Soj ntsuam Zoo Analysis rau 54 NCP plaub nrog kev kho mob ntawm Lianhuaqingwen Granules cheng Dezhong, LI Yi

(Lub Puren chawv tsev kho mob ntawm Wuhan University of Science thiab Technology, Wuhan 430081, Tuam Tshoj)

Abstract Hom phiaj : Yuav kom ntsuam xyuas tus soj ntsuam hauj lwm zoo ntawm Lianhua Qingwen Granules (LH-C) rau tshiab coronavirus mob ntsws (NCP) cov neeg mob. Txoj kev : Lub soj ntsuam cov ntaub ntawv ntawm 54 zoo tib yam NCP neeg mob tau retrospectively analyzed nyob rau Puren chawv tsev kho mob rau Wuhan University of Science thiab Technology. tau: Tom qab kev kho mob nrog LH-C rau peb hnub sib law liag. Tus nqi ntawm cov tsos mob disappearance nyob rau hauv kub taub hau, asthenia thiab hnoos yog 47,5%, 35,1%, thiab 20,0%, ntsig txog. Tsib hnub tom qab, tus nqi ntawm cov tsos mob disappearance nyob rau hauv kub taub hau, asthenia thiab hnoos ntau zog rau 62,5%, 59,5%, thiab 50,0%, ntsig txog. Los ntawm lub xya hnub, tus nqi ntawm cov tsos mob disappearance nyob rau hauv kub taub hau, asthenia thiab hnoos txog ntawm 80,0%, 75,7%, thiab 76,7%. Lub hnub ntawm cov tsos mob disappearance nyob rau hauv kub taub hau, asthenia, thiab hnoos yog 3.6 ± 2,14 hnub, 4.1 ± 2.58 hnub, thiab 5.3 ± 2,63 hnub. Raws li regards rau lwm cov tsos mob disappearance nyob rau hauv lub hauv siab stuffiness, lub dyspnea, thiab cov noo crackles yog 84,6%, 100%, thiab 89,5%; thiab tag nrho cov ua hauj lwm zoo yog mus txog 81,6%, tsis muaj cai phiv los ntawm lub xya hnub. Xaus : LH-C yuav ho pab soj ntsuam cov tsos mob rau hauv dog dig NCP cov neeg mob los ntawm inhibiting kub taub hau, asthenia, thiab couch, thiab kev txo lawv cov ntev. Tag nrho cov tau muab ua ntej soj ntsuam cov pov thawj rau LH-C nyob rau hauv lub NCP kev kho mob.

Keywords: Lianhuaqingwen; SARS-Cov-2; NCP; Soj ntsuam miv nyuas siv zug; Retrospective tsom xam; raug mob

Suav faib tooj: R254.3; R256.19; R512.99

Ntawv qhia txog tus kheej code: A doi: 10. 3969 / j. Issn. 1673-7202. 2020. 02. 006

Tsis ntev los no, tus tshiab coronavirus mob ntsws (tshiab coronavirus Mob Ntsws Txheem Dej, NCP) phaum mob tau kis tus kab mob thiab nws tau dej num raws li cov chav kawm ntawv B kis kab mob (kev tswj raws li ib tug Class Ib tug kab mob) [1] . Ntau tshaj 20 lub teb chaws thiab regions nyob rau hauv lub ntiaj teb no muaj qhia paub tseeb hais tias tus neeg mob, thiab nws yog ua ib tug ntiaj teb no pej xeem noj qab haus huv kev tshwm sim [2] . Lub ntsiab ntawm cov tsos mob NCP yog kub taub hau, asthenia thiab hnoos qhuav. Ib tug ob peb cov neeg mob muaj cov tsos mob xws li qhov ntswg txhaws, los ntswg qhov ntswg, mob caj pas thiab raws plab. Nws yog qhia hais tias 15,7% ntawm NCP cov neeg mob mus pw hauv tsev kho mob, thiab cov kev soj ntsuam lub neej no tus nqi yog hais txog 1.4% [3] . Tej kev tshawb fawb kuj pom tau hais tias 26% ntawm cov neeg mob xav tau kev kho mob nyob rau hauv lub intensive kev saib xyuas tsev, thiab lub neej no tus nqi ntawm lub paub tseeb hais tias cov neeg mob yog 4.3% [4] , thiab ncua cov kev kho mob, cov kho nyhuv yog tsis tshua muaj teeb meem loj. Txawm li cas los, mus txog rau tam sim no, yog tsis muaj zoo antiviral tshuaj rau NCP, tab sis cov tsos mob raws li therapiesare mas siv. Peb siv Lianhuaqingwen Cov tshuab granule ua ke nrog niaj hnub kho mob los kho tus mob thiab tau txais kev tshwm sim zoo. Yog li ntawd, peb nyob ntawm no qhia txog ib retrospective tsom xam rau cov kev soj ntsuam cov ntaub ntawv ntawm lub 54 NCP cov neeg mob nyob rau hauv peb lub tsev kho mob, nyob rau hauv thiaj li yuav txhim kho cov kev kho mob qib ntawm tus kab mob.

