught le thibelo ea boikatiso bongata ba kokwanahloko le tshusumetso mosebetsi boitshireletso [J]. BMCComplement Altern z, ka 2017, 17 (1): 130.

[13] Zhongping D, Zhenhua J, Jian Z et al. Natural litlama moriana Lianhuaqingwen komiki-ba khahlanong le ntaramane A (H1N1) teko; arandomized, doubleblind, o positive laoloa litleleniki tsa teko [J] .Chinese Medical Journal, 2011,124 (18): 2925-2933.

[14] Liu Xinhuan, Zhang Yanxia, ​​Yang Jiqing et al. Ea lotho laoloa ithuta tlelenike tsa Lianhuaqingwen komiki ea ho phekola ba ntaramane A H1NI [J]. Journal of Mafu a Thata, 2010, 9 (1): 14-16.

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