  1. 1.        Cov ntaub ntawv thiab cov hau kev

1.1.       General cov ntaub ntawv tshawb fawb lub hom phaj yog cov 54 tus neeg mob tshiab coronavirus mob ntsws uas raug kho nrog Lianhuaqingwen Granules ua ke nrog cov pa kho mob (raws li cov kev soj ntsuam ntawm tus kab mob, muab noj haus them nyiaj yug, antiviral kev kho mob thiab antibacterial kev kho mob) los ntawm Lub ib hlis ntuj 1-31, 2020 nyob rau hauv Puren tsev kho mob affiliated rau Wuhan University of Science thiab Technology. Qhov nruab nrab muaj hnub nyoog ntawm cov neeg mob yog 60,1 ± 16,98 xyoo, muaj xws li 29 cov txiv neej (53.7%) thiab 25 tus poj niam (46.3%); qhov nruab nrab lub cev kub yog (37.93 ± 0.93) ℃, theem nrab lub cev kub yog 38,05 ℃, thiab lub siab tshaj plaws lub cev kub ua ntej tus mob yog (38.54) ± 0.60) ℃; nruab nrab lub plawv dhia yog 87,9 ± 11,80 yeej / min, theem nrab lub plawv dhia tau 85,5 yeej / min, lub siab tshaj plaws tus nqi yog 112 beats / min; qhov nruab nrab ua pa yog 21,1 ± 3,78 pa / min, theem nrab tus nqi yog 20,0 pa / min, lub siab tshaj plaws tus nqi yog 30,0 pa / min; cov neeg uas muaj keeb kwm ntawm tawg yog 21 tus neeg mob (38.9%), thiab cov neeg uas muaj keeb kwm ntawm coronary mob plawv yog 7 tus neeg mob (13%). Muaj 10 tus neeg mob ntshav qab zib mellitus (18.5%), 10 tus neeg mob ntawm cerebral infarction (18.5%). Rau laboratory xeem: 31 tus neeg mob (64.6%) ntawm cov leucocytes nyob rau hauv lub cev ntau, 9 tus neeg mob (18.8%) txo tshaj lub qub nqi, 8 mob (16.7%) ntau dua li cov qub tus nqi; 25 tus neeg mob (52.1%) ntawm cov qe nyob rau hauv lub cev ntau, 23 tus neeg mob (47.9%) tau siab tshaj lub qub nqi, 14 tus neeg mob (29.2%) nyob rau hauv lub cev ntau, 34 tus neeg mob (70.8%) yog qis dua lub qub nqi ; tag nrho cov neeg muaj C-reactive protein ntau ntau dua li ib txwm. Tag nrho cov neeg mob raug kho nrog Lianhuaqingwen Granules rau ib tug nruab nrab ntawm 8.0 ± 4.10 hnub, nrog ib tug nruab nrab ntawm 7.0 hnub, ib tug tsawg kawg nkaus ntawm 1.0 hnub thiab ib tug tshaj plaws ntawm 16.0 hnub.

Rooj 1 General Information ntawm NCP neeg mob

Yam

mob

(Count)

Tshwm

Project

mob

(Count)

Tshwm

Muaj hnub nyoog

54

60,10 ± 16,98

Mesenchymal hlwb (%)

Txiv neej (%)

29

53,7

Qhov

25

52,1

Lub cev kub

54

37,93 ± 0,93

Tsawg

0

0.0

Lub plawv dhia (beats / min)

54

87,90 ± 11,80

High

23

47,9

Ua pa nqi (ua pa / min)

54

21,10 ± 3,78

Lub lymphocyte (%)

Kev kho mob keeb kwm

Qhov

14

29,2

Ntshav siab

21

38,9

Tsawg

34

70,8

Mob plawv

7

13

High

0

0.0

Mob ntshav qab zib mellitus

10

18.5

C-reactive protein (%)

cerebral infarction

10

18.5

Qhov

0

0.0

Dawb ntshav (%)

Tsawg

0

0.0

Qhov

31

64,6

High

44

100,0

Tsawg

9

18,8

Hnub nrog kev kho mob ntawm Lianhuaqingwen Granules

54

8.0 ± 4.10

High

8

16,7

1.2.       Diagnostic kev neeg mob tau raug tshuaj mob li NCP zoo thaum lawv tau ntsib cov diagnostic luj rau tshiab coronavirus kab mob (trial version fifth) [5] , thiab tsom zoo tau nrog cov nucleic acid xeem ua rau hnoos qeev, caj pas kua ntswg thiab txo pa ib ntsuj av tau kua.

1.3.       Inclusion kev Lub [5] nyob rau hauv-cov neeg mob uas muaj 18 xyoo thiab raws li cov NCP diagnostic luj.

1.4.       Cais kev 1) loj thiab tseem ceeb heev NCP cov neeg mob; 2) muaj lwm yam mob ua pa kab mob, ua pa kab mob kab mob xws li suppurative tonsillitis, mob tracheobronchial bronchitis, sinusitis, otitis xov xwm thiab lwm cov kab mob ua pa uas cuam tshuam rau kev soj ntsuam mus sib hais kev ntsuam xyuas; 3) loj thawj immunodeficiency, Acquired immunodeficiency syndrome, congenital pa malformation congenital kab mob plawv, koj muaj teebmeem kev dysplasia thiab lwm yam kab mob.

1.5.       Kev kho mobLianhuaqingwen Cov tshuab granule (Beijing Yiling., Gyzz20100040) twb hais noj, 1 lub hnab / lub sij hawm, 3times / d; Lub ntsiab kho tshuaj twb tso dej txhaj tshuaj ntawm tib neeg immunoglobulin (Guizhou Taibang lom khoom Co., Ltd., GJZ s20023034) 2.5g, ib zaug ib hnub twg; ganciclovir txhaj tshuaj (Hubei Keyi Kws Co., Ltd., GJZ h10980188) 0.5g, ib zaug ib hnub twg; Levofloxacin Hydrochloride Txhaj (Hu Hu Nanwuzhoutong Kws Co., Ltd., gjzz h20083916) 0.4g, ib zaug ib hnub twg; Methylprednisolone Sodium Succinate cov kev txhaj tshuaj (Liaoning hisico Kws Co., Ltd., gjzz h20133234) 40mg, ib zaug ib hnub twg.

1.6.       Soj index Lub soj ntsuam cov ntaub ntawv ntawm 54 NCP cov neeg mob tau analyzed, nrog rau cov disappearance tus nqi ntawm lub ntsiab tsos mob (ua npaws, asthenia, hnoos) tom qab 3, 5, 7 hnub, lub disappearance hnub ntawm kev kub taub hau thiab lwm yam kev mob thiab tej yam tshwm sim.

1.7.       Kev Cai rau miv nyuas siv zug ntsuam xyuas lub ntsiab tsos mob "tsis muaj" yog muab raws li 0 point, thiab "yog" li 1 point. (ua ntej kev kho mob - tom qab kev kho mob) / ua ntej kev kho mob yog cov tsos mob tau yuav txo tau tus nqi, thaum tau yog ntau tshaj li 30%, nws yog ntshai li txoj kev kho, thaum tau yog tsawg tshaj li 30%, nws yog ntshai li tawg paj txi txiv kev kho mob, thaum tau yog ntau tshaj li 30%, nws yog ntshai li txoj kev kho / tag nrho cov xov tooj ntawm tus neeg mob tom qab kev kho mob raws li txoj kev kho efficiency, cov kev kho mob ua hauj lwm zoo ntawm txhua tus neeg mob tom qab 3, 5 thiab 7 hnub ntawm kev kho mob yog analyzed.

1.8.       Statistical txoj kev tshawb no siv SAS 9.4 software rau descriptive tsom xam, cov suav cov ntaub ntawv yog piav los ntawm tus xov tooj ntawm tus neeg mob thiab cov muaj pes tsawg leeg ratio, cov kev ntsuas cov ntaub ntawv yog piav los ntawm tus phem ± txheem sib txawv los yog nruab nrab, thiab lub hauv paus cov ntaub ntawv thiab cov miv nyuas siv zug indexes ntawm txhua mus xyuas point yog piav thiab analyzed.

  1. 2.        Tshwm

2.1.       Disappearance tus nqi ntawm lub ntsiab tsos mob (ua npaws, asthenia, hnoos) 1) Ua ntej cov kev kho mob, muaj 40 tus neeg mob ntawm kub ib ce (74.1%), 37 tus neeg mob ntawm asthenia (68.5%), 30 tus neeg mob hnoos (55.6%); 2) Tom qab 3 hnub ntawm kev kho mob, muaj 19 tus neeg mob ntawm kub ib ce (47.5%), 13 tus neeg mob ntawm asthenia (35.1%), 6 tus neeg mob hnoos (20.0%); 3) Tom qab 5 hnub ntawm kev kho mob, ua npaws zoo nyob rau hauv 25 tus neeg mob (62.5%), asthenia nyob rau hauv 22 tus neeg mob (59.5%), hnoos nyob rau hauv 15 tus neeg mob (50.0%); 4) Tom qab 7 hnub ntawm kev kho mob, ua npaws zoo nyob rau hauv 32 tus neeg mob (80.0%), asthenia nyob rau hauv 28 tus neeg mob (75.0%) Cov hnoos cov tsos mob zoo nyob rau hauv 23 tus neeg mob (76.7%). Saib cov lus 2 thiab Daim duab 1.

 

 

Rooj 2 Disappearance tus nqi ntawm lub ntsiab tsos mob nyob rau hauv NCP cov neeg mob (%)

Project

Case Number Ua ntej kev kho mob

Txo tus neeg mob tom qab 3d kev kho mob

Txo tus neeg mob tom qab 5D kev kho mob

Txo tus neeg mob tom qab 7d kev kho mob

Ua npaws (n = 54)

40 (74,1)

19 (47.5)

25 (62.5)

32 (80)

Asthenia (n = 54)

37 (68,5)

13 (35.1)

22 (59.5)

28 (75.7)

Hnoos (n = 54)

30 (55.6)

6 (20.0)

15 (50.0)

23 (76,7)

2.2.      
Main symptoms (fever, asthenia, cough) disappeared time 1) The average disappearance time of fever symptoms was (3.6 ± 2.14) days, median disappearance time was 3.0 days, with the shortest time as 1.0 days and the longest time as 8.0 days; 2) the average disappearance time of asthenia symptoms were (4.1 ± 2.58) days, median disappearance time were 4.0 days, the shortest 1.0 days, the longest 12.0 days; 3) the average disappearance of cough symptoms days (5.3 ± 2.63) d, median disappearing days (5.0 d), minimum disappearing days (1.0 d), maximum disappearing days (12.0 d).

71
Daim duab 1 Disappearance tus nqi ntawm lub ntsiab tsos mob nyob rau hauv NCP cov neeg mob

81

Daim duab 2 Disappearance tus nqi ntawm lwm yam kev mob thiab tej yam tshwm sim nyob rau hauv NCP cov neeg mob

85

Daim duab 3 Kev Kho Mob efficiency ntawm NCP cov neeg mob

2.3.       Disappearance tus nqi ntawm lwm yam kev mob thiab tej yam tshwm sim 1) Ua ntej kev kho mob: 13 tus neeg mob (24.1%) muaj siab nyuaj siab, 8 mob (14.8%) muaj dyspnea, 10 tus neeg mob (18.5%) muaj anorexia, thiab 19 tus neeg mob (35.2%) muaj noo rales ; 2) 7 hnub tom qab kev kho mob: 2 tus neeg mob muaj siab nyuaj siab, nrog 11 tus neeg mob (84.6%) zoo, 0 tus neeg mob muaj dyspnea, nrog 8 tus neeg mob zoo. Muaj 6 tus neeg mob ntawm anorexia, nrog 4 tus neeg mob odisappeared (40.0%), 2 tus neeg mob ntawm noo rales, nrog 17 tus neeg mob zoo (89.5%). Saib cov lus 3 thiab daim duab 2.

Rooj 3 Disappearance tus nqi ntawm lwm yam kev mob thiab tej yam tshwm sim nyob rau hauv NCP cov neeg mob (%)

Project

Case tooj Ua ntej kev kho mob

Case Yuav txo tau kev kho mob Tom qab

Siab nyuaj siab (n = 54)

13 (24.1)

11 (84.6)

Dyspnea (n = 54)

8 (14.8)

8 (100.0)

Anorexia (n = 54)

10 (18.5)

4 (40.0)

Noo rales (n = 54)

19 (35.2)

17 (89,5)

2.4.       Kev kho mob efficiency Peb hnub tom qab kev kho mob, 23 ntawm 54 NCP cov neeg mob twb zoo (46.9%); tsib hnub tom qab kev kho mob, 34 twb zoo (69.4%); xya hnub tom qab kev kho mob, 40 twb zoo (81.6%). Saib cov lus 4 thiab Daim duab 3.

Rooj 4 zoo npaum li cas ntawm NCP ntau hom neeg mob [mob (%)]

Project

3d tom qab kev kho mob

5D tom qab kev kho mob

7d tom qab kev kho mob

Siv tau (n = 54)

23 (46,9)

34 (69,4)

40 (81,6)

Futile (n = 54)

26 (53.1)

15 (30.6)

9 (18.4)

 

2.5.       Kev Nyab Xeeb tsom xam Tom qab tsom xam, muaj tsis muaj cuab aggravation nyob rau hauv cov ntshav niaj hnub xeem, lub siab thiab lub raum muaj nuj nqi kuaj nyob rau hauv lub chav kawm ntawm Lianhuaqingwen Cov tshuab granule ua ke nrog niaj hnub kho mob. Piv nrog rau previos kev kho mob, tag nrho cov neeg tsuas yog cov thawj tsos mob ntawm kev ua pa ib ntsuj av tau thiab digestive ib ntsuj av tau tsis tshwm tshiab tsis xis nyob tsos mob los yog thab plaub tej yam tshwm sim, tawm tswv yim hais tias Lianhuaqingwen Cov tshuab granule muaj kev ruaj ntseg nyob rau hauv cov kev soj ntsuam daim ntawv thov.

3.        Sib tham txog

Raws li kev tshawb fawb, coronaviruses pom los ntawm cov tib neeg cov lug faib thoob plaws hauv tib neeg thiab lwm yam tsiaj, ib txhia neeg muaj tshwm sim me me tom qab kis tau kab mob coronavirus, tab sis ib txhia neeg muaj mob loj thiab txawm death.During yav dhau los 20 xyoo, ob nrov β-coronaviruses yog loj mob ua pa Syndrome Virus (SARS-cov) thiab Middle East pa Syndrome coronavirus (MERS-cov), tus kab mob no lub neej no nqi yog 10% thiab 37% feem. Txawm li cas los, lub coronavirus pom los ntawm cov tib neeg tsuas yog qhov ntxeev ntawm lub iceberg. Nws yog yuav hais tias ntau zoonotic cov kab mob thiab mas kab coronaviruses yuav muaj nyob rau hauv lub neej yav tom ntej [6] . Qhov no phaum mob yog tshwm sim los SARS-Cov-2 [7] , uas yog ib tug hluas-strand RNA zoo-strand enveloped β-coronavirus, muaj ib theem siab ib theem zuj zus zoo sib thooj nrog lub enzymes ntawm SARS thiab MERS. Nyob rau hauv tas li ntawd, tus tsom xam ntawm cov protein qhia tau hais tias cov losis tswvyim dabtsi "lub hnab tshos" ntawm SARS-Cov-2, SARS thiab MERS tus kab mob no enzymes nrog tshuaj yog conservative, li ntawd nws yog speculated tias yav dhau los anti-SARS thiab MERS tshuaj yuav tsum tau siv nyob rau hauv NCP kev kho mob [8] .

Tsis ntev los no, ib tug soj ntsuam tsom xam ntawm 1.099 NCP cov neeg mob los ntawm 31 lub xeev thiab lub zos tshaj tawm hais tias cov kev faib ua feem ntawm ua npaws thiab hnoos nyob rau hauv pw tsev kho mob cov neeg mob yog 87,9% thiab 67,7% [3] , thiab lwm 138 cov neeg mob uas NCP soj ntsuam txoj kev tshawb nrhiav hais tias lub ntsiab soj ntsuam cov tsos mob muaj xws li kub ib ce (dua 98.6%), asthenia (69.6%), hnoos (59.4%), tag nrho lub neej no tus nqi yog 4.3% [4] , thiab ib daim ntawv qhia ntawm 12 cov neeg mob kuj qhia tias tseem ceeb tsos mob hnoos (46.3%), upper pa ib ntsuj av tau congestion (61.5%), myalgia (23.1%) thiab mob taub hau (23.1%) [9] . "Mob thiab Kev Kho Mob Program rau tshiab coronavirus Mob Ntsws Txheem Dej (Trial Fifth tsab) [5] muab los ntawm National Health Commission" hais tias tus kab mob no tseem ceeb tsos mob kub taub hau, asthenia, thiab hnoos. Mus txog rau tam sim no, muaj yog tsis zoo tshuaj antiviral rau treat nrog NCIP, cov tsos mob raws li txhawb kev kho mob thiab kev pab tam sim no siv los ntawm lub tsev kho mob. Yog li ntawd, kev kho mob kev txhim kho cov kev soj ntsuam mob, xws li kub taub hau, asthenia, thiab hnoos txog rau tus kab mob, muaj ib tug yawm soj ntsuam tseem ceeb rau alleviating lub heev ntawm tus kab mob thiab kom txhob muaj lub caij ntawm tus kab mob.

Lub Previous Hauv paus thiab soj ntsuam hlw kom qis ntawm Lianhuaqingwen Tshuaj Ntsiav (Granules) qhia hais tias LH-C yuav obviously inhibit qhov kev SARS-Cov viruse exsiting nyob rau hauv nyob rau hauv vitro kab lis kev cai ntawm lub hlwb, thiab muaj teeb meem loj inhibitory los ntawm cov khaub thuas H1N1, H3N2, H7N9 kab mob khaub thuas thiab thiaj li nyob [ 11-12] , thiab muaj tsis muaj qhov txawv nrog Oseltamivir Phosphate los ntawm kev txo qhov ntev ntawm tus kab mob nucleic acid ntawm H1N1 influenza cov neeg mob hloov kom zoo thiab ntev ntawm tag nrho cov kab mob khaub thuas mob, thiab muaj peev xwm remitted kub taub hau, relieves hnoos, mob mob, asthenia thiab lwm yam kev mob [ 13,14] , Yog li ntawd, tus soj ntsuam cov ntaub ntawv ntawm lub ua ke ntawm Lianhua Qingwen Granules rau cov kev kho mob ntawm ntau NCP cov neeg mob los ntawm lub ib hlis ntuj 1 mus rau 30, 2020 tau sau ua ke thiab analyzed nyob rau hauv kev txhim kho lub peev xwm rau kub taub hau, asthenia, hnoos thiab lwm yam kev mob retrospectively. Nws pom hais tias nyob rau hauv lub hauv paus ntawm niaj hnub kho mob, thaum lawv tseem Lianhuaqingwen Cov tshuab granule rau 3 hnub, tus npaws zoo npaum li cas yog 47,5%; tom qab kho rau 5 hnub, kub taub hau, asthenia thiab hnoos disappearance nqi yog 62,5%, 59,5%, thiab 50,0%; tom qab kho rau 7 hnub, lub kub taub hau, asthenia, thiab hnoos disappearance nqi yog 80,0%, 75,7%, thiab 76,7% feem. Qhov nruab nrab disappearing lub sij hawm yog 3.6 hnub, 4.1 hnub, thiab 5.3 hnub, uas yuav qhia tau tias Lianhuaqingwen Tshuaj Ntsiav ho relieves lub ntsiab ntawm cov tsos mob kub taub hau, asthenia, thiab hnoos, thiab tseem muaj ib tug tseem ceeb kev txhim kho nyhuv on relieving siab ceev ceev, dyspnea, thiab noo noo rales mob, lub zoo npaum li cas yog 81,6%. Nws qhia tau hais tias cov tshuaj muaj ib tug zoo soj ntsuam cov nyhuv rau kev txhim kho cov kev soj ntsuam mob, alleviating lub heev ntawm tus kab mob no, thiab txo lub caij ntawm lub tsev kho mob nyob. Yuav kom ntxiv tsom xam soj ntsuam cov ntaub ntawv, ntawm qhov cov neeg mob mob NCP ntau hom, ib tug raug cov ntaub ntawv raug xaiv thiab sau ua ke raws li nram no nyob rau hauv thiaj li muab soj ntsuam lub tswv yim rau cov kev kho mob ntawm tus kab mob.

Ib tug poj niam, 48 xyoo, haiv neeg ntawm Hubei, tsis muaj lwm yam kab mob yav dhau los. Nyob rau lub ib hlis ntuj 11, 2020, lub ntsiab tsos mob twb ua npaws, hnoos, hnoos qeev, mob qa, los ntswg qhov ntswg, lub cev mob, hawb pob, txog siav. Thaum lub tsev kho mob, ib tug siab kev xeem, lub hauv siab zaj duab xis thiab ib tug CT ntawm lub ntsws pom tias tus kab mob ntsws. Tom qab kho nrog Ganciclovir (tso dej txhaj tshuaj, 0.5g, 1 lub sij hawm / hnub) thiab oseltamivir (qhov ncauj, 1 capsule, 2 lub sij hawm / hnub), ua npaws rov qab. CT ntsws rau Lub ib hlis ntuj 17 tsom "ob sab sib dho-tus kab mob ntsws, mob ntsws Viral". Nyob rau lub ib hlis ntuj 18, nws tau mus nyob hauv lub tsev kho mob nrog "pulmonary kab mob", lub cev xeem: lub cev kub 39.3 ℃, lub plawv dhia 112 beats / min, kev ua pa nqi 25 pa / min, ntshav siab 130/70 hli Hg (1 hli Hg = 0,133 kPa), liab caj pas, tuab ntsws suab, tawg qhuav thiab noo noo rales. Ntshav niaj hnub xeem: cov ntshav dawb cell count 3,53 × 10 9/ L, Neutrophil piv 67,2%, lymphocyte piv 28,4%. Ntshav biochemical kev xeem: ALT: 35,3 U / L, AST: 42.6U / L, albumin 35.0g / L, lactate dehydrogenase 370 U / L, hydroxybutyrate dehydrogenase 275 U / L, NCP nucleic acid xeem tsom zoo.

(1)
Daim duab 4: siab CT tau

 

Tom qab nkag, nws tau muab levofloxacin (tso dej txhaj tshuaj, 0.4 g, 1 lub sij hawm / hnub), vitamin C (tso dej txhaj tshuaj, 3g, 1 lub sij hawm / hnub), ambroxol (tso dej txhaj tshuaj, 30mg, 2 lub sij hawm / hnub), Yanhuning (tso dej txhaj tshuaj, 0.4 g, 1 lub sij hawm / hnub), methylprednisolone (tso dej txhaj tshuaj, 40 mg, 1 lub sij hawm / hnub). Nyob rau lub ib hlis ntuj 21, hauv siab CT tsom "kab txhab nyob rau hauv ob qho tib si ntsws, muab piv rau yav dhau los kev kawm (2020.01.17), ob sab sib dho pleural thicker". Kho kev kho mob txoj kev npaj, koob tshuaj Moxifloxacin (tso dej txhaj tshuaj, 0.4 g, 1 lub sij hawm / d), ganciclovir (tso dej txhaj tshuaj, 0.5 g, 1 lub sij hawm / d), koob tshuaj Lianhua Qingwen Granules (qhov ncauj, 1 lub hnab, 3 lub sij hawm / d), lub lub cev kub tig mus rau hauv ib txwm hnub tom ntej. Nyob rau lub ib hlis ntuj 28 thiab nyob rau lub ib hlis ntuj 31, Lub NCP xeem yog tsis zoo, thiab nyob rau Feberuary 01, tus neeg mob twb tsis muaj kub taub hau, hnoos, hnoos qeev, tuab ua tsis taus pa suab ntawm ob lub ntsws, ib tug ob peb qhuav thiab noo noo rales, thiab lub hauv siab CT tsom absorbination yog cuab kev ntau dua li ua ntej, raws li qhia nyob rau hauv Daim duab 4, cov ntshav sij thiab cov ntshav biochemistry xeem twb ib txwm, thiab cov NCPs twb tsis zoo rau 2 sib law liag lub sij hawm, ua raws li cov kev soj ntsuam kev kho txheem. Lawv raug rho tawm los ntawm lub tsev kho mob thiab txhaj koob tshuaj 2 thawv ntawm Lianhua Qingwen granules nyob rau hauv tsev (qhov ncauj, 1 lub hnab, 3 lub sij hawm / d). Tus neeg mob pom tau tias zoo tom qab rov qab-up kom deb li deb, muaj tsis muaj kub taub hau, hnoos, hnoos qeev thiab lwm yam kev mob.

Nyob rau hauv lub saum toj no-hais raug tus neeg mob, lub cev kub rov qab mus rau li qub ib hnub tom ntej tom qab lub neej coj daim ntawv thov ntawm Lianhuaqingwen Granules, thiab cov tsos mob thiab cov tsos mob xws li hnoos thiab noo noo rales tau ho khees me ntsis, uas yog cia li muaj raws li qhov kev tshwm sim ntawm lub retrospective soj ntsuam tsom xam ntawm 54 tus neeg mob, pom tus yam ntxwv zoo ntawm tus compound Suav tshuaj "zuag qhia tag nrho kev cai thiab multi-lub hom phiaj kev kho mob", tawm tswv yim hais tias Lianhuaqingwen Granules muaj ib qho tseem ceeb soj ntsuam daim ntawv thov nyob rau hauv cov kev kho mob ntawm NCP cov neeg mob. Nyob rau hauv tas li ntawd, nws yuav tsum tau qhia hais tias txoj kev tshawb no yog ib tug retrospective kev soj ntsuam tshawb rau NCP thiaj paub hais tias hom neeg mob, cov qauv loj yog me me, tsis muaj kev sib piv ntawm cov miv nyuas siv zug ntawm lub pab pawg neeg tswj, ib co neeg mob ua tsis tau tejyam ua siab imaging xeem nyob rau hauv lub sij hawm , thiab lub caij nyoog soj ntsuam miv nyuas siv zug xav tau kev pab yuav tsum tau soj ntsuam los ntawm loj qauv, tus neeg tham lwm, randomized tswj kev soj ntsuam tshawb.

Tej teeb meem ntawm kev txaus siab: Tag nrho cov sau phau ntawv tshaj tawm hais tias muaj yog tsis muaj teeb meem ntawm kev txaus siab.

reference:

[1] Lub teb chaws Disease Control and Prevention Bureau. Tshaj tawm ntawm lub teb chaws Health Committee ntawm cov neeg 's koom pheej ntawm Tuam Tshoj [EB / OL]. (2020-01-20) [2020-02-17]. Http: // www. Nhc. Gov.cn/jkj/s7916/202001.44a3b8245e8049d2837a4f27529cd386.shtml.

[2] World Health Organization. 2019 tshiab coronavirus phaum mob International Health Regulations (2005) "Statement ntawm lub Ob txhais rooj sib tham ntawm lub Emergency Committee [EB / OL]. (2020- 01-30) [2020-02-17]. Https://www.who.Int/zh/news-room/.

[3] Weijie G, Zhangyi N. Yu H.et al. Clinival charateristics ntawm 2019 tshiab corpnavirus inection nyob rau hauv Tuam Tshoj [J / OL] MedRxiv, Muab tso rau lub ob hlis ntuj, 09, 2020.http: //dx.doi.org/10.1101/2020.02.06.20020974.

[4] Dawei W, Bo H, Chang H, li al. Soj ntsuam yam ntxwv ntawm 138 pw tsev kho mob cov neeg uas 2019 Tshiab Corpnavirus mob Mob Ntsws Txheem Dej hauv Wuhan, Tuam Tshoj [J / OL] .JAMA Luam tawm hauv internet Lub ob hlis ntuj 7, 2020. https://jamanetwork.com/journals/jama/article-abstract/2761044.

[5] General Office ntawm lub National Health Commission thiab cov chaw ua hauj lwm ntawm lub State Administration tsoos suav tshuaj. Daim ntawv ceeb toom rau Printing thiab Distributing kuaj thiab kho mob Program rau tshiab coronavirus Mob Ntsws Txheem Dej (Trial Fifth tsab) [EB / OL]. (2020-02-05) [2020-02-17]. http://www.nhc.gov.cn/yzygj/s7653p.

[6] Chaolin H, Yeming W, Xingwang L, et al. Soj ntsuam nta ntawm cov neeg mob tus kab mob 2019 tshiab corpnavirus nyob rau hauv Wuhan, Tuam Tshoj [J]. Lancet: Lub ib hlis ntuj 24, 2020: 1-9.

[7] World Health Organization. Soj ntsuam kev tswj kev mob mob resporatory kab mob thaum tshiab coronavirus (nCoV) kab mob yog xav tias: Interim Guidence [EB / OL]. (2020-02-03) [2020-02-17]. https: //www.who.int/zh/news-room/detail/30-01-2020-statement-on-the thib ob-mmeting-of-the-thoob ntiaj teb-noj qab haus huv-regulations- (2015) -emergency-commottee -regarding-tus-mas-of-tshiab-corpnavirus- (2019-ncov), 2020-01-12 / 2020-02-03.

[8] Guangdi L Erik D C. Therapeutic kev xaiv rau tus 2019 tshiab coronavirus (nCoV) [J / OL] Xwm Xyuas Tshuaj Discovery, 2020-02-10. https: // www. Nature.com/articles/d41573-020-00016-0.

[9] De C Minggui L, Lai W, li al. Epidemiologic thiab soj ntsuam Character istics ntawm tshiab coronavirus kab mob uas muaj 13 Cov neeg mob tawm [J / OL] JAMA. Luam tawm hauv internet Lub ob hlis ntuj 7, 2020. https: //jamanet-work.com/journals/jama/fullarticle/2761043.

[10] Zhu Shunya, Li Xiaoying, Wei Yunling, li al. Yam ua ntej txoj kev tshawb rau cov nyob rau hauv vitro inhibitory nyhuv ntawm peb tsoos suav tshuaj tshuaj rau SARS-txuam coronavirus [J]. Phau ntawv Journal ntawm Biotechnology, 2003, 14 (5): 390-392.

[11] Mo Hongzhang, Ke Changwen, Zheng Jinping, li al. Seb txoj kev tshawb no ntawm Lianhua Qingwen Tsiav tshuaj tiv thaiv mob ua npaws A tus kab mob no nyob rau hauv vitro [j]. Tshiab Drug tsoos suav tshuaj thiab soj ntsuam Pharmacology, 2007, 18 (1): 6-9.

[12] Ding YW, Zeng lj, Li RF, etal. Suav tshuaj lianhuaqingwen capsule niamntiav anti-kab mob khaub thuas ua si throught lub inhibition ntawm tus kab mob hais tawm thiab raug nyiaj tiv thaiv kab mob muaj nuj nqi [J]. BMCComplement Altern Med, 2017, 17 (1): 130.

[13] Zhongping D, Zhenhua J, Jian Z, li al. Ntuj herbal tshuaj Lianhuaqingwen capsule anti-mob ua npaws A (H1N1) mus sib hais; arandomized, doubleblind, zoo tshuaj soj ntsuam mus sib hais [J] .Chinese Medical Journal, 2011,124 (18): 2925-2933.

[14] Liu Xinhuan, Zhang Yanxia, ​​Yang Jiqing, li al. Xaiv tswj kev soj ntsuam tshawb ntawm Lianhuaqingwen Tshuaj Ntsiav nyob rau hauv cov kev kho mob ntawm kev mob ua npaws A H1NI [J]. Phau ntawv Journal ntawm Nyuaj kab mob, 2010, 9 (1): 14-16.

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